In vitro/In vivo Evaluations of Hydroxyapatite Nanoparticles with Different Geometry
Weitang Sun,
Jingbin Zhong,
Buyun Gao
et al.
Abstract:Purpose
Hydroxyapatite-based nanoparticles have found diverse applications in drug delivery, gene carriers, diagnostics, bioimaging and tissue engineering, owing to their ability to easily enter the bloodstream and target specific sites. However, there is limited understanding of the potential adverse effects and molecular mechanisms of these nanoparticles with varying geometries upon their entry into the bloodstream. Here, we used two commercially available hydroxyapatite nanoparticles (HANPs) wi… Show more
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