In vitro release kinetics of biologically active transforming growth factor-β1 from a novel porous glass carrier

Nicoll, Steven B.; Radin, S.; Santos, Eric M.; Tuan, Rocky S.; Ducheyne, Paul

doi:10.1016/s0142-9612(97)00008-2

Cited by 129 publications

(64 citation statements)

References 39 publications

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“…They have been studied for biomedical applications that include tissue, cell and enzyme encapsulation and controlled release of drugs [2,3,[6][7][8][9][10][11][12][13]. Derived from a metal alkoxide precursor, the sol is produced through a hydrolysis and polycondensation reaction [14].…”

Section: Q3mentioning

confidence: 99%

“…Due to the mild processing conditions, high concentrations of many types of biologically active agents can be incorporated in the liquid sol. The agents are embedded in the matrix of the gel, which after condensation and drying becomes a porous, glassy solid [2,3,[9][10][11][12][13]. Data show that controlled release of antibiotics, proteins, and growth factors is possible from this porous material [2,[9][10][11][12][13].…”

Section: Q3mentioning

confidence: 99%

“…The agents are embedded in the matrix of the gel, which after condensation and drying becomes a porous, glassy solid [2,3,[9][10][11][12][13]. Data show that controlled release of antibiotics, proteins, and growth factors is possible from this porous material [2,[9][10][11][12][13]. These studies also demonstrate that the release is dependent on synthesis parameters such as the molar ratio of silica precursor to water, type of precursor and the concentration of bioactive drugs [2,10,11].…”

Section: Q3mentioning

confidence: 99%

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The controlled release of drugs from emulsified, sol gel processed silica microspheres

2009

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Controlled release silica sol gels are room temperature processed, porous, resorbable materials with generally good compatibility. Many molecules including drugs, proteins and growth factors can be released from sol gels and the quantity and duration of the release can vary widely. Processing parameters render these release properties exquisitely versatile. The synthesis of controlled release sol gels typically includes acid catalyzed hydrolysis to form a sol with the molecules included. This is then followed by casting, aging and drying. Additional steps such as grinding and sieving are required to produce sol gel granules of a desirable size. In this study, we focus on the synthesis of sol gel microspheres by using a novel process with only two steps. The novelty is related to acid-base catalysis of the sol prior to emulsification. Sol gel microspheres containing either vancomycin (antibiotic) or bupivacaine (analgesic) were successfully synthesized using this method. Both drugs showed controlled, load dependent and time dependent release from the microspheres. The in vitro release properties of sol gel microspheres were remarkably different from those of sol gel granules produced by grinding and sieving. In contrast to a fast, short-term release from granules, the release from microspheres was slower and of longer duration. In addition, the degradation rate of microspheres was significantly slower than that of the granules. Using various mathematical models, the data reveal that the release from sol gel powder is governed by two distinct phases of release. In addition, the release from emulsified microspheres is delayed, a finding that can be attributed to differences in surface properties of the particles produced by emulsification and those produced by casting and grinding. The presented results represent an excellent data set for designing and implementing preclinical studies. t r a c tControlled release silica sol gels are room temperature processed, porous, resorbable materials with generally good compatibility. Many molecules including drugs, proteins and growth factors can be released from sol gels and the quantity and duration of the release can vary widely. Processing parameters render these release properties exquisitely versatile. The synthesis of controlled release sol gels typically includes acid catalyzed hydrolysis to form a sol with the molecules included. This is then followed by casting, aging and drying. Additional steps such as grinding and sieving are required to produce sol gel granules of a desirable size. In this study, we focus on the synthesis of sol gel microspheres by using a novel process with only two steps. The novelty is related to acid-base catalysis of the sol prior to emulsification. Sol gel microspheres containing either vancomycin (antibiotic) or bupivacaine (analgesic) were successfully synthesized using this method. Both drugs showed controlled, load dependent and time dependent release from the microspheres. The in vitro release properties of sol gel microspher...

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Section: Q3mentioning

confidence: 99%

Section: Q3mentioning

confidence: 99%

Section: Q3mentioning

confidence: 99%

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The controlled release of drugs from emulsified, sol gel processed silica microspheres

2009

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“…Ceramics as drug delivery systems were basically in the form of porous materials and using the well-known ceramics mentioned above. As proposed by Ducheyne and co-workers (Nicoll et al, 1997;Santos et al, 1998Santos et al, , 1999, sol-gel technology for the formation of silica-based xerogels, which allows the introduction of functional proteins into glasslike materials, is a very interesting strategy that couples the bioactive behaviour of these systems with drug delivery capability and the additional ability to tailor other properties. Another major advantages relate to room temperature processing without the need for solvents.…”

