In vitro regulation of cell behavior by calcium phosphates synthesized by the mechanochemical method

Abstract

Biological activity of eight hydroxyapatite powders synthesized by the mechanochemical method was studied in vitro. Introduction of copper and zinc atoms into synthetic hydroxyapatite structure promotes cell adhesion. Hydroxyapatites obtained by the mechanochemical method are promising base for a new class of materials and coatings with regulated bioactivity for orthopedics and traumatology.

Preparation and characterization of a novel strontium-containing calcium phosphate cement with the two-step hydration process

“…Some authors have reported that the biocompatibility of the biomaterial is improved by a mechanochemical method [4,20]. Through mechanochemical activation, hydroxyapatite (HA) and its derivatives are obtained [21][22][23][24][25][26][27][28].…”