In vitro monitoring of oxidative processes with self-aggregating gold nanoparticles using all-optical photoacoustic spectroscopy

Yasmin, Zannatul; Khachatryan, Edward; Lee, Yuan-Hao; Maswadi, Saher; Glickman, Randolph D.; Nash, Kelly

doi:10.1016/j.bios.2014.09.078

Cited by 14 publications

(7 citation statements)

References 41 publications

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“…Using an all optical opto-acoustic approach as described in earlier reports343536. Pure cobalt ferrite nanoparticles were placed in a glass cuvette that was then filled with liquid (de-ionized water) until reaching the top of the cuvette (~4 ml).…”

Section: Resultsmentioning

confidence: 99%

Magneto-elasto-electroporation (MEEP): In-vitro visualization and numerical characteristics

Betal

Shrestha

Dutta

et al. 2016

Sci Rep

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A magnetically controlled elastically driven electroporation phenomenon, or magneto-elasto-electroporation (MEEP), is discovered while studying the interactions between core-shell magnetoelectric nanoparticles (CSMEN) and biological cells in the presence of an a.c. magnetic field. In this paper we report the effect of MEEP observed via a series of in-vitro experiments using core (CoFe2O4)-shell (BaTiO3) structured magnetoelectric nanoparticles and human epithelial cells (HEP2). The cell electroporation phenomenon and its correlation with the magnetic field modulated CSMEN are described in detail. The potential application of CSMEN in electroporation is confirmed by analyzing crystallographic phases, multiferroic properties of the fabricated CSMEN, influences of d.c. and a.c. magnetic fields on the CSMEN and cytotoxicity tests. The mathematical formalism to quantitatively describe the phenomena is also reported. The reported findings provide insights into the underlying MEEP mechanism and demonstrate the utility of CSMEN as an electric pulse-generating nano-probe in electroporation experiments with a potential application toward accurate and efficient targeted cell permeation.

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Section: Resultsmentioning

confidence: 99%

Magneto-elasto-electroporation (MEEP): In-vitro visualization and numerical characteristics

Betal

Shrestha

Dutta

et al. 2016

Sci Rep

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“…And the localized electromagnetic field is extremely enhanced. Its frequency can be tuned by changing the size, geometry, material, and surrounding dielectrics of the nanoparticles. − Au NPs with advantages of good electrical conductivity, large surface area, high chemical stability, and favorable biocompatibility, have been widely used for biological studies after surface modification . Recently, functionalized Au NPs were also used in SPR sensor for enhancing the sensitivity owing to their high RI and strong plasmon absorption. − For example, antitestosterone-modified and boronic acid-modified Au NPs have been demonstrated for the detection of testosterone and RNA, respectively.…”

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confidence: 99%

Mercaptopyridine-Functionalized Gold Nanoparticles for Fiber-Optic Surface Plasmon Resonance Hg²⁺ Sensing

et al. 2019

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As a highly toxic heavy metal ion, divalent mercuric ion (Hg 2+ ) is one of the most widely diffused and hazardous environmental pollutants. In this work, a simple, portable, and inexpensive fiber-optic sensor based on surface plasmon resonance (SPR) effect was developed for Hg 2+ detection, which takes advantage of 4-mercaptopyridine (4-MPY)-functionalized Au nanoparticles (Au NPs/4-MPY) as a signal amplification tag. Based on the coordination between Hg 2+ and nitrogen in the pyridine moiety, we developed the sensor by self-assembling 4-MPY on Au film surfaces to capture Hg 2+ and then introducing Au NPs/ 4-MPY to generate a plasmonic coupling structure with the configuration of nanoparticle-on-mirror. The coupling between localized SPR increased changes in SPR wavelength, which allowed highly sensitive Hg 2+ sensing in aqueous solution. The sensor exhibited superior selectivity for Hg 2+ detection compared with other common metal ions in water. The sensor's Hg 2+ detection limit is 8 nM under optimal conditions. Furthermore, we validated the sensor's practicality for Hg 2+ detection in tap water samples and demonstrated its potential application for environmental water on-site monitoring.

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“…2a) (26). The morphology of AuNPs manifested a homogenous shape with a mean diameter of 13.09±1.77 nm (Fig.…”

Section: Characterization Of Au-dox-gelmentioning

confidence: 85%

Thermosensitive Hydrogel Co-loaded with Gold Nanoparticles and Doxorubicin for Effective Chemoradiotherapy

Zhang

Wang

et al. 2015

AAPS J

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Abstract. Chemoradiotherapy, as a well-established paradigm to treat various cancers, still calls for novel strategies. Recently, gold nanoparticles (AuNPs) have been shown to play an important role as a radiosensitizer in cancer radiotherapy. The aim of this study was to evaluate the combination of polyethylene glycol (PEG) modified AuNPs and doxorubicin (DOX) to improve cancer chemoradiotherapy, in which the AuNPs was the radiosensitizer and the DOX was the model chemotherapeutic. A Pluronic® F127-based thermosensitive hydrogel (Au-DOX-Gel) loading AuNPs and DOX was developed by Bcold method^for intratumoral injection. The formulation was optimized at a F127 concentration of 22% for Au-DOX-Gel. The release profiles compared to a control group were assessed in vitro and in vivo. Au-DOX-Gel showed sustained release of AuNPs and DOX. The cell viability and surviving fraction of mouse melanoma (B16) and Human hepatocellular liver carcinoma (HepG2) cells were significantly inhibited by the combination treatment of DOX and AuNPs under radiation. Tumor sizes of mice were significantly decreased by Au-DOX-Gel compared to controls. Interestingly, 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay and Ki-67 staining results showed that tumor cell growth and proliferation were inhibited by AuNPs combined with DOX under radiation, suggesting that the radiosensitization activity and combination effects might be caused by inhibition of tumor cell growth and proliferation. Furthermore, the results of skin safety tests, histological observation of organs, and the body weight changes indicated in vivo safety of Au-DOX-Gel. In conclusion, the Au-DOX-Gel developed in this study could represent a promising strategy for improved cancer chemoradiotherapy.

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In vitro monitoring of oxidative processes with self-aggregating gold nanoparticles using all-optical photoacoustic spectroscopy

Cited by 14 publications

References 41 publications

Magneto-elasto-electroporation (MEEP): In-vitro visualization and numerical characteristics

Magneto-elasto-electroporation (MEEP): In-vitro visualization and numerical characteristics

Mercaptopyridine-Functionalized Gold Nanoparticles for Fiber-Optic Surface Plasmon Resonance Hg²⁺ Sensing

Thermosensitive Hydrogel Co-loaded with Gold Nanoparticles and Doxorubicin for Effective Chemoradiotherapy

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In vitro monitoring of oxidative processes with self-aggregating gold nanoparticles using all-optical photoacoustic spectroscopy

Cited by 14 publications

References 41 publications

Magneto-elasto-electroporation (MEEP): In-vitro visualization and numerical characteristics

Magneto-elasto-electroporation (MEEP): In-vitro visualization and numerical characteristics

Mercaptopyridine-Functionalized Gold Nanoparticles for Fiber-Optic Surface Plasmon Resonance Hg2+ Sensing

Thermosensitive Hydrogel Co-loaded with Gold Nanoparticles and Doxorubicin for Effective Chemoradiotherapy

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Product

Resources

About

Mercaptopyridine-Functionalized Gold Nanoparticles for Fiber-Optic Surface Plasmon Resonance Hg²⁺ Sensing