In vitro lymphocyte response of patients with uterine cancer as related to clinical stage and radiotherapy

Jenkins, Vernon K.; Olson, Michael M.; Ellis, Howard; Dillard, E. Archer

doi:10.1016/s0090-8258(75)80002-3

Cited by 13 publications

(1 citation statement)

References 18 publications

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“…Evidence of im paired cellular immunity assessed either in vivo by skin test reactions or in vitro by stimulation of lymphocytes by specific or non-specific antigens, have shown a variable degree of immunodépression in patients with cancer (11). In our series, a reduction in the total lymphocyte count (below 1.5 X 109/1) was found in 32% of patients.…”

Section: Discussionsupporting

confidence: 39%

Cancer of the Endometrium – a Multiparametric Study

Cauchi¹,

Goriup²,

Riglar³

et al. 1980

Gynecol Obstet Invest

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Haematological and immunological studies were performed on 36 patients with carcinoma of the endometrium prior to treatment. Haematological and coagulation studies, excluding fibrinogen, showed only minimal abnormality. However, tests for acute phase reactant proteins were abnormal in the majority of patients. There was a reduction in T cells in 31% of patients and a reduction in stimulation with PHA and PWM in 84 and 42% of patients, respectively. Autoantibodies to normal tissue antigens were present in half the patients and immune complexes were increased in 45% of patients. Carcinoembryonic antigen and Β₂-microglobulin were increased in 27 and 47% of patients respectively. Although specific tests for endometrial cancer are not yet available, a profile of tests might be of value in the diagnosis and follow-up of patients with the condition.

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Section: Discussionsupporting

confidence: 39%