In vitro mimicry of in vivo KPC mutations by ceftazidime-avibactam: phenotypes, mechanisms, genetic structure and kinetics of enzymatic hydrolysis
Siquan Shen,
Chengkang Tang,
Weiwei Yang
et al.
Abstract:Ceftazidime-avibactam (CZA) is employed for the treatment of infections caused by
Klebsiella pneumoniae
carbapenemase-producing
K. pneumoniae
(KPC-KP). Resistance to CZA is frequently linked to point mutations in the
bla
KPC
. We conducted
in vitro
simulations of
in vivo bla
KPC
mutations using CZA. Four pre-therapy KPC-KP isolates (K1, K2, K3, and K4) were evaluated, all… Show more
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