In vitro inhibition of Chikungunya and Semliki Forest viruses replication by antiviral compounds: synergistic effect of interferon-α and ribavirin combination

Briolant, Sébastien; Garín, Daniel; Scaramozzino, Natale; Jouan, A.; Crance, Jean‐Marc

doi:10.1016/j.antiviral.2003.09.005

Cited by 216 publications

(192 citation statements)

References 37 publications

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“…6 Several chemical compounds have been reported to exhibit weak anti-CHIKV activity. They include apigenin, 6 6-azauridine, 6 chloroquine, 7 chrysin, 6 (5,7-dihydroxy)flavones, 6 interferon, mycophenolic acid, 8 prothipendyl, 6 ribavirin, 9 silibin, 6 etc. In 2011, arbidol and its two derived metabolites were tested in vitro on the CHIKV by use of two cell lines in pre-and post-infection conditions.…”

Section: Introductionmentioning

confidence: 99%

Benzouracil–coumarin–arene conjugates as inhibiting agents for chikungunya virus

et al. 2015

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ABSTRACT. Chikungunya virus (CHIKV) causes an arboviral disease and was first recognized in epidemic form in East Africa in [1952][1953]. The virus is primarily transmitted through mosquitoes and the resulting disease, chikungunya fever, is found in nearly 40 countries.Neither an effective vaccine nor a specific antiviral drug exists for treatments of Chikungunya fever. Thus 25 new triply conjugated compounds of uracil−coumarin−arene were designed and synthesized as potential inhibiting agents. Their chemical structures were determined unambiguously by spectroscopic methods, including single-crystal X-ray diffraction crystallography. The three nuclei in these conjugates were connected by specially designed −SCH2− and −OSO2− joints. Five of these new conjugates were found to inhibit CHIKV Vero 2 cells with significant potency (EC50 = 10.2-19.1 µM) and showed low toxicity (CC50 = 75-178 µM). The selective index values were 9.3-11.5 for three conjugates. By analysis of the data from the anti-viral assays, the structure-activity relationship is derived on the basis of the nature of the uracil nucleus, the joint between the nuclei, and the functional group attached to the arene nucleus.

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Section: Introductionmentioning

confidence: 99%

Benzouracil–coumarin–arene conjugates as inhibiting agents for chikungunya virus

et al. 2015

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“…Une corticothéra-pie peut s'avérer nécessaire dans les formes sévères d'évolution subaiguë-chronique. L'interféron α et la ribavirine auraient une action inhibitrice in vitro, avec effet synergique de l'association [18]. La prévention de cette infection est à la fois collective et individuelle, reposant sur la lutte anti-vectorielle.…”

Section: Les Conséquences De L'infection Chez L'hommeunclassified

Infection par le virus Chikungunya : une alphavirose ré-émergente

2006

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“…Ribavirin (200mg twice per day for seven days) has been shown to be effective for relieving crippling lower limb pains and improved the resolution of these manifestations 45 . The combination of interferon alpha (IFN-α) 2b and ribavirin produces a synergistic anti-CHIKV effect, as demonstrated in an in vitro study 46 . Passive immunization could be an appropriate preventive and therapeutic option for Chikungunya and Mayaro fevers because no alternative therapy is available 47 .…”

Section: Treatment Of Patients and Vaccines To Prevent Chikv And Mayvmentioning

confidence: 99%

Emerging alphaviruses in the Americas: Chikungunya and Mayaro

Figueiredo

2014

Rev. Soc. Bras. Med. Trop.

121

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Chikungunya virus (CHIKV) and Mayaro virus (MAYV) are emergent arthropod-borne viruses that produce outbreaks of acute febrile illness with arthropathy. Despite their different continental origins, CHIKV and MAYV are closely related and are components of the Semliki Forest Complex of the Alphavirus (Togaviridae). MAYV and, more recently, CHIKV, which are both transmitted by Aedes mosquitoes, have resulted in severe public health problems in the Americas, including Brazil. In this review, we present aspects of the pathogenesis, clinical presentation and treatment of febrile illnesses produced by CHIKV and MAYV. We also discuss the epidemiological aspects and effects related to the prophylaxis of infections by both viruses.

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In vitro inhibition of Chikungunya and Semliki Forest viruses replication by antiviral compounds: synergistic effect of interferon-α and ribavirin combination

Cited by 216 publications

References 37 publications

Benzouracil–coumarin–arene conjugates as inhibiting agents for chikungunya virus

Benzouracil–coumarin–arene conjugates as inhibiting agents for chikungunya virus

Infection par le virus Chikungunya : une alphavirose ré-émergente

Emerging alphaviruses in the Americas: Chikungunya and Mayaro

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