Section: Incorporation and Releasementioning

confidence: 99%

Materials in particulate form for tissue engineering. 1. Basic concepts

Silva

Ducheyne

Reis

2007

J Tissue Eng Regen Med

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For biomedical applications, materials small in size are growing in importance. In an era where 'nano' is the new trend, micro-and nano-materials are in the forefront of developments. Materials in the particulate form aim to designate systems with a reduced size, such as micro-and nanoparticles. These systems can be produced starting from a diversity of materials, of which polymers are the most used. Similarly, a multitude of methods are to produce particulate systems, and both materials and methods are critically reviewed here. Among the varied applications that materials in the particulate form can have, drug delivery systems are probably the most prominent, as these have been in the forefront of interest for biomedical applications. The basic concepts pertaining to drug delivery are summarized, and the role of polymers as drug delivery systems conclude this review. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE R E V I E W A R T I C L E

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“…Esta última técnica tem a vantagem de evitar uma possível ligação estável da substância à rede da sílica, o que reduziria a liberação do medicamento. A liberação de uma grande variedade de substâncias, incluindo esteróides 51 , fármacos anti-cancerígenos 52 , antibióticos [53][54][55] , anticoagulantes 56 , fármacos coronarianas 57 , fatores de crescimento 58 e proteínas 59 , tem sido testada. Em geral, a velocidade de liberação das espécies aprisionadas Tabela 1.…”

Section: Emprego Do Método Sol-gel Para Producão De Biocerâmicasunclassified

Cerâmicas bioativas: estado da arte

Andrade

Domingues

2006

Quím. Nova

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Recebido em 13/10/04; aceito em 27/4/05; publicado na web em 24/8/05 BIOACTIVE CERAMICS: STATE OF THE ART. Bioactive glasses undergo corrosion with leaching of alkaline ions when exposed to body fluids. This results in the spontaneous formation of a layer of hydroxyapatite (HA) , the mineral component of natural bone, which in turn can induce bone growth in vivo. This paper describes the different types of bioactive glasses, the characterization methods currently used, and the main factors that influence their bioactivity. Nucleation and crystallization, the main mechanisms involved in the formation of hydroxyapatite, Ca 10 (PO 4 ) 6 (OH) 2, are discussed as a function of the chemical composition and the reactivity of the surface of the material. Finally, promising applications are considered.Keywords: sol-gel; bioactive glass; in vitro tests. INTRODUÇÃOO aprimoramento técnico-científico na área médica faz-se necessário devido à busca incansável do ser humano pela longevidade e por padrões de vida superiores, o que gera a necessidade de alternativas para reparo e substituição de tecidos vivos vitimados por traumas, patologias e fraturas, dentre outros 1 . Devido a problemas como disponibilidade limitada, dificuldade de armazenamento e um tempo cirúrgico maior dos enxertos autógenos e alógenos, os pesquisadores buscam materiais sintéticos que facilitem a reparação óssea visando o restabelecimento rápido das funções fisiológicas 2 . Dentre os materiais sintéticos usados para biorreparação do tecido ósseo, as cerâmicas, também conhecidas como biocerâmicas, são as mais empregadas. As biocerâmicas apresentam-se na forma de pós, revestimentos ou próteses usados para reparo, aumento ou substituição de tecidos doentes ou danificados, como ossos, juntas e dentes 3,4 . Embora muitas composições de cerâmicas tenham sido testadas para uso médico, poucas são usadas clinicamente. Destas, pode-se citar a Al 2 O 3 e ZrO 2, usadas, inicialmente, na substituição total de juntas dos quadris e fêmur; os fosfatos de cálcio usados como revestimento de ligas metálicas e em formato de granulados ou de pequenas peças porosas para reparo ósseo; os vidros e vitrocerâmicas bioativos usados para substituição e reparo de ossículos do ouvido interno, dentes e vértebras 3,5 . CERÂMICAS BIOATIVAS (CBAs)Atualmente, o uso de cerâmicas bioativas como implantes ósse-os tem sido muito estudado. O termo bioatividade foi usado primeiro para descrever a habilidade que certas composições de vidros, desenvolvidos no fim da década de 60 e início da de 70 6 , têm de se ligarem ao tecido ósseo circundante ao implante, induzindo a formação de uma camada de hidroxiapatita (HA) em sua superfície. Hoje, sabe-se que outros materiais cerâmicos como a HA sintética, o fosfato tri-cálcio sinterizado e algumas vitro-cerâmicas 7-11 também podem ser bioativos sob certas condições de síntese.Sabe-se que a superfície de uma cerâmica bioativa (CBA) induz a biomineralização do fosfato de cálcio (HA) através da interação com o plasma sanguíneo, que é a primeira fase que int...

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In vitro release kinetics of biologically active transforming growth factor-β1 from a novel porous glass carrier

Cited by 129 publications

References 39 publications

The controlled release of drugs from emulsified, sol gel processed silica microspheres

The controlled release of drugs from emulsified, sol gel processed silica microspheres

Materials in particulate form for tissue engineering. 1. Basic concepts

Cerâmicas bioativas: estado da arte

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