In vitro-in vivo correlation (IVIVC) of solid lipid nanoparticles loaded with poorly water-soluble drug lovastatin

Sarangi, Babita; Mishra, Kirtimaya; Mohanta, Guru Prasad; Manna, P. K.

doi:10.1016/j.eurpolymj.2019.109366

Cited by 5 publications

(3 citation statements)

References 36 publications

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“…The use of CCRD coupled with RSM is considered as the alternative approach for optimizing the production of nanoparticles since it is possible to analyze several variables at different levels with a reduce number of experiments [ 29 , 30 ]. Herein, sixteen batches were formulated according to CCRD-RSM, and the results of the hydrodynamic diameter, polydispersity index, and zeta potential of the particles and drug entrapment efficiency are shown in Table 2 .…”

Section: Resultsmentioning

confidence: 99%

Cashew Gum Polysaccharide Nanoparticles Grafted with Polypropylene Glycol as Carriers for Diclofenac Sodium

et al. 2021

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This investigation focuses on the development and optimization of cashew gum polysaccharide (CGP) nanoparticles grafted with polypropylene glycol (PPG) as carriers for diclofenac sodium. The optimization of parameters affecting nanoparticles formulation was performed using a central composite rotatable design (CCRD). It was demonstrated that the best formulation was achieved when 10 mg of CGP was mixed with 10 μL of PPG and homogenized at 22,000 rpm for 15 min. The physicochemical characterization evidenced that diclofenac was efficiently entrapped, as increases in the thermal stability of the drug were observed. The CGP-PPG@diclofenac nanoparticles showed a globular shape, with smooth surfaces, a hydrodynamic diameter around 275 nm, a polydispersity index (PDI) of 0.342, and a zeta potential of −5.98 mV. The kinetic studies evidenced that diclofenac release followed an anomalous transport mechanism, with a sustained release up to 68 h. These results indicated that CGP-PPG nanoparticles are an effective material for the loading/release of drugs with similar structures to diclofenac sodium.

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Section: Resultsmentioning

confidence: 99%

Cashew Gum Polysaccharide Nanoparticles Grafted with Polypropylene Glycol as Carriers for Diclofenac Sodium

et al. 2021

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“…Lovastatin belongs to BCS class II, has a naphthalene ring and a lactone ring, where the lactone ring binds to the 3-hydroxy-3methylglutaryl-coenzym A (HMG-CoA) reductase enzyme and inhibits the formation of cholesterol. Lovastatin shows low oral bioavailability (< 5%) because of least absorption and rapid metabolism in the liver [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…(2) The superior properties of nanosponges have been attributed to 'tunability', that is the ability to control the structure of particles and control the nature and size of aperture. (3) Nanosponges have the ability to produce predictable/controlled drug release [5]. (4) Nanosponges can be tagged with specific linkers to target diseased cells hence achieving greater efficacy while reducing side-effects, decreasing dose and dosing frequency and in turn increasing patient compliance.…”

Section: Introductionmentioning

confidence: 99%

Formulation and evaluation of lovastatin loaded nanosponges

Pushpalatha¹,

Khan²,

Manjunath³

et al. 2021

World J. Adv. Res. Rev.

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Nanotechnology mediated drug delivery has been reported to enhance the drug efficacy, bioavailability, reduced toxicity and improve patient compliance by targeting the cells and tissues to elicit the desired pharmacological action. The main aim of the study was to formulate lovastatin loaded nanosponges and to evaluate them. Lovastatin loaded nanosponges were prepared by Emulsion solvent diffusion method using different polymers (Ethyl cellulose, Polyvinyl alcohol, β-cyclodextrin, Pluronic F68, Hydroxy Propyl β- cyclodextrin). The FTIR test is conducted as the preliminary test, by this test there was no interaction between the drug and polymers. Then nanosponges were evaluated for particle size, PDI, zeta potential, SEM, entrapment efficiency and invitro drug release. The particle size ranged from 295.5 to 578.8 nm, PDI ranged from 0.189 to 0.465, zeta potential from -17.3 to -35.96 mV and entrapment efficiency was ranged from 78.38 to 95.77 %. The cumulative percentage release from all nanosponges varied from 66.86 to 96.60% after 12 hours depending upon the drug and polymers ratio andF6 formulation showed highest drug release i.e., 96.60%. The release kinetic studies showed that the release first order diffusion controlled and the n value (0.6017) from the Korsmeyer-Peppa’s model indicated the release mechanism was non-fickian type.

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Reactive Oxygen Species Scavenging Nanomedicine for the Treatment of Ischemic Heart Disease

Zhang

Dalan

et al. 2022

Advanced Materials

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Ischemic heart disease (IHD) is the leading cause of disability and mortality worldwide. Reactive oxygen species (ROS) have been shown to play key roles in the progression of diabetes, hypertension, and hypercholesterolemia, which are independent risk factors that lead to atherosclerosis and the development of IHD. Engineered biomaterial‐based nanomedicines are under extensive investigation and exploration, serving as smart and multifunctional nanocarriers for synergistic therapeutic effect. Capitalizing on cell/molecule‐targeting drug delivery, nanomedicines present enhanced specificity and safety with favorable pharmacokinetics and pharmacodynamics. Herein, the roles of ROS in both IHD and its risk factors are discussed, highlighting cardiovascular medications that have antioxidant properties, and summarizing the advantages, properties, and recent achievements of nanomedicines that have ROS scavenging capacity for the treatment of diabetes, hypertension, hypercholesterolemia, atherosclerosis, ischemia/reperfusion, and myocardial infarction. Finally, the current challenges of nanomedicines for ROS‐scavenging treatment of IHD and possible future directions are discussed from a clinical perspective.

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In vitro-in vivo correlation (IVIVC) of solid lipid nanoparticles loaded with poorly water-soluble drug lovastatin

Cited by 5 publications

References 36 publications

Cashew Gum Polysaccharide Nanoparticles Grafted with Polypropylene Glycol as Carriers for Diclofenac Sodium

Cashew Gum Polysaccharide Nanoparticles Grafted with Polypropylene Glycol as Carriers for Diclofenac Sodium

Formulation and evaluation of lovastatin loaded nanosponges

Reactive Oxygen Species Scavenging Nanomedicine for the Treatment of Ischemic Heart Disease

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