In-vitro phytochemical and pharmacological bio-efficacy studies on Azadirachta indica A. Juss and Melia azedarach Linn for anticancer activity

Malar, T. Renisheya Joy Jeba; Antonyswamy, J.; Vijayaraghavan, Ponnuswamy; Kim, Young Ock; Al-Ghamdi, Abdullah Ahmed; Elshikh, Mohamed S.; Hatamleh, Ashraf Atef; Al-Dosary, Monerah A.; Na, Sae Won; Kim, Hak-Jae

doi:10.1016/j.sjbs.2019.11.024

Cited by 52 publications

(16 citation statements)

References 23 publications

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“…This is the first report on anticancer and anti-inflammatory activities of P. benthamii and B. pacumbis. Previous studies on M. azedarach extract against human urinary bladder carcinoma cells and human breast cancer cells possess no significant inhibition [58,59]. However, some steroids isolated from M. azedarach showed good anticancer potential with low cytotoxicity against human lung cancer cell lines and the human glioma cancer cell line [60].…”

Section: Discussionmentioning

confidence: 94%

In-vitro antioxidant, anti-cancer, and anti-inflammatory activities of selected medicinal plants from western Nepal

et al. 2020

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Background This study was focused on the measurement of anticancer properties of six medicinal plants from western Nepal in three cell lines; HeLa, Hep3B, and HCT116, and anti-inflammatory properties in RAW 264.7 cell line through NO, PGE2, and TNF-α production. In addition, the phytochemical screening, total phenolic, flavonoid content, and antioxidant properties were evaluated. Results The qualitative phytochemical analysis revealed the presence of different secondary metabolite and range of total phenolic and total flavonoid content. The highest antioxidant activities were observed in Bergenia pacumbis against both DPPH (IC50 = 25.97 ± 0.19 μg/mL) and ABTS (IC50 = 14.49 ± 0.40 μg/mL). Furthermore, the highest antiproliferative effect against cervical, liver, and colon cancer cell lines were observed in Melia azedarach as IC50 values of 10.50, 5.30, and 1.57 μg/mL respectively, while the strongest anti-metastatic potential on liver cancer cell line was found in Pleurospermum benthamii. In addition, P. benthamii showed the most potent anti-inflammatory effect in RAW264.7 murine macrophage cells. Conclusion This study provided the evidence for M. azedarach and P. benthamii to have great anticancer potential and finding builds the enough scientific backgrounds in future to isolate and purify the bioactive compounds for further applications.

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Section: Discussionmentioning

confidence: 94%

In-vitro antioxidant, anti-cancer, and anti-inflammatory activities of selected medicinal plants from western Nepal

et al. 2020

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“…The synthesized nanoparticles have the ability to inhibit the growth of cell lines HeLa and DlD1. The anticancer activity of nanoparticles has been reported previously (Valsalam et al, 2019;Venkatadri et al, 2020;Lydia et al, 2020;Malar et al, 2020).…”

Section: Anticancer Activity Of Iron Npsmentioning

confidence: 82%

Green synthesis of iron nanoparticles using aqueous extract of Turbinaria conoides (J. Agardh) and their anticancer properties

Bensy

Christobel

2021

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Marine macroalgae produce numerous bioactive compounds with potential pharmacological properties. In this study, macroalga was collected from the Gulf of Mannar, India and identified as, Turbinaria conoides (J. Agardh). The aqueous extract of T. conoides was used to synthesize iron nanoparticles (NPs). The synthesized iron NPs were characterized by X –ray diffraction analysis, Scanning Electron Microscopy, and Transmission Electron Microscopy. The synthesized NPs showed potent activity against DLD1 and HeLa cell lines.

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“…A GC-MS analysis of the hexane extracts of chinaberry leaves showed a highly complex profile that contained ketones, fatty acid derivatives, ethers, 1,3-dipalmitate, methyl esters, 7,8-dihydrocarpesterol, and 2-undecanol ( Habib et al 2017 ). The methanolic fraction of the aerial parts of chinaberry contained steroids, anthraquinones, phenolics, flavonoids, and tannins ( Malar et al 2020 ). The metabolites of chinaberry flowers included branched and n-hydrocarbons, fatty acids, aromatics, fatty acid methyl esters, polyisoprenoids, and fatty alcohols ( Muhammad et al 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Chemical Components of Aqueous Extracts of Melia azedarach Fruits and Their Effects on The Transcriptome of Staphylococcus aureus

Peng

Wang

et al. 2021

Polish Journal of Microbiology

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Staphylococcus aureus is the causative agent of numerous and varied clinical infections. Crude aqueous extracts of Melia azedarach fruits inhibit the planktonic growth and initial biofilm formation of S. aureus in a dose-dependent manner. Moreover, the biofilm topologies became sparse and decreased as the concentration of the aqueous extracts increased. RNA-Seq analyses revealed 532 differentially expressed genes (DEGs) after S. aureus exposure to 0.25 mg/l extracts; 319 of them were upregulated, and 213 were downregulated. The majority of DEGs were categorized into abundant sub-groups in the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Finally, untargeted UHPLC-MS/MS analyses of the aqueous extracts of M. azedarach fruits demonstrated a highly complex profile in positive and negative electrospray ionization modes. The extracts primarily consisted of lipids and lipid-like molecules, organic acids and their derivatives, phenylpropanoids, polyketides, organoheterocyclic compounds, and benzenoids, annotated by abundant lipid maps and KEGG pathways. Overall, this study provides evidence that the aqueous extracts of M. azedarach fruits can control S. aureus infections and sought to understand the mode of action of these extracts on S. aureus.

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In-vitro phytochemical and pharmacological bio-efficacy studies on Azadirachta indica A. Juss and Melia azedarach Linn for anticancer activity

Cited by 52 publications

References 23 publications

In-vitro antioxidant, anti-cancer, and anti-inflammatory activities of selected medicinal plants from western Nepal

In-vitro antioxidant, anti-cancer, and anti-inflammatory activities of selected medicinal plants from western Nepal

Green synthesis of iron nanoparticles using aqueous extract of Turbinaria conoides (J. Agardh) and their anticancer properties

Chemical Components of Aqueous Extracts of Melia azedarach Fruits and Their Effects on The Transcriptome of Staphylococcus aureus

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