In vitro investigation of electrophoretically deposited bioactive hydroxyapatite/chitosan coatings reinforced by graphene

Đošić, Marija; Eraković, Sanja; Janković, Ana; Vukašinović-Sekulić, Maja; Matić, Ivana Z.; Stojanović, Jovica; Rhee, Kyong-Yop; Mišković‐Stanković, Vesna; Park, Soo‐Jin

doi:10.1016/j.jiec.2016.12.004

Cited by 50 publications

(54 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…C 2018, 4, x FOR PEER REVIEW 2 of 8 setting adequate parameters [1,2,6,[12][13][14]. The purpose of this present study is to demonstrate the effect of current density on thickness, morphology, microtexture, and chemical composition of the CaP phases deposited on carbon cloths in order to modulate these features according to desired application.…”

Section: Characteristics Of Carbon Fiber Scaffoldmentioning

confidence: 99%

Development and Characterization of Biomimetic Carbonated Calcium-Deficient Hydroxyapatite Deposited on Carbon Fiber Scaffold

Picard

Olivier

Delpeux

et al. 2018

View full text Add to dashboard Cite

Calcium phosphate and derivatives have been known for decades as bone compatible biomaterials. In this work, the chemical composition, microtexture, and structure of calcium phosphate deposits on carbon cloths were investigated. Three main types of deposits, obtained through variation of current density in using the sono-electrodeposition technique, were elaborated. At low current densities, the deposit consists in a biomimetic, plate-like, carbonated calcium-deficient hydroxyapatite (CDA), likely resulting from the in situ hydrolysis of plate-like octacalcium phosphate (OCP), while at higher current densities the synthesis leads to a needle-like carbonated CDA. At intermediate current densities, a mixture of plate-like and needle-like carbonated CDA is deposited. This established that sono-electrodeposition is a versatile process that allows the coating of the carbon scaffold with biomimetic calcium phosphate while tuning the morphology and chemical composition of the deposited particles, thereby bringing new insights in the development of new biomaterials for bone repair.

show abstract

Section: Characteristics Of Carbon Fiber Scaffoldmentioning

confidence: 99%

Development and Characterization of Biomimetic Carbonated Calcium-Deficient Hydroxyapatite Deposited on Carbon Fiber Scaffold

Picard

Olivier

Delpeux

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Therefore, examination of the properties of biomaterials is among the most important medical challenges. In particular, materials used as implants must have biocompatibility properties [1,2]. Among the biomaterials known so far, HA and its composites have received much attention and among the HA composites, nanocomposites using carbon materials have shown more interesting properties.…”

Section: Introductionmentioning

confidence: 99%

Investigating the mechanical behavior of hydroxyapatite-reduced graphene oxide nanocomposite under different loading rates

Nosrati

Sarraf-Mamoory

et al. 2020

Nano Ex.

View full text Add to dashboard Cite

In this study, the hydroxyapatite (HA)-reduced graphene oxide (rGO) nanocomposite was investigated for its mechanical properties. The nanocomposite used in this study was made in two stages. The HA-rGO powders were first synthesized by hydrogen gas injected hydrothermal method, and then consolidated by spark plasma sintering. HA-rGO nanocomposite was subjected to Vickers indentation experiments with different loading rates. Various analyzes have been used in this study, including x-rays diffraction, field emission scanning electron microscopy, high-resolution transmission electron microscopy, fast fourier transform, and inverse fast fourier transform. The findings of this study showed that the HA in this nanocomposite was reinforced with rGO sheets coated with HA. As the loading rate increased, the slope of the curves in the elastic region was increased, indicating that the elastic modulus was increased. Also, the contact depth at higher loading rates was increased. Plastic deformation was higher at higher loading rates and the hardness had increased. As the loading rate increased from 300 mN to 1 N, the hardness and elastic modulus increased with more slope than when the loading rate changed from 1 N to 2 N. The presence of rGO sheets had partially controlled the HA brittleness.

show abstract

“…10 On the other side, the HAP brittleness and pure mechanical properties have imposed a need for the development of HAP coatings on an appropriate substrate that could provide mechanical support. 11 Commercially pure Ti and its alloys (e.g., Ti4V6Al) have proved as favorable bioinert bone implant materials. 12 Although Ti itself does not possess osteopromotive properties, it is characterized by high corrosion resistance in physiological medium, excellent mechanical properties and biocompatibility with bone tissue (low allergenic effect and inflammation reaction).…”

mentioning

confidence: 99%

“…13 In order to avoid bone implant rejection, it is desirable to design bone implants in such a manner as to replicate the natural bone composition (HAP and collagen). Various natural polymers were investigated for this purpose, in order to enhance adhesion and antibacterial properties of HAP-based composites on titanium, including chitosan, 11 gelatin, 14 collagen, 15 alginate, 16,17 hyaluronic acid 18 and silk fibroin. 19 Among them, chitosan (CS) has attracted the greatest attention due to unique cationic nature associated with its intrinsic antibacterial properties 20 and film-forming ability.…”

mentioning

confidence: 99%

“…21 The load-bearing capacity of HAP/polymer composites can be enhanced by introducing graphene (Gr) as nanofiller. 11 Graphene is a two-dimensional structure composed of single layer sp 2 -hybridized carbon atoms, possessing unique properties such as high specific area, excellent thermal and mechanical characteristics and favorable electrical conductivity, that can affect the features of the host material. 22 Some recent findings have also pointed to the graphene role in biomineralization and implant integration process, 23,24 as well as improved antibacterial activity of composites upon its addition.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Electrophoretically deposited hydroxyapatite-based composite coatings loaded with silver and gentamicin as antibacterial agents

Stevanović

Djošić

Janković

et al. 2019

JSCS

View full text Add to dashboard Cite

Increasing need for improved, compatible bone tissue implants led to the intensive research of novel biomaterials, especially hydroxyapatite (HAP)--based composite materials on titanium and titanium alloy surfaces. Owing to its excellent biocompatibility and osteoinductivity properties, hydroxyapatite is often used as part of composite biomaterials aimed for orthopedic implant applications. In order to overcome persistent problems of bacterial infection, various antimicrobial agents and materials and their incorporation in such medical devices were investigated. This paper represents a comprehensive review of single-step electrodeposition on titanium of hydroxyapatite/chitosan/graphene composite coatings loaded with silver and antibiotic gentamicin as antibacterial agents. The improvement of mechanical and adhesive properties of deposited composite coatings was achieved by graphene and chitosan addition, while desirable antibacterial properties were introduced by including antibiotic gentamicin and silver. The biocompatibility of electrodeposited HAP and HAP-based composite coatings was evaluated by MTT testing, indicating a non-cytotoxic effect and high potential for future medical use as orthopedic implant coating.

show abstract

In vitro investigation of electrophoretically deposited bioactive hydroxyapatite/chitosan coatings reinforced by graphene

Cited by 50 publications

References 58 publications

Development and Characterization of Biomimetic Carbonated Calcium-Deficient Hydroxyapatite Deposited on Carbon Fiber Scaffold

Development and Characterization of Biomimetic Carbonated Calcium-Deficient Hydroxyapatite Deposited on Carbon Fiber Scaffold

Investigating the mechanical behavior of hydroxyapatite-reduced graphene oxide nanocomposite under different loading rates

Electrophoretically deposited hydroxyapatite-based composite coatings loaded with silver and gentamicin as antibacterial agents

Contact Info

Product

Resources

About