In Vitro Inducible Nitric Oxide Synthesis Inhibitors from Alismatis Rhizoma.

Kim, Nayoung; Kang, Taehee; Pae, Hyun‐Ock; Choi, Byung-Min; Chung, Hun‐Taeg; Myung, Seung-Woon; Song, Yun-Seon; Shon, Dong-Hwan; Kim, Youn‐Chul

doi:10.1248/bpb.22.1147

Cited by 19 publications

(7 citation statements)

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“…3A). The activity of tanshinone IIA is comparable with that of some known natural iNOS inhibitors such as alismol and alisol B monoacetate which are terpenoids [1]. The IC 50 value (20 mM) of tanshinone IIA revealed a more potent inhibitory effect than those of alismol (140 mM) and alisol B monoacetate (70 mM).…”

mentioning

confidence: 64%

Tanshinone IIA fromSalvia miltiorrhizaInhibits Inducible Nitric Oxide Synthase Expression and Production of TNF-α, IL-1β and IL-6 in Activated RAW 264.7 Cells

2003

Planta med

171

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The inhibitory effects of tanshinone IIA, a diterpene isolated from Salvia miltiorrhiza root, on the production of nitric oxide (NO), interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), and the expression of inducible nitric oxide synthase (iNOS) were investigated in activated RAW 264.7 cells. This compound markedly inhibited the production of NO, IL-1beta and TNF-alpha, and suppressed the expression of iNOS in a dose-dependent manner. These results suggest that the traditional use of S. miltiorrhiza as an anti-inflammatory herbal medicine may be explained, in part, by the inhibition of NO, IL-1beta, IL-6 and TNF-alpha production, and expression of iNOS.

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mentioning

confidence: 64%

Tanshinone IIA fromSalvia miltiorrhizaInhibits Inducible Nitric Oxide Synthase Expression and Production of TNF-α, IL-1β and IL-6 in Activated RAW 264.7 Cells

2003

Planta med

171

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“…Many terpenes has been isolated from Alisma orientale [ 25 , 26 ] which were known to have various functions including anti-type I–IV allergic response activity, anti-inflammatory activity, anti-hepatitis B virus activity, anti-tumor activity, and anti-complementarity activity [ 3 , 4 , 5 ]. Among these components, alismol is a guaiane-type sesquiterpenes that has been shown to inhibit nitric oxide synthesis in RAW 264.7 cells stimulated with interferon-gamma plus lipopolysaccharide and to suppress mainly Ca 2+ influx through a voltage-dependent Ca 2+ channel [ 27 , 28 ]. In this study, alismol significantly blocked the increase in GRP78 expression mediated by tunicamycin, whereas it did not affect the levels of CHOP and XBP-1c, suggesting that alismol might represent one of the active components of MEAO responsible for anti-ER stress and hepatic steatosis which might exert a protective effect against ER stress through the inhibition of ATF6-GRP78 pathway among the three branches of UPR.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Alisma orientale Extract against Hepatic Steatosis via Inhibition of Endoplasmic Reticulum Stress

Jang

Han

Nam

et al. 2015

IJMS

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Endoplasmic reticulum (ER) stress is associated with the pathogenesis of hepatic steatosis. Alisma orientale Juzepzuk is a traditional medicinal herb for diuretics, diabetes, hepatitis, and inflammation. In this study, we investigated the protective effects of methanol extract of the tuber of Alisma orientale (MEAO) against ER stress-induced hepatic steatosis in vitro and in vivo. MEAO inhibited the tunicamycin-induced increase in luciferase activity of ER stress-reporter constructs containing ER stress response element and ATF6 response element. MEAO significantly inhibited tunicamycin-induced ER stress marker expression including GRP78, CHOP, and XBP-1 in tunicamycin-treated Human hepatocellular carcinoma (HepG2) cells and the livers of tunicamycin-injected mice. It also inhibited tunicamycin-induced accumulation of cellular triglyceride. Similar observations were made under physiological ER stress conditions such as in palmitate (PA)-treated HepG2 cells and the livers of high-fat diet (HFD)-induced obese mice. MEAO repressed hepatic lipogenic gene expression in PA-treated HepG2 cells and the livers of HFD obese mice. Furthermore, MEAO repressed very low-density lipoprotein receptor (VLDLR) expression and improved ApoB secretion in the livers of tunicamycin-injected mice or HFD obese mice as well as in tunicamycin or PA-treated HepG2 cells. Alismol, a guaiane-type sesquiterpenes in Alisma orientale, inhibited GRP78 expression in tunicamycin-treated HepG2 cells. In conclusion, MEAO attenuates ER stress and prevents hepatic steatosis pathogenesis via inhibition of expression of the hepatic lipogenic genes and VLDLR, and enhancement of ApoB secretion.

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“…Artemisia feddei is widely used in African countries due to its ornamental and medicinal uses (Kim et al, 1999 ). The bark and leave decoction has been used as traditional remedy for digestive and inflammatory disorder (Kang et al, 1999 ).…”

Section: Natural Cox-2 and Pge 2 Inhibitor Past Pmentioning

confidence: 99%

Raging the War Against Inflammation With Natural Products

et al. 2018

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Over the last few decade Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are the drugs of choice for treating numerous inflammatory diseases including rheumatoid arthritis. The NSAIDs produces anti-inflammatory activity via inhibiting cyclooxygenase enzyme, responsible for the conversation of arachidonic acid to prostaglandins. Likewise, cyclooxegenase-2 inhibitors (COX-2) selectively inhibit the COX-2 enzyme and produces significant anti-inflammatory, analgesic, and anti-pyretic activity without producing COX-1 associated gastrointestinal and renal side effects. In last two decades numerous selective COX-2 inhibitors (COXIBs) have been developed and approved for various inflammatory conditions. However, data from clinical trials have suggested that the prolong use of COX-2 inhibitors are also associated with life threatening cardiovascular side effects including ischemic heart failure and myocardial infection. In these scenario secondary metabolites from natural product offers a great hope for the development of novel anti-inflammatory compounds. Although majority of the natural product based compounds exhibit more selectively toward COX-1. However, the data suggest that slight structural modification can be helpful in developing COX-2 selective secondary metabolites with comparative efficacy and limited side effects. This review is an effort to highlight the secondary metabolites from terrestrial and marine source with significant COX-2 and COX-2 mediated PGE2 inhibitory activity, since it is anticipated that isolates with ability to inhibit COX-2 mediated PGE2 production would be useful in suppressing the inflammation and its classical sign and symptoms. Moreover, this review has highlighted the potential lead compounds including berberine, kaurenoic acid, α-cyperone, curcumin, and zedoarondiol for further development with the help of structure–activity relationship (SAR) studies and their current status.

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In Vitro Inducible Nitric Oxide Synthesis Inhibitors from Alismatis Rhizoma.

Cited by 19 publications

References 0 publications

Tanshinone IIA fromSalvia miltiorrhizaInhibits Inducible Nitric Oxide Synthase Expression and Production of TNF-α, IL-1β and IL-6 in Activated RAW 264.7 Cells

Tanshinone IIA fromSalvia miltiorrhizaInhibits Inducible Nitric Oxide Synthase Expression and Production of TNF-α, IL-1β and IL-6 in Activated RAW 264.7 Cells

Protective Effects of Alisma orientale Extract against Hepatic Steatosis via Inhibition of Endoplasmic Reticulum Stress

Raging the War Against Inflammation With Natural Products

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