In vitro investigation of chemical properties and biocompatibility of neurovascular braided implants

Cattaneo, Giorgio; Bräuner, Chris; Siekmeyer, Gerd; Ding, Andreas; Bauer, Sabina; Wohlschlögel, M.; Lang, Lisa A.; Hierlemann, Teresa; Akimov, Maria; Schlensak, Christian; Schüßler, A.; Wendel, Hans-Peter; Krajewski, Stefanie

doi:10.1007/s10856-019-6270-6

Cited by 14 publications

(7 citation statements)

References 58 publications

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“…Fibroblasts on the other hand can attach and survive on a nitinol surface, but do not grow into a monolayer. These results are in agreement with previous studies showing that endothelial cells, as well as osteoblasts, are able to grow on nitinol surfaces, and that surface properties and the type of proteins adhered to the nitinol surface are important factors determining how well cells grow onto nitinol surfaces [ 24 , 25 ].…”

Section: Discussionsupporting

confidence: 93%

Host–device interactions: exposure of lung epithelial cells and fibroblasts to nickel, titanium, or nitinol affect proliferation, reactive oxygen species production, and cellular signaling

Pouwels

Sigaeva

Boer

et al. 2023

J Mater Sci: Mater Med

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Endoscopic implantation of medical devices for the treatment of lung diseases, including airway stents, unidirectional valves and coils, is readily used to treat central airway disease and emphysema. However, granulation and fibrotic tissue formation impairs treatment effectiveness. To date little is known about the interaction between implanted devices, often made from metals, such as nickel, titanium or nitinol, and cells in the airways. Here, we study the response of lung epithelial cells and fibroblasts to implant device materials. The adhesion and proliferation of bronchial epithelial cells and lung fibroblasts upon exposure to 10 × 3 × 1 mm pieces of nickel, titanium or nitinol is examined using light and scanning electron microscopy. Pro-inflammatory cytokine mRNA expression and release, signaling kinase activity and intracellular free radical production are assessed. Nitinol, and to a lesser extent nickel and titanium, surfaces support the attachment and growth of lung epithelial cells. Nitinol induces a rapid and significant alteration of kinase activity. Cells directly exposed to nickel or titanium produce free radicals, but those exposed to nitinol do not. The response of lung epithelial cells and fibroblasts depends on the metal type to which they are exposed. Nitinol induces cellular surface growth and the induction of kinase activity, while exposure of lung epithelial cells to nickel and titanium induces free radical production, but nitinol does not. Graphical Abstract

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Section: Discussionsupporting

confidence: 93%

Host–device interactions: exposure of lung epithelial cells and fibroblasts to nickel, titanium, or nitinol affect proliferation, reactive oxygen species production, and cellular signaling

Pouwels

Sigaeva

Boer

et al. 2023

J Mater Sci: Mater Med

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“…However, it has been reported that procedures such as electropolishing, passivation in boiling water, and carbon layer deposition improved resistance to crevice corrosion [15], and, after chemical polishing, there is still a high Ni concentration on the surface of nitinol alloy [16]. On the other hand, it has been reported that electropolishing can form a Ni-deficient thin (about 10 nm) surface titanium oxide film and more effectively mitigates the outward diffusion of Ni ions, improving wettability, blood compatibility, and thrombus resistance [17].…”

Section: Introductionmentioning

confidence: 99%

Salt Heat Treatment and Passivation to Improve the Corrosion Resistance of Nitinol (Ni-Ti)

Bae

Kim

et al. 2021

Materials

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Corrosion of nitinol (NiTi) is a major factor in the failure of implantable materials. Recently, as the importance of corrosion of metals has increased, testing according to international guidelines is essential. The purpose of this study was to evaluate the corrosion resistance of NiTi wire through heat treatment and passivation process. In this study, NiTi wire used two commercially available products and a self-manufactured stent. Experimental consideration was carried out according to ASTM standards. Heat treatment was carried out in an air or a salt furnace, and the corrosion was measured after additional process, such as passivation and scratch tests. As a result, the metal potential was rapidly decreased in the air furnace group. On the other hand, the potential of wires was dramatically increased in the salt furnace group compared to the air furnace group. The dislocation decreased below the acceptance criteria (>600 mV) within 60 s of heat treatment time in the air furnace. Moreover, the potential was dramatically improved, even after only 20 min of passivation treatment (1076 mV, 442% compared to the non-passivated group), and it continued to rise until 180 min. This phenomenon was similarly observed in the group of self-manufactured stents. The potential slightly decreased by the scratch process (93.1%) was significantly reduced by the air furnace process (315 mV, 24.4% of the nontreated group). In the passivated group of the air furnace sample with reduced potential, the potential was restored to the level before the air furnace (scratch stage) (1032 mV). In conclusion, the heat treatment is preferably carried out in a salt furnace rather than an air furnace, and the passivation process can be an advantageous tool to improve corrosion resistance by suppressing the oxidation process.

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“…The results, including viability assay, SEM and confocal microscopy, indicate that the coating is slightly though not-significant superior in term of endothelial cell proliferation then the bare electropolished surface of the Nitinol implant, whose good cell compatibility was proved in a previous study [50].…”

Section: Discussionmentioning

confidence: 64%

In vitro investigation of an intracranial flow diverter with a fibrin-based, hemostasis mimicking, nanocoating

Link¹,

Michel

Schaller

et al. 2020

Biomed. Mater.

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Flow diversion aims at treatment of intracranial aneurysms via vessel remodeling mechanisms, avoiding the implantation of foreign materials into the aneurysm sack. However, complex implantation procedure, high metal surface and hemodynamic disturbance still pose a risk for thromboembolic complications in the clinical praxis. A novel fibrin and heparin based nano coating considered as a hemocompatible scaffold for neointimal formation was investigated regarding thrombogenicity and endothelialization. The fibrin-heparin coating was compared to a bare metal as well as fibrin- or heparin-coated flow diverters. The implants were tested separately in regard to inflammation and coagulation markers in two different in vitro hemocompatibility models conducted with human whole blood (n = 5). Endothelialization was investigated through a novel dynamic in vitro cell seeding model containing primary human cells with subsequent viability assay. It was demonstrated that platelet loss and platelet activation triggered by presence of a bare metal stent could be significantly reduced by applying the fibrin-heparin, fibrin and heparin coating. Viability of endothelial cells after proliferation was similar in fibrin-heparin compared to bare metal implants, with a slight, non-significant improvement observed in the fibrin-heparin group. The results suggest that the presented nanocoating has the potential to reduce thromboembolic complications in a clinical setting. Though the new model allowed for endothelial cell proliferation under flow conditions, a higher number of samples is required to assess a possible effect of the coating.

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In vitro investigation of chemical properties and biocompatibility of neurovascular braided implants

Cited by 14 publications

References 58 publications

Host–device interactions: exposure of lung epithelial cells and fibroblasts to nickel, titanium, or nitinol affect proliferation, reactive oxygen species production, and cellular signaling

Host–device interactions: exposure of lung epithelial cells and fibroblasts to nickel, titanium, or nitinol affect proliferation, reactive oxygen species production, and cellular signaling

Salt Heat Treatment and Passivation to Improve the Corrosion Resistance of Nitinol (Ni-Ti)

In vitro investigation of an intracranial flow diverter with a fibrin-based, hemostasis mimicking, nanocoating

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