In vitro release kinetics and physical, chemical and mechanical characterization of a POVIAC ® /CaCO 3 /HAP-200 composite

Aragón, Javier; González, Ramón; Fuentes, Gastón; Palin, Luca; Croce, Gianluca; Viterbo, D.

doi:10.1007/s10856-011-4514-1

Cited by 4 publications

(2 citation statements)

References 63 publications

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“…This indicates that the formulation acts as a polymeric matrix from which FOS is liberated in GIT fluids (Korsmeyer et al, 1983). Besides, parameter n was lower than 0.5 in every situation, meaning that the antibiotic is being released from a swollen matrix and from pores filled with water (Aragón Fernández et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Potential interactions between an oral fosfomycin formulation and feed or drinking water: Impact on bioavailability in piglets

Decundo

Dieguez

Amanto

et al. 2021

Vet Pharm & Therapeutics

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Feed and drinking water are the most frequently used vehicles for administration of antibiotics in intensive pig production. Interactions of drugs with feed and water components may affect dissolution and bioavailability. Therefore, antibiotic formulations should be tested in order to assure their suitability for oral use. In this study, an oral fosfomycin (FOS) formulation was evaluated considering dissolution in water (soft and hard), release kinetics from feed in simulated gastrointestinal fluids and bioavailability after oral administration blended into feed or dissolved in water (soft and hard), to fed and fasted piglets. FOS reached immediate dissolution in soft and hard water. The presence of feed significantly decreased antibiotic dissolution in simulated intestinal medium. Bioavailability was lower when feed was used as a vehicle for FOS administration than when the drug was dissolved in water (soft or hard). The fed or fasted condition of piglets did not affect bioavailability. Probably, FOS interactions with feed components alter its dissolution in the gastrointestinal tract, and only a fraction of the dose would be available for absorption. This information must be considered to support decisions on eligibility of antibiotic pharmaceutical formulations and the vehicle for their administration in order to pursue a responsible use of antibiotics.

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Section: Discussionmentioning

confidence: 99%

Potential interactions between an oral fosfomycin formulation and feed or drinking water: Impact on bioavailability in piglets

Decundo

Dieguez

Amanto

et al. 2021

Vet Pharm & Therapeutics

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“…The results obtained of the release of ions from the coating show that the release occurs very slowly. This release rate suggests that there is a good interaction between the resin and the CuSe-GA nanoparticles, since if there were weak interactions between them, we would observe a sudden initial release [40,43], which is not optimal for applications such as coatings or paintings. These results are in agreement with the findings found in FTIR.…”

mentioning

confidence: 98%

Nanostructured Copper Selenide Coatings for Antifouling Applications

Mancillas-Salas,

Ledón-Smith,

Pérez-Álvarez

et al. 2024

Polymers

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The accumulation of microorganisms, plants, algae, or small animals on wet surfaces that have a mechanical function causes biofouling, which can result in structural or other functional deficiencies. The maritime shipping industry must constantly manage biofouling to optimize operational performance, which is a common and long-lasting problem. It can occur on any metal structure in contact with or submerged in ocean water, which represents additional costs in terms of repairs and maintenance. This study is focused on the production of antifouling coatings, made with nanoparticles of copper selenide (CuSe NPs) modified with gum arabic, within a water-base acrylic polymeric matrix. During the curing of the acrylic resin, the CuSe NPs remain embedded in the resin, but this does not prevent the release of ions. The coatings released copper and selenium ions for up to 80 days, and selenium was the element that was released the most. The adhesion of film coatings to metallic substrates showed good adhesion, scale 5B (ASTM D3359 standard). Antimicrobial activity tests show that the coatings have an inhibitory effect on Escherichia coli and Candida albicans. The effect is more noticeable when the coating is detached from the substrate and placed on a growing medium, compared to the coating on a substrate. Scanning electron microscopy (SEM) observations show that nanostructured CuSe coatings are made up of rod-shaped and spherical particles with an average particle size of 101.6 nm and 50 nm, respectively. The energy dispersive X-ray spectroscopy (EDS) studies showed that the ratio of selenium nanoparticles is greater than that of copper and that their distribution is homogeneous.

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Biomaterials and Bioceramics—Part 2: Nanocomposites in Osseointegration and Hard Tissue Regeneration

Choi

2022

Innovative Bioceramics in Translational Medicine I

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In vitro release kinetics and physical, chemical and mechanical characterization of a POVIAC ® /CaCO 3 /HAP-200 composite

Cited by 4 publications

References 63 publications

Potential interactions between an oral fosfomycin formulation and feed or drinking water: Impact on bioavailability in piglets

Potential interactions between an oral fosfomycin formulation and feed or drinking water: Impact on bioavailability in piglets

Nanostructured Copper Selenide Coatings for Antifouling Applications

Biomaterials and Bioceramics—Part 2: Nanocomposites in Osseointegration and Hard Tissue Regeneration

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