In-vitro inhibitory effects of flavonoids in Rosa roxburghii and R. sterilis fruits on α-glucosidase: Effect of stomach digestion on flavonoids alone and in combination with acarbose

Zhu, Jian; Zhang, Bin; Wang, Bingxu; Li, Chao; Fu, Xiong; Huang, Qiang

doi:10.1016/j.jff.2019.01.009

Cited by 31 publications

(20 citation statements)

References 32 publications

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“…Rosa roxburghii fruit have also been reported to exert antioxidant, antiatherogenic, antimutagenic, and radioprotective activities (He et al., 2016; Westhuizen et al., 2008; Xu et al., 2016). The health benefits have been attributed to the bioactive components including flavonoids, organic acids, triterpenes, and polysaccharides present in the R. roxburghii fruit (Liu et al., 2016; Xu et al., 2017; Zhu et al., 2019). The contents of total phenolics, total flavonoids, and ascorbic acid in R. roxburghii fruit were much higher than the selected fruits and vegetables, such as strawberry, blueberry, and lemon (Yang et al., 2020).…”

Section: Introductionmentioning

confidence: 99%

Thermally induced isomerization of linoleic acid and α‐linolenic acid in Rosa roxburghii Tratt seed oil

Luo

et al. 2021

Food Science & Nutrition

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Rosa roxburghii seed oil is obtained from the seeds left following pressing of the juice from R. roxburghii fruit. The total oil content of R. roxburghii seed was around 9.30%. The fatty acid profile of the oil was determined by gas chromatography (GC). Among the 11 fatty acids identified in the oil, seven were unsaturated fatty acids (UFAs) (92.6%); four were saturated fatty acids (SFAs) (7.17%). Then, the kinetics of formation of trans‐fatty acids was studied by GC. Heat treatment of R. roxburghii seed oil showed an increase in the relative percentage of linoleic acid and α‐linolenic acid isomers with increasing temperature and time. The formation of linoleic acid and α‐linolenic acid isomers followed a zero‐order reaction. The presence of O2 enhanced the isomerization of these UFAs. In addition, the rate constants and activation energies for the geometrical isomerization of UFAs in R. roxburghii seed oil were presented. Overall, R. roxburghii seed oil contains high UFA contents. Heating temperature and duration and the presence of O2 should be considered to reduce the formation of trans‐fatty acids during thermal treatment of R. roxburghii seed oil.

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Section: Introductionmentioning

confidence: 99%

Thermally induced isomerization of linoleic acid and α‐linolenic acid in Rosa roxburghii Tratt seed oil

Luo

et al. 2021

Food Science & Nutrition

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“…Besides that, rutin, kaempferol hexose, and catechin were the most abundant flavonoids found in the extraction of R. roxburghii fruits dispersion. Among these components, catechin showed the greatest inhibitory effects on α -glucosidase with the highest IC 50 value [ 33 ].…”

Section: Flavonoidsmentioning

confidence: 99%

Hypoglycemic Effects of Plant Flavonoids: A Review

Yen

Qin

Xuan

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Diabetes mellitus is a metabolic disorder with chronic high blood glucose levels, and it is associated with defects in insulin secretion, insulin resistance, or both. It is also a major public issue, affecting the world's population. This disease contributes to long-term health complications such as dysfunction and failure of multiple organs, including nerves, heart, blood vessels, kidneys, and eyes. Flavonoids are phenolic compounds found in nature and usually present as secondary metabolites in plants, vegetables, and fungi. Flavonoids possess many health benefits such as anti-inflammatory and antioxidant activities, and naturally occurring flavonoids contribute to antidiabetic effects.Many studies conducted in vivo and in vitro have proven the hypoglycemic effect of plant flavonoids. A large number of studies showed that flavonoids hold positive results in controlling the blood glucose level in streptozotocin (STZ)-induced diabetic rats and further prevent the complications of diabetes. The future development of flavonoid-based drugs is believed to provide significant effects on diabetes mellitus and diabetes complication diseases. This review aims at summarizing the various types of flavonoids that function as hyperglycemia regulators such as inhibitors of α-glucosidase and glucose cotransporters in the body. This review article discusses the hypoglycemic effects of selected plant flavonoids namely quercetin, kaempferol, rutin, naringenin, fisetin, and morin. Four search engines, PubMed, Google Scholar, Scopus, and SciFinder, are used to collect the data.

