In vitro–in vivo evaluation of nanosuspension release from subcutaneously implantable osmotic pumps

Hill, Alexandra; Geißler, Simon; Meyring, Michael; Hecht, Stefan; Weigandt, Markus; Mäder, Karsten

doi:10.1016/j.ijpharm.2013.04.060

Cited by 11 publications

(4 citation statements)

References 41 publications

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“…The drug was delivered by subcutaneous implantation of an ALZET osmotic pump, with which drug delivery was expected to persist for up to 4 weeks (Hill et al, 2013). The concentration of SCH was adjusted to be approximately 0.1 mg/kg/d.…”

Section: Methodsmentioning

confidence: 99%

“…SCH was administered in the subject that was at second rank in the social group, based on the observation that the increase of social rank with SCH administration was the largest in second-rank subjects in mice. The drug was delivered by subcutaneous implantation of an ALZET osmotic pump, with which drug delivery was expected to persist for up to 4 weeks ( Hill et al, 2013 ). The concentration of SCH was adjusted to be approximately 0.1 mg/kg/d.…”

Section: Methodsmentioning

confidence: 99%

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The Roles of Dopamine D1 Receptor on the Social Hierarchy of Rodents and Non-human Primates

Yamaguchi

Lee

Kato

et al. 2016

IJNPPY

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Background:Although dopamine has been suggested to play a role in mediating social behaviors of individual animals, it is not clear whether such dopamine signaling contributes to attributes of social groups such as social hierarchy.Methods:In this study, the effects of the pharmacological manipulation of dopamine D1 receptor function on the social hierarchy and behavior of group-housed mice and macaques were investigated using a battery of behavioral tests.Results:D1 receptor blockade facilitated social dominance in mice at the middle, but not high or low, social rank in the groups without altering social preference among mates. In contrast, the administration of a D1 receptor antagonist in a macaque did not affect social dominance of the drug-treated animal; however, relative social dominance relationships between the drug-treated and nontreated subjects were altered indirectly through alterations of social affiliative relationships within the social group.Conclusions:These results suggest that dopamine D1 receptor signaling may be involved in social hierarchy and social relationships within a group, which may differ between rodents and primates.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

The Roles of Dopamine D1 Receptor on the Social Hierarchy of Rodents and Non-human Primates

Yamaguchi

Lee

Kato

et al. 2016

IJNPPY

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“…In consideration to the barriers presented by diffusion across the RWM and Eustachian tube clearance rates, devices and modifications have been formulated to mitigate these challenges, improving ITD delivery [ 95 , 98 , 117 , 118 , 119 ]. Increasing the viscosity or mucosal adherence properties of an applied drug reduces Eustachian tube clearance, as seen in hydrogels [ 120 , 121 , 122 ].…”

Section: Local Drug Delivery Of Antioxidants To Inner Earmentioning

confidence: 99%

A Review on Recent Advancement on Age-Related Hearing Loss: The Applications of Nanotechnology, Drug Pharmacology, and Biotechnology

et al. 2021

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Aging is considered a contributing factor to many diseases such as cardiovascular disease, Alzheimer’s disease, and hearing loss. Age-related hearing loss, also termed presbycusis, is one of the most common sensory impairments worldwide, affecting one in five people over 50 years of age, and this prevalence is growing annually. Associations have emerged between presbycusis and detrimental health outcomes, including social isolation and mental health. It remains largely untreatable apart from hearing aids, and with no globally established prevention strategies in the clinical setting. Hence, this review aims to explore the pathophysiology of presbycusis and potential therapies, based on a recent advancement in bile acid-based bio-nanotechnologies. A comprehensive online search was carried out using the following keywords: presbycusis, drugs, hearing loss, bile acids, nanotechnology, and more than 150 publications were considered directly relevant. Evidence of the multifaceted oxidative stress and chronic inflammation involvement in cellular damage and apoptosis that is associated with a loss of hair cells, damaged and inflamed stria vascularis, and neuronal signalling loss and apoptosis continues to emerge. New robust and effective therapies require drug delivery deeper into the various layers of the cochlea. Bile acid-based nanotechnology has gained wide interest in its permeation-enhancing ability and potential for numerous applications in treating presbycusis.

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“…1,3,[5][6][7][8][11][12][13][26][27][28][29][30] State of the art implantable micro-devices include reservoir-based systems, controlled-release microchips, and various electrically powered microsystems. 1,2,10,31 Osmotic pumps present a convenient and reliable cost-effective drug delivery method capable of replacing repeated injections of soluble and poorly soluble drugs 32,33 for the treatment of chronically debilitating diseases. 3,4,[34][35][36] These marketed pumps use the principle of osmotic pressure for the delivery of pharmaceutical ingredients at a predetermined rate 37 and eliminate the need for frequent handling and injections, without external connectors.…”

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confidence: 99%

Osmotically driven drug delivery through remote-controlled magnetic nanocomposite membranes

Zaher

Wolf

et al. 2015

Biomicrofluidics

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Implantable drug delivery systems can provide long-term reliability, controllability, and biocompatibility, and have been used in many applications, including cancer pain and non-malignant pain treatment. However, many of the available systems are limited to zero-order, inconsistent, or single burst event drug release. To address these limitations, we demonstrate prototypes of a remotely operated drug delivery device that offers controllability of drug release profiles, using osmotic pumping as a pressure source and magnetically triggered membranes as switchable on-demand valves. The membranes are made of either ethyl cellulose, or the proposed stronger cellulose acetate polymer, mixed with thermosensitive poly(N-isopropylacrylamide) hydrogel and superparamagnetic iron oxide particles. The prototype devices' drug diffusion rates are on the order of 0.5-2 lg/h for higher release rate designs, and 12-40 ng/h for lower release rates, with maximum release ratios of 4.2 and 3.2, respectively. The devices exhibit increased drug delivery rates with higher osmotic pumping rates or with magnetically increased membrane porosity. Furthermore, by vapor deposition of a cyanoacrylate layer, a drastic reduction of the drug delivery rate from micrograms down to tens of nanograms per hour is achieved. By utilizing magnetic membranes as the valve-control mechanism, triggered remotely by means of induction heating, the demonstrated drug delivery devices benefit from having the power source external to the system, eliminating the need for a battery. These designs multiply the potential approaches towards increasing the on-demand controllability and customizability of drug delivery profiles in the expanding field of implantable drug delivery systems, with the future possibility of remotely controlling the pressure source. V C 2015 AIP Publishing LLC. [http://dx

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In vitro–in vivo evaluation of nanosuspension release from subcutaneously implantable osmotic pumps

Cited by 11 publications

References 41 publications

The Roles of Dopamine D1 Receptor on the Social Hierarchy of Rodents and Non-human Primates

The Roles of Dopamine D1 Receptor on the Social Hierarchy of Rodents and Non-human Primates

A Review on Recent Advancement on Age-Related Hearing Loss: The Applications of Nanotechnology, Drug Pharmacology, and Biotechnology

Osmotically driven drug delivery through remote-controlled magnetic nanocomposite membranes

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