In vitro protective effects of Thymus quinquecostatus Celak extracts on t-BHP-induced cell damage through antioxidant activity

Kim, Yon-Suk; Lee, Seung-Jae; Hwang, Jin-Woo; Kim, Min Jung; Kim, Seong‐Eun; Kim, Ee-Hwa; Moon, Sang-Ho; Jeon, Byung-Tae; Park, Pyo-Jam

doi:10.1016/j.fct.2012.08.015

Cited by 33 publications

(17 citation statements)

References 33 publications

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“…The phenolic compound concentration of extracts from boysenberry, black currant, and blueberry were determined using a protocol similar to that of the Folinciocalteu assay [10]. Briefly, 0.1 mL of extracts from boysenberry, black currant, and blueberry were mixed with 50 μL of 50% Folin-Ciocalteau reagent and 150 μL of 20% sodium carbonate (Na 2 CO 3 ).…”

Section: Determination Of Total Phenolic Compound Concentrationmentioning

confidence: 99%

Protective Effects of Berry Extracts on Hydrogen Peroxide-induced Rat Brain Neuronal Cell Damage in vitro

Jeong¹,

Jang²,

Kum³

et al. 2014

JFNR

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The purpose of this study was to evaluate the antioxidative activities and protective effects of boysenberry, black currant, and blueberry extracts on neuronal cells. We found that berry extracts had different levels of antioxidant efficacy in various assays, including cell viability assays using 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl-tetrazoliumbromide (MTT). In addition, reactive oxygen species (ROS) were measured using 2',7'-dichlorofluorescein diacetate (DCF-DA) and flow cytometry analysis. Fruit extracts possessed strong antioxidant activities as measured using the malondialdehyde (MDA) assays. These extracts effectively inhibited lipid peroxidation. Black currant fruit extract significantly reduced intracellular ROS accumulation resulting from hydrogen peroxide treatment in PC12 cells. Black currant fruit more effectively inhibited lactate dehydrogenase (LDH) release into the medium than other tested fruit extracts did. The present results indicate that fruit extracts have the potential to protect neurons from hydrogen peroxide-induced cell damage and should be considered as a prospective functional food and therapeutic product.

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Section: Determination Of Total Phenolic Compound Concentrationmentioning

confidence: 99%

Protective Effects of Berry Extracts on Hydrogen Peroxide-induced Rat Brain Neuronal Cell Damage in vitro

Jeong¹,

Jang²,

Kum³

et al. 2014

JFNR

Self Cite

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“…Thus, removal of excess ROS or suppression of their generation by antioxidants may be effective in preventing oxidative cell death induced by ethanol. Studies have been conducted to investigate the antioxidant effects of natural products and their findings showed significant results in ROS production (21,22). In the present study, we have shown from the results obtained that COS is a potential source that can be used in medical-or pharmaceutical-related fields.…”

Section: Discussionmentioning

confidence: 55%

Chitooligosaccharides inhibit ethanol-induced oxidative stress via activation of Nrf2 and reduction of MAPK phosphorylation

Luo

Xiao

et al. 2014

Oncology Reports

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Chitooligosaccharides (COS) are hydrolyzed products of chitosan and have been proven to exhibit various biological functions. The aims of this study were to investigate the mechanisms underlying the hepatoprotective effects of COS against ethanol-induced oxidative stress in vitro. Human L02 normal liver cells were pretreated with COS (0.25, 0.5 and 1.0 mg/ml) and then hepatotoxicity was stimulated by the addition of ethanol (80 mM). Pretreatment with COS protected L02 cells from ethanol-induced cell cytotoxicity through inhibition of reactive oxygen species generation. Furthermore, ethanol-induced lipid peroxidation and glutathione depletion was inhibited by COS. The antioxidant potential of COS was correlated with the induction of antioxidant genes including HO-1, NQO1 and SOD via the transcriptional activation of nuclear factor erythroid-2‑related factor-2 (Nrf2). Additionally, the protective effects of COS against ethanol were blocked by Nrf2 knockdown. Moreover, signal transduction studies showed that COS was able to suppress the ethanol-induced phosphorylation of p38 MAPK, JNK and ERK. In conclusion, the COS-mediated activation of Nrf2 and reduction of MAPK phosphorylation may be important for its hepatoprotective action.

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“…According to many reports, there is a highly positive relationship between polyphenols and flavonoids, and anti-oxidant activities in many plant species (Kim et al, 2012;Bouaziz et al, 2015). So, based on the obtained results, it is highly possible that the polyphenols and flavonoids contents may contribute to the observed anti -oxidant activity in DPPH free radical scavenging activity, as indicated by the good correlation coefficient Concentration (mg/kg) (R²=0.50).…”

Section: Discussionmentioning

confidence: 56%

In vitro anti-oxidant, hypotensive and diuretic activities of Origanum glandulosum in rat

Bouaziz

Khennouf

Zarga

et al. 2019

Bangladesh J Pharmacol

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In vitro anti-oxidant, hypotensive and diuretic activities of Origanum glandulosum in rat BJP Thus, much attention has been paid to the study of medicinal plants, including the screening of natural bioactive compounds such as phenolic compounds with the ability to cure, prevent the progression of many diseases (Yadegarinia et al., 2006) and the exploration of traditional medicines may reveal new treatment options to increase the therapeutic arsenal by the discovery of novel medicines and to offer lower cost alternatives in developing countries that increasingly AbstractThe objective of this study was to evaluate the in vitro anti-oxidant, hypotensive and the diuretic activities of Origanum glandulosum leaves in rat. Chemical analysis revealed the isolation of katuranin and 5-isopropyl-3methylphenol. Ethyl acetate extract possessed highest scavenging activity against DPPH and hydroxyl radicals. Intravenous administration of extracts (0.04 to 12 mg/kg body weight) dose-dependently decreased the blood pressure (systolic, diastolic and mean) of the anesthetized rat. Methanol extract showed dose-dependent diuretic activity by increasing the urine output (77%) and the urinary excretion of sodium and potassium. In conclusion, this study supports the use of O. glansulosum in traditional medicine as hypotensive and diuretic agents. Article Info

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In vitro protective effects of Thymus quinquecostatus Celak extracts on t-BHP-induced cell damage through antioxidant activity

Cited by 33 publications

References 33 publications

Protective Effects of Berry Extracts on Hydrogen Peroxide-induced Rat Brain Neuronal Cell Damage in vitro

Protective Effects of Berry Extracts on Hydrogen Peroxide-induced Rat Brain Neuronal Cell Damage in vitro

Chitooligosaccharides inhibit ethanol-induced oxidative stress via activation of Nrf2 and reduction of MAPK phosphorylation

In vitro anti-oxidant, hypotensive and diuretic activities of Origanum glandulosum in rat

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