In-Vitro Inhibition of Lav/HTLV-Iii Infected Lymphocytes by Dithiocarb and Inosine Pranobex

Pompidou, A; Zagury, Daniel; Gallo, RobertC.; Sun, Daisy; Thornton, Andrea A.; Sarin, P. S.

doi:10.1016/s0140-6736(85)92585-1

Cited by 33 publications

(10 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…AZT and isoprinosine alone (up to 100 and 640 ,uM, respectively) and isoprinosine in combination with AZT did not affect the growth of uninfected PBMC (Table 2). DISCUSSION Pompidou and co-workers (18) recently showed that isoprinosine at 200 ,ug/ml, or about 180 ,uM, produced a 48% inhibition of virus replication as measured by an RTA on supernatant obtained from isoprinosine-treated PBMC. However, in H9 cells, isoprinosine had no effect on virus replication (18).…”

mentioning

confidence: 88%

“…DISCUSSION Pompidou and co-workers (18) recently showed that isoprinosine at 200 ,ug/ml, or about 180 ,uM, produced a 48% inhibition of virus replication as measured by an RTA on supernatant obtained from isoprinosine-treated PBMC. However, in H9 cells, isoprinosine had no effect on virus replication (18). In a similar PBMC system, our results with this drug alone were highly variable and complete inhibition of virus yield was not achieved even when isoprinosine was tested at 320 ,uM (357 ,ug/ml).…”

mentioning

confidence: 88%

See 1 more Smart Citation

Combinations of isoprinosine and 3'-azido-3'-deoxythymidine in lymphocytes infected with human immunodeficiency virus type 1

Schinazi

Cannon

Arnold

et al. 1988

Antimicrob Agents Chemother

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 88%

mentioning

confidence: 88%

Combinations of isoprinosine and 3'-azido-3'-deoxythymidine in lymphocytes infected with human immunodeficiency virus type 1

Schinazi

Cannon

Arnold

et al. 1988

Antimicrob Agents Chemother

View full text Add to dashboard Cite

show abstract

“…The discovery of HIV led to a broadening of the view that oxidative stress (OS) may have a principal contribution to both the expression of HIV and development of AIDS [6,7]. Around the same time, empirical observations from unrelated areas of AIDS research appeared to confirm this postulate of an oxidative role [8][9][10]. Studies even began to report the potential use of reducing agents to suppress HIV expression [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Oxidants and Antioxidants in the Pathogenesis of HIV/AIDS

Agarwal¹

2011

TORSJ

View full text Add to dashboard Cite

Human immunodeficiency virus (HIV) has predominantly been considered the main cause in the progression of acquired immunodeficiency syndrome (AIDS). However, many researchers believe that there are co-factors involved along the way that may play a critical role in its development. Elevated levels of reactive oxygen species (ROS) have been established to be present at the onset of infection. Additionally, the delayed response by the immune system upon infection may be due to an initial depletion of antioxidants, which play a critical role in scavenging excess ROS to maintain normal physiological conditions. This pro-oxidant/antioxidant imbalance results in a condition known as oxidative stress (OS). OS has been reported to be an integral element in the progression of many diseases, including AIDS. Therefore, it is presumed that antioxidant treatment may provide a promising and cost-effective therapeutic approach in treating HIV-infected individuals on a global scale.Although HIV infection presents one of the most arduous complications to humans worldwide, awareness of its origin, adverse effects, and potential treatment remain confined to a limited population. The aim of this article is to inform the reader of how AIDS developed into a global epidemic so rapidly, while emphasizing the relationship between oxidants and antioxidants in the pathogenesis of HIV/AIDS. A basic review of reduction/oxidation (redox) reactions is provided to understand how such simple introductory concepts can have such profound effects on the body. This serves as an essential building block to the topics that follow: ROS, antioxidants, and OS in HIV disease. Moreover, it allows for us to better define and elucidate OS as an often-overlooked link between HIV-infection and the progression of AIDS, as well as potential antioxidant treatment.

show abstract

“…LAVgenannt) als der Auslöser der AIDSErkrankung identifiziert worden war, stand als wesentliches Charakteristikum von AIDS ein Defekt in der Zahl der T4 (CD4)-positiven T-Lymphozyten («Helfer/Induktor»-Phäno-typ) fest [1] [4], ist der klinisch wichtigste Effekt die Verstärkung der IL-2-und -y-IFN-Produktion sowie die Induktion von IL-2-Rezeptoren auf Immunzellen [5]. Aktuelle Studien der Gruppe von Fudenberg belegen die …”

Section: Introductionunclassified

Immunstimulation beim Lymphadenopathiesyndrom und bei AIDS -Inosiplex (Inosin pranobex, Methisoprinol)

Großmann

Behrens²

1987

Oncol Res Treat

View full text Add to dashboard Cite

show abstract

In-Vitro Inhibition of Lav/HTLV-Iii Infected Lymphocytes by Dithiocarb and Inosine Pranobex

Cited by 33 publications

References 4 publications

Combinations of isoprinosine and 3'-azido-3'-deoxythymidine in lymphocytes infected with human immunodeficiency virus type 1

Combinations of isoprinosine and 3'-azido-3'-deoxythymidine in lymphocytes infected with human immunodeficiency virus type 1

Oxidants and Antioxidants in the Pathogenesis of HIV/AIDS

Immunstimulation beim Lymphadenopathiesyndrom und bei AIDS -Inosiplex (Inosin pranobex, Methisoprinol)

Contact Info

Product

Resources

About