In vitro investigation of the effect of platelet aggregation ability on the adhesion of platelets to micro-structures

Oota-Ishigaki, Akiko; Maruyama, Osamu; Masuzawa, Toru; Nishida, Masahiro

doi:10.17106/jbr.35.49

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…Recently, the effect of surface micro-structures on cells has attracted tremendous attention, particularly in the aspect of platelet adhesion. 12,13 In contrast, the impact of surface micro-structures on other blood components (such as VWF) has not received as much attention.…”

Section: Introductionmentioning

confidence: 99%

Constructing and evaluating the effect of micron-scale structures on von Willebrand factor damage

Mei,

Jiang,

Huan

et al. 2023

Int J Artif Organs

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The incidence of clinical complication gastrointestinal bleeding has been proved as consequence of von Willebrand factor (VWF) damage after mechanical circulatory support in clinic. Many studies have been conducted to evaluate VWF damage, of which the most studied influencing factors are mechanical factors such as shear stress. However, in addition to mechanical factors, VWF damage may also be affected by interface factors. To address this issue, a roller pump circulation platform was established to investigate the effect of material surface micron-scale structures distribution on VWF damage in flow state. A composite micro-structure combining microngrating and micronpost was designed and constructed on the surface of Si wafer by lithography and reactive ion etching, and detailed characterization of material surfaces was also performed. Then the changes of VWF antigen, VWF ristocetin cofactor activity, and the degradation of high molecular weight VWF on these surfaces were investigated and compared. The results showed that, with the encryption of surface micro-structures arrangement, the material surface tends to be more hydrophobic, which is beneficial to reduce VWF damage. Therefore, in the design of material surface inside the mechanical circulatory support devices, it can be considered to add some surface micro-structures with a certain distribution density to change the hydrophilicity and hydrophobicity, so as to minimize the VWF damage. These results can provide important references for the evaluation of VWF damage caused by interface factors, and aid in designing material surface inside the mechanical circulatory support devices.

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Section: Introductionmentioning

confidence: 99%