In vitro investigation of growth factors including MGF and IGF-1 in neural stem cell activation, proliferation, and migration

Tunç, Burcu Sarya; Toprak, Fatih; Toprak, Selin Fulya; Sözer, Selçuk

doi:10.1016/j.brainres.2021.147366

Cited by 14 publications

(2 citation statements)

References 80 publications

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“…IGF-1Ec is highly force-sensitive [96]. It also functions as a crucial regenerative agent, stimulating the activation of stem cells [97,98].…”

Section: Insulin-like Growth Factor (Igf-1)mentioning

confidence: 99%

Recent Advances in the Use of Stem Cells in Tissue Engineering and Adjunct Therapies for Tendon Reconstruction and Future Perspectives

Dec,

Żyłka,

Burszewski

et al. 2024

IJMS

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Due to their function, tendons are exposed to acute injuries. This type of damage to the musculoskeletal system represents a challenge for clinicians when natural regeneration and treatment methods do not produce the expected results. Currently, treatment is long and associated with long-term complications. In this review, we discuss the use of stem cells in the treatment of tendons, including how to induce appropriate cell differentiation based on gene therapy, growth factors, tissue engineering, proteins involved in regenerative process, drugs and three-dimensional (3D) structures. A multidirectional approach as well as the incorporation of novel components of the therapy will improve the techniques used and benefit patients with tendon injuries in the future.

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“…IGF-1Ec is highly force-sensitive [96]. It also functions as a crucial regenerative agent, stimulating the activation of stem cells [97,98].…”

Section: Insulin-like Growth Factor (Igf-1)mentioning

confidence: 99%

Recent Advances in the Use of Stem Cells in Tissue Engineering and Adjunct Therapies for Tendon Reconstruction and Future Perspectives

Dec,

Żyłka,

Burszewski

et al. 2024

IJMS

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“…Among the molecules released by astrocytes are FGF-2, VEGF, IGF-1, ATP, and D-serine, which are well known to promote NSC proliferation, both in vitro and in vivo [ 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 ]. As part of the neurovascular unit, astrocytes also participate in the activity-dependent uptake of such factors from the blood, as has been shown for IGF-1 [ 135 , 136 ].…”

Section: Neurogenic Nichementioning

confidence: 99%

From Youthful Vigor to Aging Decline: Unravelling the Intrinsic and Extrinsic Determinants of Hippocampal Neural Stem Cell Aging

Jiménez Peinado,

Urbach

2023

Cells

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Since Joseph Altman published his pioneering work demonstrating neurogenesis in the hippocampus of adult rats, the number of publications in this field increased exponentially. Today, we know that the adult hippocampus harbors a pool of adult neural stem cells (NSCs) that are the source of life-long neurogenesis and plasticity. The functions of these NSCs are regulated by extrinsic cues arising from neighboring cells and the systemic environment. However, this tight regulation is subject to imbalance with age, resulting in a decline in adult NSCs and neurogenesis, which contributes to the progressive deterioration of hippocampus-related cognitive functions. Despite extensive investigation, the mechanisms underlying this age-related decline in neurogenesis are only incompletely understood, but appear to include an increase in NSC quiescence, changes in differentiation patterns, and NSC exhaustion. In this review, we summarize recent work that has improved our knowledge of hippocampal NSC aging, focusing on NSC-intrinsic mechanisms as well as cellular and molecular changes in the niche and systemic environment that might be involved in the age-related decline in NSC functions. Additionally, we identify future directions that may advance our understanding of NSC aging and the concomitant loss of hippocampal neurogenesis and plasticity.

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Transplantation of Neural Stem Cells Loaded in an IGF‐1 Bioactive Supramolecular Nanofiber Hydrogel for the Effective Treatment of Spinal Cord Injury

Song,

Han,

et al. 2024

Advanced Science

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Spinal cord injury (SCI) leads to massive cell death, disruption, and demyelination of axons, resulting in permanent motor and sensory dysfunctions. Stem cell transplantation is a promising therapy for SCI. However, owing to the poor microenvironment that develops following SCI, the bioactivities of these grafted stem cells are limited. Cell implantation combined with biomaterial therapies is widely studied for the development of tissue engineering technology. Herein, an insulin‐like growth factor‐1 (IGF‐1)‐bioactive supramolecular nanofiber hydrogel (IGF‐1 gel) is synthesized that can activate IGF‐1 downstream signaling, prevent the apoptosis of neural stem cells (NSCs), improve their proliferation, and induce their differentiation into neurons and oligodendrocytes. Moreover, implantation of NSCs carried out with IGF‐1 gels promotes neurite outgrowth and myelin sheath regeneration at lesion sites following SCI. In addition, IGF‐1 gels can enrich extracellular vesicles (EVs) derived from NSCs or from nerve cells differentiated from these NSCs via miRNAs related to axonal regeneration and remyelination, even in an inflammatory environment. These EVs are taken up by autologous endogenous NSCs and regulate their differentiation. This study provides adequate evidence that combined treatment with NSCs and IGF‐1 gels is a potential therapeutic strategy for treating SCI.

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In vitro investigation of growth factors including MGF and IGF-1 in neural stem cell activation, proliferation, and migration

Cited by 14 publications

References 80 publications

Recent Advances in the Use of Stem Cells in Tissue Engineering and Adjunct Therapies for Tendon Reconstruction and Future Perspectives

Recent Advances in the Use of Stem Cells in Tissue Engineering and Adjunct Therapies for Tendon Reconstruction and Future Perspectives

From Youthful Vigor to Aging Decline: Unravelling the Intrinsic and Extrinsic Determinants of Hippocampal Neural Stem Cell Aging

Transplantation of Neural Stem Cells Loaded in an IGF‐1 Bioactive Supramolecular Nanofiber Hydrogel for the Effective Treatment of Spinal Cord Injury

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