In Vitro Investigation of Orthopedic Titanium-Coated and Brushite-Coated Surfaces Using Human Osteoblasts in the Presence of Gentamycin

Ince, Akif; Schütze, Norbert; Hendrich, Christian; Thulĺ, R.; Eulert, J.; Löhr, J. F.

doi:10.1016/j.arth.2007.06.018

Cited by 31 publications

(24 citation statements)

References 47 publications

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“…Many antibacterial coatings, such as antibiotic-loaded coatings, 42 silver-loaded coatings, 43 and some polymer coatings, 44 have shown good potential in recent years, but these coatings are still not widely used in the clinic because of various inherent shortcomings. 46 The inherent shortcomings of silver-loaded coatings are their cytotoxicity 47 and the fact that silver compromises the physical properties of titanium, such as its corrosion resistance. 46 The inherent shortcomings of silver-loaded coatings are their cytotoxicity 47 and the fact that silver compromises the physical properties of titanium, such as its corrosion resistance.…”

Section: Discussionmentioning

confidence: 99%

Quaternised chitosan coating on titanium provides a self-protective surface that prevents bacterial colonisation and implant-associated infections

Peng

Guo

et al. 2015

RSC Adv.

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Implant-related infection is a serious and devastating complication in orthopaedic surgery. The original surfaces of an orthopaedic implant provide ideal substrata for bacterial colonisation and biofilm formation. To reduce this risk, we covalently bonded a titanium implant surface to quaternised chitosan (hydroxypropyltrimethyl ammonium chloride chitosan (HACC)). In vitro, Staphylococcus epidermidis ATCC 35984 was prevented from adhering to and colonising the coated surface. Then, the medullary cavities of rat femora were contaminated with 10 5 colony-forming units/10 ml of S. epidermidis, and titanium rods were simultaneously implanted into the medullary canals. Implant-associated infection occurred in the control group with uncoated titanium implants, while infection was prevented in the group with titanium-coated implants, as revealed by X-ray, blood and bone culture, and histological analyses. Good bone osseointegration was demonstrated around the coated implants. We conclude that quaternised chitosan coating on titanium could provide a self-protective surface that prevents bacterial colonisation and implant-associated infections.

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Section: Discussionmentioning

confidence: 99%

Quaternised chitosan coating on titanium provides a self-protective surface that prevents bacterial colonisation and implant-associated infections

Peng

Guo

et al. 2015

RSC Adv.

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“…The CaP coating used in the present study consists mainly of fine crystalline brushite (Figure ) that shows fast eluation (Table ). In in vitro studies, osteoblasts showed a well‐spread morphology, good proliferation, and osteogenic differentiation on comparable CaP coatings (Becker et al, ; Ince et al, ). Further on a positive effect on bone ingrowth (bone implant contact) and mechanical fixation of TiAl6V4 implants in rabbit and goat in vivo models was reported (Biemond, Eufrásio, Hannink, Verdonschot, & Buma, ; Reigstad et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…360 μm was deposited on the surface of MiPo samples to create samples with a surface porosity (MiPo‐Ti samples). MiPo as well as MiPo‐Ti samples were additionally coated by electrochemical deposition of a calcium phosphate phase (HX®), consisting of >95% of brushite (CaHPO 4 ·2H 2 O) with a Ca/P ratio of 1.1 ± 0.1, to produce the sample types MiPo‐CaP and MiPo‐TiCaP (Ince et al, ). The calcium phosphate coating had a thickness of 15 ± 5 μm; the bond strength was >14 MPa (ASTM F 1147 – 99).…”

Section: Methodsmentioning

confidence: 99%

Evaluation of topographical and chemical modified TiAl6V4 implant surfaces in a weight‐bearing intramedullary femur model in rabbit

et al. 2019

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For cementless total joint replacement implants, the biological response to physicochemical surface characteristics is crucial for their success that depends on fixation by newly formed bone. In this study, the surface of TiAl6V4 (Tilastan®) implants was modified by (a) corundum blasting, (b) corundum blasting followed by electrochemical calcium phosphate (CaP) deposition, and (c) titanium plasma spraying followed by electrochemical CaP deposition. All modifications resulted in a surface roughness suitable to enhance primary implant stabilization and to favor osteoblast adhesion and function; the thin, biomimetic CaP coating is characterized by fast resorbability and served as chemical cue to stimulate osteogenesis. After implantation in a full weight‐bearing rabbit intramedullary distal femur model, osseointegration was investigated after 3, 6, and 12 weeks. For all modifications, new bone formation, occurring from the endosteum of the femoral cortical bone, was observed in direct contact to the implant surface after 3 weeks. At the later time points, maturation of the woven bone into lamellar bone with clearly defined osteons was visible; the remodeling process was accelerated by the CaP coating. The ingrowth of newly formed bone into the pores of the titanium plasma sprayed surfaces indicates a strong interlock and finally implant fixation. Our findings indicate a positive impact of the tested surface modifications on osseointegration.

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“…All of these surface modification methods fundamentally aim to control chemical interaction, surface energy, contact angle and contact area between tissue and implant for a good osseointegration. For an acceptable implant procedure an optimum interlocking between the organic tissue and titanium surface has been proposed as an osseointegration by establishing a good contact between bone and Tiimplant [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Measurement and image processing evaluation of surface modifications of dental implants G4 pure titanium created by different techniques

Bulutsuz¹,

Demircioglu²,

Böğrekçi³

et al. 2015

AIP Conference Proceedings

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Abstract. Foreign substances and organic tissue interaction placed into the jaw in order to eliminate tooth loss involves a highly complex process. Many biological reactions take place as well as the biomechanical forces that influence this formation. Osseointegration denotes to the direct structural and functional association between the living bone and the load-bearing artificial implant's surface. Taking into consideration of the requirements in the manufacturing processes of the implants, surface characterizations with high precise measurement techniques are investigated and thus long-term success of dental implant is emphasized on the importance of these processes in this study. In this research, the detailed surface characterization was performed to identify the dependence of the manufacturing techniques on the surface properties by using the image processing methods and using the scanning electron microscope (SEM) for morphological properties in 3D and Taylor Hobson stylus profilometer for roughness properties in 2D. Three implant surfaces fabricated by different manufacturing techniques were inspected, and a machined surface was included into the study as a reference specimen. The results indicated that different surface treatments were strongly influenced surface morphology. Thus 2D and 3D precise inspection techniques were highlighted on the importance for surface characterization. Different image analyses techniques such as Dark-light technique were used to verify the surface measurement results. The computational phase was performed using image processing toolbox in Matlab with precise evaluation of the roughness for the implant surfaces. The relationship between the number of black and white pixels and surface roughness is presented. FFT image processing and analyses results explicitly imply that the technique is useful in the determination of surface roughness. The results showed that the number of black pixels in the image increases with increase in surface roughness.

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In Vitro Investigation of Orthopedic Titanium-Coated and Brushite-Coated Surfaces Using Human Osteoblasts in the Presence of Gentamycin

Cited by 31 publications

References 47 publications

Quaternised chitosan coating on titanium provides a self-protective surface that prevents bacterial colonisation and implant-associated infections

Quaternised chitosan coating on titanium provides a self-protective surface that prevents bacterial colonisation and implant-associated infections

Evaluation of topographical and chemical modified TiAl6V4 implant surfaces in a weight‐bearing intramedullary femur model in rabbit

Measurement and image processing evaluation of surface modifications of dental implants G4 pure titanium created by different techniques

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