In vitro induction of tumor-specific immunity. IV. Specific adoptive immunotherapy with cytotoxic T cells induced in vitro to plasmacytoma antigens

Burton, Robert C.; Warner, Noel L.

doi:10.1007/bf00200054

Cited by 33 publications

(13 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since the draining peripheral lymph nodes were found to generate some response late in the course of the development of the tumor, we attempted to devise a means of enhancing the detection of this response at an earlier time. We chose secondary stimulation of in vivo immune lymphoid cells in tissue culture by incubation with mitomycin C-treated or x-irradiated tumor cells (94)(95)(96)(97)(98). Thus, peripheral lymph 125 node cells were removed from tumor-bearing DBA/2 hosts, 14 days after tumor challenge and cultured in vitro with mitomycin C-treated MDAY-D2 tumor cells for a five-day period (93).…”

Section: The Immunogenicity Of Mda Y-d2: Analysis By Ctl Testsmentioning

confidence: 99%

“…MDAY-D2) and in which we use CTLs stimulated against turn-variants to treat established visceral metastases of the parental tumor -as summarized in Figure 11. It is an approach which is essentially a modification of previous attempts at passive CTL therapy, using in vitro sensitized T cells (142)(143)(144)(145)(146), the essential modification being the use of highly immunogenic turn-variants for the stimulation procedures. The rationale was to obtain highly potent cross-reactive (with the parental tumor) T cells which, because they were in culture for only a few days, might survive well and circulate in vivo, (unlike CTLs from long-term interleukin II-dependent cultures which may not survive or recirculate normally in vivo).…”

Section: Adoptive Specific Immunotherapy Of Established Visceral Metamentioning

confidence: 99%

See 1 more Smart Citation

Tumor progression in metastasis: an experimental approach using lectin resistant tumor variants

et al. 1982

View full text Add to dashboard Cite

A novel model of tumor progression in metastatic cancer is described which grew out of attempts to derive stable non-metastatic variants from a highly metastatic mouse tumor called MDAY-D2. The variants were obtained by selection of so-called lectin-resistant (LecR) membrane mutants using toxic concentrations of wheat germ agglutinin (WGA) as the selective agent, after mutagenesis. Cloned WGAR variants almost all appeared to be highly tumorigenic and metastatic, but displayed altered growth properties which were highly suggestive of major cellular phenotypic alterations occurring prior to metastasis. This were confirmed with the discovery that spontaneous visceral metastases always consisted of WGA-sensitive (WGAS) 'revertant' tumor cells. Such revertants also arose at the site of the subcutaneous inoculation and, with time, comprised an increasing proportion of the tumor cells at that location. The WGAS/high metastatic phenotype was stable in vitro or in vivo, implying the WGAR leads to WGAS shift had an underlying genetic basis. Thus, it appeared that the WGAR tumor cells could not metastasize, because of either an intrinsic cellular defect or a host imposed barrier, but that this block could be circumvented through a genetic change in the WGAR tumor cells which was accompanied by reversion of the WGAR phenotype. Non-tumorigenic (tum-) WGAR variants were also obtained, but in these cases the mutagenesis treatment itself appeared responsible for development of the tum- phenotype. The reduced tumorigenicity had an underlying immunological basis, a finding which could be exploited to immunotherapeutically treat established visceral metastases of poorly immunogenic tumors. Throughout these studies, emphasis was placed on the considerable potential of using tumor cell populations having various stable drug-resistant genetic markers to monitor aspects of tumorigenesis, tumor progression, and metastasis.

show abstract

Section: The Immunogenicity Of Mda Y-d2: Analysis By Ctl Testsmentioning

confidence: 99%

Section: Adoptive Specific Immunotherapy Of Established Visceral Metamentioning

confidence: 99%

Tumor progression in metastasis: an experimental approach using lectin resistant tumor variants

et al. 1982

View full text Add to dashboard Cite

show abstract

“…There is adequate evidence (Prowse et al, 1983;Leclerc and Cantor, 1980;Burton and Warner, 1977;Eberlein et al, 1982) that cytolytic T cells are quite capable of passively transferring cell-mediated immunity.…”

Section: Daysmentioning

confidence: 94%

Immunological consequences of tumor excision: From active immunity to immunological memory

Bursuker

North

1986

Intl Journal of Cancer

View full text Add to dashboard Cite

Excision of the immunogenic Meth-A fibrosarcoma during generation by the host of concomitant antitumor immunity resulted in the appearance in sequence of two qualitatively distinct states of post-excision immunity. Immunity expressed on the day of excision was dependent on Ly-1-2+, cyclophosphamide-sensitive T cells, whereas immunity expressed 2 weeks later was dependent on cyclophosphamide-resistant T cells which can be functionally eliminated by either anti-Ly-1 or anti-Ly-2 monoclonal antibody and complement. The data suggest that antitumor immunity expressed shortly after tumor excision represents active concomitant immunity that is acquired by the host before excision is performed. In contrast, immunity expressed 2 weeks later is based on immunological memory.

show abstract

“…However, adoptive immunotherapy of neoplasm in animals and in man with specifically sensitized lymphoid cells has often been shown to be of limited efficacy [1].…”

Section: Introductionmentioning

confidence: 99%

Eradication of tumor cells after injection into immunized hosts compared with the eradication of tumor cells after transfer of immune peritoneal exudates into tumor-bearing recipients

Otter

Groot

Dullens

1983

Cancer Immunol Immunother

View full text Add to dashboard Cite

In vitro induction of tumor-specific immunity. IV. Specific adoptive immunotherapy with cytotoxic T cells induced in vitro to plasmacytoma antigens

Cited by 33 publications

References 34 publications

Tumor progression in metastasis: an experimental approach using lectin resistant tumor variants

Tumor progression in metastasis: an experimental approach using lectin resistant tumor variants

Immunological consequences of tumor excision: From active immunity to immunological memory

Eradication of tumor cells after injection into immunized hosts compared with the eradication of tumor cells after transfer of immune peritoneal exudates into tumor-bearing recipients

Contact Info

Product

Resources

About