In vitro Interactions between Bovine Papillomavirus and Human Monocytes and Macrophages

Bonnez, William; Reichman, Richard C.; Strussenberg, Joanne; Roberts, Norbert J.

doi:10.1159/000150206

Cited by 6 publications

(3 citation statements)

References 9 publications

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“…HPV particles with oncoproteins E6 and E7 could, theoretically, be transferred to atherosclerotic plaques through monocytes and macrophages recruited to HPV-infected tissue [13,28,29,30,31]. A recent study showed the presence of HR-HPV DNA in 55% of atheromatous coronary arteries collected from 20 patients deceased due to myocardial infarction [12].…”

Section: Cardiovascular Disease Associated With Hpv Infectionmentioning

confidence: 99%

Novel Biomarkers of Early Atherosclerotic Changes for Personalised Prevention of Cardiovascular Disease in Cervical Cancer and Human Papillomavirus Infection

Tonhajzerová

Olexova

Jurko

et al. 2019

IJMS

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Cervical cancer is associated with a causative role of human papillomavirus (HPV), which is a highly prevalent infection. Recently, women with a genital HPV infection were found to have increased incidence of cardiovascular diseases (CVD), including severe cardiovascular events such as myocardial infarction and stroke. The pathomechanisms of this relation are not yet fully understood, and may significantly affect the health of a large part of the population. Accelerated atherosclerosis is assumed to play a key role in the pathophysiology of this relationship. To identify high-risk groups of the population, it is necessary to stratify the CVD risk. Current algorithms, as widely used for the estimation of CVD risk, seem to be limited by the individual misclassification of high-risk subjects. However, personalised prediction of cardiovascular events is missing. Regarding HPV-related CVD, identification of novel sensitive biomarkers reflecting early atherosclerotic changes could be of major importance for such personalised cardiovascular risk prediction. Therefore, this review focuses on the pathomechanisms leading to HPV-related cardiovascular diseases with respect to atherosclerosis, and the description of potential novel biomarkers to detect the earliest atherosclerotic changes important for the prevention of CVD in HPV infection and cervical cancer.

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Section: Cardiovascular Disease Associated With Hpv Infectionmentioning

confidence: 99%

Novel Biomarkers of Early Atherosclerotic Changes for Personalised Prevention of Cardiovascular Disease in Cervical Cancer and Human Papillomavirus Infection

Tonhajzerová

Olexova

Jurko

et al. 2019

IJMS

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“…Previous studies have shown that DCs express the α6 integrin receptor, which is associated with viral entry (18,19). Additionally, human monocytes and macrophages are known to be susceptible to bovine papillomavirus infection in vitro (20).…”

Section: Introductionmentioning

confidence: 99%

Human dendritic cells transfected with a human papilloma virus-18 construct display decreased mobility and upregulated cytokine production

Khaiboullina

Morzunov

Hall

et al. 2013

International Journal of Oncology

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Abstract. The marked depletion of dendritic cells (DCs) in skin cancers, as well as preneoplastic and neoplastic cervical epithelium, suggests a central role for DCs in productive human papillomavirus (HPV) infection and cancer promotion. It has been suggested that HPV may facilitate tumor development by reducing DC density, contributing to a decrease in local immune surveillance. In this study, we have examined the response of human DCs transfected with a construct containing the HPV18 genome and their subsequent expression of papilloma virus proteins. Transfected cells expressed the L1 major capsid protein and upregulated E6 and E7 oncoprotein transcripts as detected by RT-PCR. Transfection of DCs also resulted in a significant increase in cytokine production. Finally, we observed that HPV18 transfection decreased the migratory activity of DCs. Our data indicate that HPV transfection of DCs leads to changes in migratory activity and cytokine production, which potentially can suppress or delay immune responses to viral antigens. Additionally, changes in cytokine production by HPV-transformed human fibroblasts and human cervical epithelial cells revealed that the migratory and antigen-presenting functions of DCs may be impaired by the suppressive effects of cytokines produced by HPV-infected epithelial and stromal cells.

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“…However, these findings remain contro versial because some groups have not identified HPV in lymphocytes of patients with cervical intraepithelial neo plasia [8]. Finally, Campo et al [2] identified bovine pap illomavirus in PBLs of cows and suggested that these cells may be another site for viral latency, while another group demonstrated the presence of bovine papillomavirus cap sid proteins in experimentally infected monocytes and macrophages [1].…”

mentioning

confidence: 99%

Human Papillomavirus Is Associated with Monoclonal Gammopathies of Unknown Significance

Payne¹,

Chan²,

Schoaib³

et al. 1996

J Biomed Sci

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When monoclonal gammopathies arise in persons without evidence of plasma cell malignancy or lymphoproliférative disease, the term ‘monoclonal gammopathy of unknown significance’ (MGUS) can be used. MGUS is believed to be the preneoplastic phase of lymphoproliférative diseases because many of these patients eventually develop malignant disease, mainly multiple myeloma. We have previously identified human papillomavirus (HPV) in a chronic benign plasma cell tumor of the cervix and in the bone marrow of multiplemyeloma patients. In the following study, we expanded upon our initial observation by analyzing 14 patients with MGUS. Bone marrow biopsies of the patients were analyzed for HPV sequences using polymerase chain reaction (PCR) and in situ hybridization. Normal controls included 26 bone marrow specimens, 24 analyzed by PCR and two by in situ hybridization. A significant association was found to exist between HPV and MGUS (p = 0.001). Among 14 patients with MGUS, HPV sequences have been identified in 10 of the bone marrow biopsies. These results suggest that HPV can reside in the bone marrow of a premalignant lymphoproliférative disease.

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In vitro Interactions between Bovine Papillomavirus and Human Monocytes and Macrophages

Cited by 6 publications

References 9 publications

Novel Biomarkers of Early Atherosclerotic Changes for Personalised Prevention of Cardiovascular Disease in Cervical Cancer and Human Papillomavirus Infection

Novel Biomarkers of Early Atherosclerotic Changes for Personalised Prevention of Cardiovascular Disease in Cervical Cancer and Human Papillomavirus Infection

Human dendritic cells transfected with a human papilloma virus-18 construct display decreased mobility and upregulated cytokine production

Human Papillomavirus Is Associated with Monoclonal Gammopathies of Unknown Significance

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