In vitro maturation of oocytes as a laboratory approach to polycystic ovarian syndrome (PCOS): From oocyte to embryo

Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting women of reproductive age, which in some case leads to infertility. This disorder is characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian morphology. Infertile PCOS women that need in vitro fertilization (IVF) have greater risk of ovarian hyperstimulation syndrome (OHSS) if conventional ovarian stimulation is used. In vitro oocyte maturation (IVM) is an alternative technique that prevents OHSS in infertile PCOS women. In the last decade, IVM protocols have improved, particularly with the development of biphasic IVM culture accounting for better pregnancy and live birth rates. This technique has been extended to other treatments like, fertility preservation, when patients have no time, or a contra‐indication for ovarian stimulation, and poor responders. In this review, we will discuss IVM as a viable option for PCOS infertile patients. This article is categorized under: Reproductive System Diseases > Molecular and Cellular Physiology Reproductive System Diseases > Environmental Factors Reproductive System Diseases > Genetics/Genomics/Epigenetics

Success in Parenthood: The In Vitro Maturation Breakthrough in Infertility

“…Opting for IVF for such patients is always a good choice, but it can lead to complications like OHSS in PCOS patients. In vitro maturation is a safer alternative, preventing OHSS by maturing eggs outside the body [5]. A retrospective study by Shalom et al compared treatment outcomes of IVM with IVF in PCOS patients.…”

“…The ovarian stimulation involved in IVF can pose serious problems in PCOS patients, like ovarian hyperstimulation syndrome (OHSS) [4]. To combat that, in vitro maturation (IVM) of oocytes can be done while using stimulation for a very short period [5].…”

Innovative Approaches to Enhancing Oocyte Competence in patients with polycystic ovarian syndrome: A Microfluidic Study with the Impact of FF-MAS on Rescued In Vitro Oocyte Maturation

“…The path to understanding and mitigating the challenges posed by PCOS involves exploring innovative approaches in the eld of ART. In vitro maturation (IVM) of immature oocytes obtained from PCOS patients presents a promising strategy to reduce the associated costs and clinical complications often linked with In Vitro Fertilization (IVF) 5 . While the birth of healthy infants has been reported after IVM procedures, but the pregnancy rates are notably lower compared to oocytes matured in vivo or using other methods.…”

Exosome Therapy and Photobiomodulation Therapy Regulate mi-RNA 21, 155 Expressions, Nucleus Acetylation and Glutathione in a Polycystic Ovary Oocyte: An In Vitro Study

“…PCOS can have a hormonal imbalances contribute to the characteristic symptoms observed in affected individuals, such as irregular menstrual cycles, hirsutism, acne, and infertility. 1 Current studies have displayed that miRNAs play an essential role in the progress of PCOS, including inflammation, and ovarian function. miRNAs prevent their translation into proteins.…”