In vitro leishmanicidal activity and theoretical insights into biological action of ruthenium(II) organometallic complexes containing anti-inflammatories

Ruthenium (II) complex cis-[RuII(ŋ2-O2CC7H7O2)(dppm)2]PF6-hmxbato induces ROS-mediated apoptosis in lung tumor cells producing selective cytotoxicity

“…www.nature.com/scientificreports/DiscussionRuthenium complexes have been extensively explored in recent years mainly due to their antitumor[26][27][28][29] and antiparasitic activities. Some studies of our research group have investigated the cytotoxic potential of different ruthenium complexes against parasites of the Leishmania genus10,30 (Costa et al, 2017;Miranda et al, 2018), and we have also demonstrated the probable cell death mechanism triggered by ruthenium complex called 3-hydroxy-4-methoxybenzoate (hmxbato)-cis-[Ru II (ŋ 2 -O 2 CC 7 H 7 O 2 )(dppm) 2 ]PF 6 against Leishmania (Leishmania) amazonensis promastigotes…”

“…Identification of the intermolecular interactions between the hmxbato ligand and DNA, using the LigPlot program30 .Vol:. (1234567890) Scientific RepoRtS | (2020) 10:15410 | https://doi.org/10.1038/s41598-020-72420-w…”

Biological assays and theoretical density functional theory calculations of Rh(I), Ir(III), and Ru(II) complexes of chiral phosphinite ligand

“…These changes in electron density may alter the biological activity of ligands by affecting intermolecular interactions and lipophilicity. [ 15–17 ] By contrast, the imidazolium‐containing ionic liquid (IL) ligands which essentially consist of an aromatic heterocycle containing two nitrogen atoms, with one in the cationic form, are perhaps the most widely studied in the biological field because of their unique physical and chemical properties. [ 18–20 ] Moreover, extensive biochemical and pharmacological studies have confirmed imidazole as effective compounds in treating various strains of microorganisms.…”

Estudo dos mecanismos de morte induzidos pelo complexo de rutênio hmxbato (cis-[RuII((ŋ2-O2CC7H7O2)(dppm)2]PF6) com atividade contra Leishmania (Leishmania) amazonensis e células tumorais de pulmão – A549

“…Diante desde cenário, os complexos de rutênio têm ganhado destaque devido principalmente, suas propriedades favoráveis (JAYAKUMAR et al, 2018;RILAK SIMOVIĆ et al, 2019) e suas diferentes aplicações terapêuticas, incluindo as atividades antitumoral (BAI et al, 2019(BAI et al, , 2019CARNIZELLO et al, 2016;IRACE et al, 2017;JIANG et al, 2019a;LI et al, 2019) e antiparasitária (COSTA et al, 2017(COSTA et al, , 2019MIRANDA et al, 2018 NAVES et al, 2019).…”

“…Além dos diversos estudos demonstrando o potencial terapêutico antitumoral dos complexos de rutênio, outra atividade biológica crescente que merece destaque é a atividade antiparasitária que estes complexos podem apresentar (COSTA et al, 2017;JELK et al, 2019JELK et al, , 2019MIRANDA et al, 2018;NASCIMENTO et al, 2019 (CHEN et al, 2016;GUPTA et al, 2013;RILAK SIMOVIĆ et al, 2019;SILVA et al, 2018).…”