In vitro inhibition of adhesion of Escherichia coli strains by Xylitol

Silva, Annelisa Farah da; Suzuki, Érika; Ferreira, Aline Siqueira; Oliveira, Murilo Gomes; Silva, Sílvio Silvério da; Raposo, Nádia Rezende Barbosa

doi:10.1590/s1516-89132011000200003

Cited by 8 publications

(5 citation statements)

References 23 publications

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“…The process exhibited a maximum xylitol extraction efficiency of 40.51% when treated at the highest sample/solvent (11/9) ratio for a minimum extraction time of 20 min. The yield was quite low, but the purity of the obtained xylitol was greater than 89% [87].…”

Section: Biphasic Extractionmentioning

confidence: 93%

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Biological and Pharmacological Potential of Xylitol: A Molecular Insight of Unique Metabolism

Ahuja

Macho

Ewe

et al. 2020

Foods

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Xylitol is a white crystalline, amorphous sugar alcohol and low-calorie sweetener. Xylitol prevents demineralization of teeth and bones, otitis media infection, respiratory tract infections, inflammation and cancer progression. NADPH generated in xylitol metabolism aid in the treatment of glucose-6-phosphate deficiency-associated hemolytic anemia. Moreover, it has a negligible effect on blood glucose and plasma insulin levels due to its unique metabolism. Its diverse applications in pharmaceuticals, cosmetics, food and polymer industries fueled its market growth and made it one of the top 12 bio-products. Recently, xylitol has also been used as a drug carrier due to its high permeability and non-toxic nature. However, it become a challenge to fulfil the rapidly increasing market demand of xylitol. Xylitol is present in fruit and vegetables, but at very low concentrations, which is not adequate to satisfy the consumer demand. With the passage of time, other methods including chemical catalysis, microbial and enzymatic biotransformation, have also been developed for its large-scale production. Nevertheless, large scale production still suffers from high cost of production. In this review, we summarize some alternative approaches and recent advancements that significantly improve the yield and lower the cost of production.

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Section: Biphasic Extractionmentioning

confidence: 93%

“…It was quite effective in curing pneumonia and reducing the mortality rate in neonates [115]. The possible mechanism behind its antiadhesive effect against the otopathogens is its ability to manipulate the structure of bacteria [87] and blocking of bacterial lectins [116].…”

Section: Acute Otitis Mediamentioning

confidence: 99%

Biological and Pharmacological Potential of Xylitol: A Molecular Insight of Unique Metabolism

Ahuja

Macho

Ewe

et al. 2020

Foods

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show abstract

“…Xylitol significantly reduced biofilm formation by 74.22% and 81.03% at 5% and 10% of xylitol, respectively. This may be attributed to the anti-adhesive capability of xylitol [ 49 , 50 , 51 ]. Swarming and swimming were previously linked to microbial cytotoxicity and required for bacterial adherence as the first step of biofilm formation [ 52 , 53 ].…”

Section: Discussionmentioning

confidence: 99%

Xylitol Inhibits Growth and Blocks Virulence in Serratia marcescens

et al. 2021

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Serratia marcescens is an opportunistic nosocomial pathogen and causes wound and burn infections. It shows high resistance to antibiotics and its pathogenicity is mediated by an arsenal of virulence factors. Another therapeutic option to such infections is targeting quorum sensing (QS), which controls the expression of different S. marcescens virulence factors. Prevention of QS can deprive S. marcescens from its bacterial virulence without applying stress on the bacterial growth and facilitates the eradication of the bacteria by immunity. The objective of the current study is to explore the antimicrobial and antivirulence activities of xylitol against S. marcescens. Xylitol could inhibit the growth of S. marcescens. Sub-inhibitory concentrations of xylitol could inhibit biofilm formation, reduce prodigiosin production, and completely block protease activity. Moreover, xylitol decreased swimming motility, swarming motility and increased the sensitivity to hydrogen peroxide. The expression of rsmA, pigP, flhC, flhD fimA, fimC, shlA bsmB, and rssB genes that regulate virulence factor production was significantly downregulated by xylitol. In silico study showed that xylitol could bind with the SmaR receptor by hydrophobic interaction and hydrogen bonding, and interfere with the binding of the natural ligand with SmaR receptor. An in vivo mice survival test confirmed the ability of xylitol to protect mice against the virulence of S. marcescens. In conclusion, xylitol is a growth and virulence inhibitor in S. marcescens and can be employed for the treatment of S. marcescens wound and burn infections.

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“…Söderling and Hietala-Lenkkeri (2010) found that 4% xylitol inhibited six oral streptococci strains adhesion to glass, which indicated that xylitol could contribute to decreased plaque accumulation. Silva et al (2011) found xylitol (0.5, 2.5 and 5.0%) as a sugar inhibitor for the adhesion of two Escherichia coli bacterial strains (ATCC 8739 and clinical enteropathogenic Escherichia coli -EPEC). New products studies, mainly of the biotechnological origin, have been directed in recent years in order to find preventive and corrective strategies for different diseases.…”

Section: Bacterial Adhesionmentioning

confidence: 97%