In Vitro Insights Into the Influence of Marrow Mesodermal/Mesenchymal Progenitor Cells on Acute Myelogenous Leukemia and Myelodysplastic Syndromes

Abstract

The study of marrow-resident mesodermal progenitors can provide important insight into their role in influencing normal and aberrant hematopoiesis as occurs in acute myelogenous leukemia (AML) and myelodysplastic syndromes (MDS). In addition, the chemokine competency of these cells provides links to the inflammatory milieu of the marrow microenvironment with additional implications for normal and malignant hematopoiesis. While in vivo studies have elucidated structure and function of the marrow niche in murine genetic models, corollary human studies have not been feasible, and thus use of culture adapted mesodermal cells has provided insights into the role these rare endogenous niche cells play in physiologic, malignant, and inflammatory states. This review focuses on culture adapted human mesenchymal stem/stromal cells (MSCs) as they have been utilized in understanding their influence in AML and MDS as well as on their chemokine—mediated responses to myeloid malignancies, injury, and inflammation. Such studies have intrinsic limitations but have provided mechanistic insights and clues regarding novel druggable targets.

Unveiling the Role of Endometrial CD-138: A Comprehensive Review on Its Significance in Infertility and Early Pregnancy

“…In the pursuit of comprehending neuronal regeneration and repair, in vitro studies focusing on stem cells and their interactions with the extracellular matrix provide valuable insights into the potential for addressing neurological disorders [ 26 ]. Similarly, investigations into immune system function, involving in vitro studies on immune cells and their interactions with various cell types, assist researchers in understanding the immune response and developing therapies for autoimmune and immune-related disorders [ 27 ].…”