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“…The lowest content and diversity of phenolics were in the fruits. This can influence the bioactivity of R. acicularis extracts as possible inhibitors of digestive enzymes, because variation in the activity of different phenolic groups is known [71,72], as well as the influence of different Rosa extracts, based on the α-glucosidase, such as R. damascena flowers [73], R. canina fruits [74], R. roxburghii and R. sterilis fruits [75] and R. acicularis leaves [23], and on the amylase, such as R. canina fruits and flowers [76]. In that regard, it is reasonable to study the interaction with digestive enzymes of extracts from R. acicularis organs and define the inhibiting principles of the most active extract.…”

Section: Fruitsmentioning

confidence: 99%

“…Among flora, plants of the Rose genus are famous antidiabetic medicines with an inhibitory influence on digestive enzymes (α-glucosidase, The plant-supporting therapy of diabetes is commonly based on ethnopharmacological data of the application of some extracts, such as hypoglycaemic remedies in traditional medicines [79][80][81]. Among flora, plants of the Rose genus are famous antidiabetic medicines with an inhibitory influence on digestive enzymes (α-glucosidase, α-amylase), including R. canina [74,78], R. damascena [73], R. gallica [78], R. roxburghii and R. sterilis [75]. The prickly rose (Rosa acicularis) is no exception, and is used in Tibetan and Siberian traditional medicines to prepare antidiabetic decoctions, extracts and tablets [12,13], although it is still an underestimated plant with poor scientific knowledge in regard to its metabolites and bioactivity.…”

Section: Digestive-enzyme-inhibiting Potential Of R Acicularis Extracts and Rugosin Dmentioning

confidence: 99%

Metabolites of Prickly Rose: Chemodiversity and Digestive-Enzyme-Inhibiting Potential of Rosa acicularis and the Main Ellagitannin Rugosin D

Оленников

Chemposov

Чирикова

2021

Plants

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Prickly rose (Rosaacicularis Lindl.) is the most distributed rose species in the Northern Hemisphere, used by indigenous people for various food purposes. The lack of detailed information about the chemical composition of R. acicularis has led us to study the phytochemical composition and metabolic profile of prickly rose extracts using chromatographic techniques. Many groups of phenolic and non-phenolic compounds were quantified in the leaves, flowers, roots and fruits of R. acicularis. Phenolic compounds were the dominant phytochemicals in the aerial parts and roots of R. acicularis. A precise study by high-performance liquid chromatography with photodiode array detection and electrospray ionization triple quadrupole mass spectrometric detection showed the presence of 123 compounds, among which ellagic acid derivatives, ellagitannins, gallotannins, catechins, catechin oligomers, hydroxycinnamates and flavonoid glycosides of kaempferol, quercetin and dihydroquercetin were all identified for the first time. The most abundant phenolic compounds were ellagitannins and flavonoid glycosides, with a maximal content of 70.04 mg/g in leaves and 66.72 mg/g in flowers, respectively, indicating the great ability of R. acicularis organs to accumulate phenolic compounds. By applying a standardized static, simulated gastrointestinal digestion method, we found the inhibitory potential of the leaf extract against digestive α-amylases. A pancreatic α-amylase activity-inhibiting assay coupled with HPLC microfractionation demonstrated high inhibition of enzyme activity by ellagitannin rugosin D, which was later confirmed by a microplate reaction with mammalian α-amylases and the simulated digestion method. This study clearly demonstrates that R. acicularis leaf extract and its main component, ellagitannin rugosin D, strongly inhibit digestive α-amylase, and may be a prospective antidiabetic agent.

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In-vitro inhibitory effects of flavonoids in Rosa roxburghii and R. sterilis fruits on α-glucosidase: Effect of stomach digestion on flavonoids alone and in combination with acarbose

Cited by 31 publications

References 32 publications

Thermally induced isomerization of linoleic acid and α‐linolenic acid in Rosa roxburghii Tratt seed oil

Thermally induced isomerization of linoleic acid and α‐linolenic acid in Rosa roxburghii Tratt seed oil

Hypoglycemic Effects of Plant Flavonoids: A Review

Metabolites of Prickly Rose: Chemodiversity and Digestive-Enzyme-Inhibiting Potential of Rosa acicularis and the Main Ellagitannin Rugosin D

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