In vitro prolonged gastric residence and sustained release of atenolol using novel clay polymer nanocomposite

Lal, Seema; Datta, Monika

doi:10.1016/j.clay.2015.06.017

Cited by 31 publications

(15 citation statements)

References 51 publications

(51 reference statements)

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“…Nanoparticles of atenolol in PLGA and montmorillonite promoted sustained release of the drug compared to the commercial presentation with conventional release. The composite had prolonged stability in stomach media, leading to greater absorption and bioavailability (32).…”

Section: Systems Obtained From Polymers and Claysmentioning

confidence: 99%

“…New release profile favors the treatment of arterial hypertension with a reduced initial release of the drug that is also extended. This change reduces the frequency of administration for chronic therapy, improving patient compliance (32).…”

Section: Polymersmentioning

confidence: 99%

“…Preparation of PLGA/ montmorillonite nanoparticles also extended gastric retention time of atenolol, reducing the initial rapid release characteristic of the systems obtained with this polymer. Because the addition of clay increases the stability of PLGA in acid, as well as the intercalation of the drug offers a more tortuous pathway for its release (32).…”

Section: Modified Drug Release Systems: Improvements Derived From Orgmentioning

confidence: 99%

“…These polymers were employed predominantly as matrices (22,26,32,35,49,66,74,89), but in some cases formed the composite coating (64,70,71).…”

Section: Polymersmentioning

confidence: 99%

“…A host of different constituents were used in the polymeric part of these hybrid materials, ranging from chitosan (14,28,36-38,56,72), alginate (51,62,71), guar gum (22) and hyaluronic acid (72), to synthetic polyvinyl alcohol (48,49), poly (lactic-co-glycolic acid) (32,57,69), polyurethane (4,6,21,34,35), and poly(L-lactic acid) (5,8,63), among others. These polymers were employed predominantly as matrices (22,26,32,35,49,66,74,89), but in some cases formed the composite coating (64,70,71).…”

Section: Polymersmentioning

confidence: 99%

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Clay and Polymer-Based Composites Applied to Drug Release: A Scientific and Technological Prospection

Meirelles

Raffin

2017

J Pharm Pharm Sci

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-There has been a growing trend in recent years for the development of hybrid materials, called composites, based on clay and polymers, whose innovative properties render them attractive for drug release. The objective of this manuscript was to conduct a review of original articles on this topic published over the last decade and of the body of patents related to these carriers. A scientific prospection was carried out spanning the period from 2005 to 2015 on the Web of Science database. The technological prospection encompassed the United States Patent and Trademark Office, the European Patent Office, the World International Patent Office and the National Institute of Industrial Property databases, filtering patents with the code A61K. The survey revealed a rise in the number of publications over the past decade, confirming the potential of these hybrids for use in pharmaceutical technology. Through interaction between polymer and clay, the mechanical and thermal properties of composites are enhanced, promoting stable, controlled drugs release in biological media. The most cited clays analyzed in the articles was montmorillonite, owing to its high surface area and capacity for ion exchange. The polymeric part is commonly obtained by copolymerization, particularly using acrylate derivatives. The hybrid materials are obtained mainly in particulate form on a nanometric scale, attaining a modified release profile often sensitive to stimuli in the media. A low number of patents related to the topic were found. The World International Patent Office had the highest number of lodged patents, while Japan was the country which published the most patents. A need to broaden the application of this technology to include more therapeutic classes was identified. Moreover, the absence of regulation of nanomaterials might explain the disparity between scientific and technological output.

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Section: Systems Obtained From Polymers and Claysmentioning

confidence: 99%

Section: Polymersmentioning

confidence: 99%

Section: Modified Drug Release Systems: Improvements Derived From Orgmentioning

confidence: 99%

“…These polymers were employed predominantly as matrices (22,26,32,35,49,66,74,89), but in some cases formed the composite coating (64,70,71).…”

Section: Polymersmentioning

confidence: 99%

Section: Polymersmentioning

confidence: 99%

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Clay and Polymer-Based Composites Applied to Drug Release: A Scientific and Technological Prospection

Meirelles

Raffin

2017

J Pharm Pharm Sci

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Directly Compressed Tablets: A Novel Drug‐Containing Reservoir Combined with Hydrogel‐Forming Microneedle Arrays for Transdermal Drug Delivery

McAlister¹,

Dutton²,

Vora³

et al. 2020

Adv Healthcare Materials

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Microneedle (MN) patches consist of a hydrogel-forming MN array and a drug-containing reservoir. Drug-containing reservoirs documented in the literature include polymeric films and lyophilized wafers. While effective, both reservoir formulations are aqueous based, and so degradation can occur during formulation and drying for drugs inherently unstable in aqueous media. The preparation and characterization of novel, nonaqueous-based, directly compressed tablets (DCTs) for use in combination with hydrogel-forming MN arrays are described for the first time. In this work, a range of drug molecules are investigated. Precipitation of amoxicillin (AMX) and primaquine (PQ) in conventional hydrogel-forming MN arrays leads to use of poly(vinyl alcohol)-based MN arrays. Following in vitro permeation studies, in vivo pharmacokinetic studies are conducted in rats with MN patches containing AMX, levodopa/carbidopa (LD/CD), and levofloxacin (LVX). Therapeutically relevant concentrations of AMX (≥2 µg mL −1), LD (≥0.5 µg mL −1), and LVX (≥0.2 µg mL −1) are successfully achieved at 1, 2, and 1 h, respectively. Thus, the use of DCTs offers promise to expand the range of drug molecules that can be delivered transdermally using MN patches.

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Clay-Based Conducting Polymer Nanocomposites

Baldissera

Ferreira

2016

Springer Series on Polymer and Composite Materials

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In vitro prolonged gastric residence and sustained release of atenolol using novel clay polymer nanocomposite

Cited by 31 publications

References 51 publications

Clay and Polymer-Based Composites Applied to Drug Release: A Scientific and Technological Prospection

Clay and Polymer-Based Composites Applied to Drug Release: A Scientific and Technological Prospection

Directly Compressed Tablets: A Novel Drug‐Containing Reservoir Combined with Hydrogel‐Forming Microneedle Arrays for Transdermal Drug Delivery

Clay-Based Conducting Polymer Nanocomposites

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