In Vitro Metabolism and In Vivo Pharmacokinetics Profiles of Hydroxy-α-Sanshool
Jie Meng,
Die Qian,
Ruo-Lan Li
et al.
Abstract:Hydroxy-α-sanshool (HAS) is the predominant active compound in Zanthoxylum bungeanum Maxim (ZBM). Our present work was aimed to explore the in vitro metabolism characteristics, and in vivo pharmacokinetic (PK) profile of HAS. Plasma (human), liver microsomes, and hepatocytes (human, monkey, dog, mouse, and rat) were collected for HAS metabolism studies in vitro and HAS elimination rates in liver microsomes and hepatocytes of different species were investigated. In addition, five recombinant human CYP enzymes w… Show more
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