In vitro inhibition of lysine decarboxylase activity by organophosphate esters

Wang, Sufang; Wan, Bin; Zhang, Lianying; Yang, Yu; Guo, Liang-Hong

doi:10.1016/j.bcp.2014.09.011

Cited by 19 publications

(11 citation statements)

References 41 publications

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“…Cucurbiturils have been employed for the detection of biologically relevant molecules, including the detection of cadaverine, a naturally occurring toxic diamine, by Wang et al In this system, the addition of cadaverine to a highly fluorescent supramolecular complex of CB7 with Acridine Orange led to the displacement of the dye and a subsequent decrease in fluorescence. The activity of lysine decarboxylase, which converts lysine into cadaverine, was monitored by observing the differential fluorescence responses of the enzymatic reactant and its product.…”

Section: Luminescent Macrocycle Sensorsmentioning

confidence: 99%

Supramolecular Luminescent Sensors

2018

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There is great need for stand-alone luminescence-based chemosensors that exemplify selectivity, sensitivity, and applicability and that overcome the challenges that arise from complex, real-world media. Discussed herein are recent developments toward these goals in the field of supramolecular luminescent chemosensors, including macrocycles, polymers, and nanomaterials. Specific focus is placed on the development of new macrocycle hosts since 2010, coupled with considerations of the underlying principles of supramolecular chemistry as well as analytes of interest and common luminophores. State-of-the-art developments in the fields of polymer and nanomaterial sensors are also examined, and some remaining unsolved challenges in the area of chemosensors are discussed. CONTENTS 4.4. Explosives 4.5. Pharmaceutical Agents 4.6. Biologically Relevant 4.6.1. Adenosine Triphosphate (ATP)

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Section: Luminescent Macrocycle Sensorsmentioning

confidence: 99%

Supramolecular Luminescent Sensors

2018

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“…An established inhibitor phosphoramidon was adopted to verify the protease inhibition quantifying the capacity of the proposed F-IDA strategy. Wang et al (2014) employed another label-free competitive fluorescence displacement system comprising the macrocyclic host CB7, and AO was employed for the detection of cadaverine. Following the incorporation of the cadaverine into a strongly fluorescent supramolecular CB7-AO complex, the dye was displaced, and the fluorescence was attenuated.…”

Section: Figurementioning

confidence: 99%

Cucurbit[n]uril-based fluorescent indicator-displacement assays for sensing organic compounds

et al. 2023

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The widespread conversion of synthetic receptors into luminescent sensors has been achieved via the use of fluorescent-indicator displacement assays (F-IDAs). Due to their rigid structures and efficient binding affinities, cucurbit[n]urils, combined with a variety of fluorescent guests, have gained extensive utilization in fluorescent-indicator displacement assays for sensing non-fluorescent or weakly fluorescent organic compounds (analytes) in a selective and specific manner. This mini-review summarizes recent advances in the design of cucurbit[n]uril-based fluorescent-indicator displacement assays and discusses the current challenges and future prospects in this area.

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“…Toxicity of OPFRs were closely related to substituent groups. Compared with alkyl group substituted OPFRs, the OPFRs substituted with aromatic or chlorinated alkyl groups could inhibit O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) (Gu et al, 2018) and lysine decarboxylase (LDC) (Wang et al, 2014) activity significantly. The biotransformation of OPFRs substituted with chlorinated alkyl or aromatic chains could more significantly affect the accumulation than those with alkyl chains based on the physiologically based toxicokinetic (PBTK) model (Wang et al, 2017a).…”

Section: Introductionmentioning

confidence: 99%