In vitro nerve repair — in vivo. The reconstruction of peripheral nerves by entubulation with biodegradeable glass tubes — a preliminary report

Gilchrist, T.; Glasby, M. A.; Healy, D. M.; Kelly, George E; Lenihan, D. V.; McDowall, K.L.; Miller, I.A.; Myles, L. M.

doi:10.1054/bjps.1997.0243

Cited by 53 publications

(49 citation statements)

References 21 publications

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“…Furthermore, various authors reported the use of these materials containing different intraluminal substances and have revealed strong influence on neural regeneration 4, 6, 12–14. However, several disadvantages have resulted when a synthetic prosthesis (silicone) is kept on the injury site for a long time; it often induces severe scarring and fibrosis that leads to nerve dysfunction 9, 15. For this reason, biodegradable biopolymer prostheses offer advantages over silicone ones, because a second surgery is not required to remove them, producing better results than those of a nerve graft for larger nerve gaps, with valuable biological effects resulting from their use as drug‐ or cell‐delivery devices 5, 12, 13, 16–18…”

Section: Introductionmentioning

confidence: 99%

Facial nerve regeneration through progesterone‐loaded chitosan prosthesis. A preliminary report

et al. 2003

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Biodegradable nerve guides have represented new treatment alternatives for nerve repairing. They are gradually biodegradable, exert biological effects directly to the injured nerve, and act as drug- or cell-delivery devices. Furthermore, progesterone (PROG) has been demonstrated to promote injured peripheral nerve regeneration. In this study, it was hypothesized that PROG delivered from chitosan prostheses provides better facial nerve regenerative response than chitosan prostheses with no PROG. As there are no reports on the use of the former as nerve-guide material in the regeneration of injured nerves, this is the main objective of the present work. Chitosan prostheses containing PROG were used to bridge 10-mm gaps in rabbit facial nerves. The regenerated nerves were evaluated 45 days after implantation in animals with the use of light microscopy and morphometric analysis. Gas chromatography was used in order to quantify PROG content in prosthesis prior to and after implantation in subcutaneous tissue at different periods of up to 60 days. In addition, the prosthesis walls were evaluated with histological techniques in order to assess their integrity and the surrounding tissue reaction. Chitosan prostheses allowed PROG release during the time needed for nerve regeneration. At 45 days myelinated nerve fibers were observed in both the proximal and distal stumps. This parameter and the N ratio were higher in the progesterone-treated group when compared to that of the vehicle control. Findings indicate that chitosan prostheses were useful in nerve regeneration, acting as a long-lasting PROG delivery device a faster nerve regeneration.

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Section: Introductionmentioning

confidence: 99%

Facial nerve regeneration through progesterone‐loaded chitosan prosthesis. A preliminary report

et al. 2003

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“…Even silicone tubes [57,58,59,60,61,62,63] or glass fibres [64,65,66] have been reported. Some of these materials are already used in several clinical human trials (Table 1).…”

Section: Revascularization and Physical Propertiesmentioning

confidence: 99%

“…At the time of assessment all of the glass tubes were found to have dissolved completely. Nerve regeneration had taken place to a degree at least as effective as seen in nerves of a similar size repaired by conventional means [66]. Since then, no further reports about glass-nerve tubes could be detected, but in 2007 the same authors used a flexible biodegradable glass fibre wrap for repair of divided median nerves of sheep and compared it to microsurgical epineurial repair.…”

Section: Glass Fibre Graftsmentioning

confidence: 99%

Biocompatibility of Different Nerve Tubes

2009

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Bridging nerve gaps with suitable grafts is a major clinical problem. The autologous nerve graft is considered to be the gold standard, providing the best functional results; however, donor site morbidity is still a major disadvantage. Various attempts have been made to overcome the problems of autologous nerve grafts with artificial nerve tubes, which are “ready-to-use” in almost every situation. A wide range of materials have been used in animal models but only few have been applied to date clinically, where biocompatibility is an inevitable prerequisite. This review gives an idea about artificial nerve tubes with special focus on their biocompatibility in animals and humans.

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“…The wrap used in the present study is made from Corglaes (Giltech Ltd, 12 North Harbour Estate, Ayr, Scotland, UK), a biodegradable, biocompatable glass, which when used in the form of a solid tube, was shown to support the regeneration of divided facial nerves in sheep [5].…”

Section: Introductionmentioning

confidence: 99%

An evaluation using techniques to assess muscle and nerve regeneration of a flexible glass wrap in the repair of peripheral nerves

Jeans

Healy

Gilchrist

How to Improve the Results of Peripheral Nerve Surgery

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SummaryIn this study a flexible biodegradable wrap is compared with microsurgical epineurial suturing in the repair of cleanly divided peripheral nerves. Five groups of twelve sheep were used; one control group and four neurotmesis and repair groups. The four repair groups were;1. Epineurial suture repair using a microscope and 9=0 polyamide; 2. Wrap secured by Tisseel glue; 3. Wrap secured by polycaprolactone glue; 4. Wrap secured by suturing.Regeneration of the median nerve was assessed by electromyography, nerve conduction studies, wet muscle mass measurements, and morphometry.The results suggested that nerve regeneration in the wrap þ Tisseel glue group was as good as that in the epineurial repair group. The use of polycaprolactone glue is not recommended in nerve repair. Placement of the wrap was easy to learn and quick to carry out under direct vision. The wrap used in this study could prove to be a useful alternative to epineurial suturing to repair peripheral nerves and may have a particularly unique role in the developing world and battlefield.

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In vitro nerve repair — in vivo. The reconstruction of peripheral nerves by entubulation with biodegradeable glass tubes — a preliminary report

Cited by 53 publications

References 21 publications

Facial nerve regeneration through progesterone‐loaded chitosan prosthesis. A preliminary report

Facial nerve regeneration through progesterone‐loaded chitosan prosthesis. A preliminary report

Biocompatibility of Different Nerve Tubes

An evaluation using techniques to assess muscle and nerve regeneration of a flexible glass wrap in the repair of peripheral nerves

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