In-vitro release of vancomycin and netilmicin from bone cement

Leblebicioğlu, Hakan; Sanic, Ahmet; Günaydın, Murat; Şencan, İrfan; Dabak, Nevzat; Nas, Yunus

doi:10.1111/j.1469-0691.1996.tb00559.x

Cited by 5 publications

(2 citation statements)

References 6 publications

(5 reference statements)

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“…As nosocomial infections due to these organisms, notably multiply‐resistant E. faecium , increase, we can expect to encounter more enterococcal joint infections. The prevention of such infections requires a reconsideration of antibiotics for prophylaxis and in cement, as highlighted in recent correspondence [4], together with aggressive management of predisposing perioperative factors.…”

Section: Casementioning

confidence: 99%

Enterococcal joint prosthesis infection

Chadwick

Davis

Clayson

et al. 1997

Clinical Microbiology and Infection

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Section: Casementioning

confidence: 99%

Enterococcal joint prosthesis infection

Chadwick

Davis

Clayson

et al. 1997

Clinical Microbiology and Infection

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“…Thus the rate of complications is also increasing. Infection remains a serious complication [1], with current rates of infection in the primary prosthesis reported as 1.5% -2.5%, and 3.2% -5.6% after revision arthroplasty [2,3]. Nowadays, acute phase reactants such as body temperature, white blood cells (WBC), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR), which are used as systemic infection parameters, are not considered as specific markers.…”

Section: Introductionmentioning

confidence: 99%

Is Procalcitonin a more sensitive parameter than other Acute Phase Reactants for early infection in arthroplasty?

Özmeriç¹,

Burç²,

Hürriyet³

et al. 2013

Turk J Bioch

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Elution of Vancomycin and Tobramycin Bonded to Vascular Grafts

Leblebicioğlu

Şencan²,

Günaydın³

et al. 1999

Journal of Chemotherapy

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The elution of vancomycin and tobramycin from vascular grafts sealed with collagen and human blood was studied in vitro. The release of antibiotics was measured in three different types of soaked grafts, including grafts soaked with antibiotic after being sealed with albumin, those sealed with antibiotic and albumin mixture and those impregnated with fresh blood and antibiotic mixture. Each antibiotic was tested at two different concentrations, i.e. 5 mg/ml and 10 mg/ml for vancomycin and 2 mg/ml and 5 mg/ml for tobramycin. The eluted antibiotic concentrations were determined by the fluorescence polarization immunoassay. Initially large quantities of antibiotics were quickly eluted, depending on the amount of antibiotic mixture. A measurable amount of vancomycin was released for 3 days. There was no difference between the elution kinetics of the two antibiotics from the three different soaked grafts (p>0.05). Antibiotic-soaked grafts provided zones of inhibition against Staphylococcus aureus on Trypticase soy agar plate for up to 24 h. These results suggest that local application for 24 h of vancomycin or tobramycin with vascular grafts may be effective to prevent graft infection as shown by the fluorescence polarization immunoassay.

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In-vitro release of vancomycin and netilmicin from bone cement

Cited by 5 publications

References 6 publications

Enterococcal joint prosthesis infection

Enterococcal joint prosthesis infection

Is Procalcitonin a more sensitive parameter than other Acute Phase Reactants for early infection in arthroplasty?

Elution of Vancomycin and Tobramycin Bonded to Vascular Grafts

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