In vitro investigation of estrogenic – antiestrogenicl activity of extracts obtained from Greek Legumes

Tsiapara, Anna; Kassi, Evanthia; Angelis, Apostolis; Aligiannis, Nektarios; Moutsatsou, Paraskevi

doi:10.1055/s-0028-1084343

Cited by 3 publications

(4 citation statements)

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“…Tsiapara, Kassi, Angelis, Aligiannis, and Moutsatsou (2008) recommended a legume‐rich diet to be used for the prevention of breast cancer and osteoporosis. In their work, they examined the estrogenic/antiestrogenic activities of Proteus vulgaris and V. faba (herb) methanol extracts.…”

Section: Pharmacological and Biological Activities Of Vicia Plantsmentioning

confidence: 99%

“…In their work, they examined the estrogenic/antiestrogenic activities of Proteus vulgaris and V. faba (herb) methanol extracts. All methanol extracts exhibited a significant estrogenic effect at concentration 1–100 μg/mL and significantly inhibited E 2 ‐stimulated luciferase gene induction in MCF‐7 cells co‐transfected with an estrogen response element‐driven luciferase reporter gene (Tsiapara et al, 2008).…”

Section: Pharmacological and Biological Activities Of Vicia Plantsmentioning

confidence: 99%

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Vicia plants—A comprehensive review on chemical composition and phytopharmacology

Salehi

Abu‐Reidah

Sharopov

et al. 2020

Phytotherapy Research

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The plants belonging to the genus Vicia are of great interest as a source of many bioactive compounds and micronutrients. A snapshot of their cultivation, habitat, main components, from which essential oils can be obtained, is given. The traditional medicinal uses of Vicia plants are also reported, as well as the wide spectrum of the main biological activities attributed to Vicia plants is discussed regarding potential health beneficial properties, in particular anti‐Parkinson, anticholinesterase, antidepressant, anticonvulsant, antimicrobial, cytotoxic, antioxidant, antiinflammatory and antinociceptive, antidiabetic, antihemolytic, anticoagulant, estrogenic, diuretic, antihypoxic activities.

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Section: Pharmacological and Biological Activities Of Vicia Plantsmentioning

confidence: 99%

Section: Pharmacological and Biological Activities Of Vicia Plantsmentioning

confidence: 99%

Vicia plants—A comprehensive review on chemical composition and phytopharmacology

Salehi

Abu‐Reidah

Sharopov

et al. 2020

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…These naturally occurring sterols bear tremendous similarity to synthetic steroids such as corticosterone and hydrocorticosterone. 3 RCO is derived from the seed of the Ricinus communis plant. Ricinoleic acid accounts for 87-90% of the fatty acyl groups in RCO with oleic acid (2-7%), linoleic acid (3-5%), palmitic acid (1-2%), stearic acid (1%), dihydrostearic acid (1%) and trace amounts of other fatty acyls.…”

Section: Introductionmentioning

confidence: 99%

“…Avocado oil ( Persea gratissima ) contains phytosterols such as β-sitosterol, campsterols, stigmasterols, brasicasterols, tocopherols and other unidentified sterols. These naturally occurring sterols bear tremendous similarity to synthetic steroids such as corticosterone and hydrocorticosterone 3 . RCO is derived from the seed of the Ricinus communis plant.…”

Section: Introductionmentioning

confidence: 99%

Generational reproductive outcomes in Wistar rats maternally exposed to Ricinus communis oil at different stages of gestation

Salami

Raji

2015

J Dev Orig Health Dis

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Fetal programming hypothesis presupposes that stimulus or insult acting during critical periods of uterine growth and development may permanently alter tissue structure and function. Ricinus communis oil (RCO) has been reported to possess/used as laxative, labor-inducing and estrogenic properties. Generational reproductive effects of maternal exposure to RCO was investigated in rats. A total of 25 pregnant rats randomly assigned to five equal groups were treated with distilled water (control, group 1), RCO (950 mg/kg p.o.) during gestation days (GD) 1-7, 7-14, 14-21 and 1-21, respectively. Birth weight, morphometric data, anogenital distance (AGD), pubertal age, sperm parameters, hormonal profile, organ weight and histopathology were determined in the first (F1) and second (F2) filial generations. Results showed a significant decrease (P<0.05) in birth weight/morphometric data in male pups from the GD 1-7 and 7-14 groups. AGD decreased significantly in RCO-treated F1 males. Pubertal age of F1 females decreased significantly (P<0.05) compared with controls. At postnatal day 90, F1 males from the RCO-treated group showed significant decrease in testis weight, body weight, sperm count, motility and normal morphology. Testosterone levels were significantly decreased in RCO-treated F1 males, which also showed testicular interstitial edema and epididymal hypospermia. Only pubertal indexes were altered in F2 rats. Maternal exposure to RCO at early gestation periods impaired androgen-mediated reproductive end points in the first generation of rats. RCO exhibits endocrine disrupting capabilities.

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Faba-Bean Antioxidant and Bioactive Composition: Biochemistry and Functionality

Alam

Najam

2022

Faba Bean: Chemistry, Properties and Functionality

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In vitro investigation of estrogenic – antiestrogenicl activity of extracts obtained from Greek Legumes

Cited by 3 publications

References 0 publications

Vicia plants—A comprehensive review on chemical composition and phytopharmacology

Vicia plants—A comprehensive review on chemical composition and phytopharmacology

Generational reproductive outcomes in Wistar rats maternally exposed to Ricinus communis oil at different stages of gestation

Faba-Bean Antioxidant and Bioactive Composition: Biochemistry and Functionality

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