In-vitro/in-vivo characterization of trans-resveratrol-loaded nanoparticulate drug delivery system for oral administration

Abstract

The results, therefore, insight into the role of solubility enhancement and trounce enterohepatic recirculation for improving the oral bioavailability of t-RVT.

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

“…176 Their research group also studied sustained release of trans-resveratrol in vitro and found higher solubility and dissolubility of trans-resveratrol. 68,175,176 In addition, a combination of one or two nanosized bioactive compounds has multiple health beneficial effects for certain diseases, which further reduces the multiple drug load. Curcumin and resveratrol encapsulated nanoliposomes have an antitumor effect against prostate cancer.…”

“…Nanoencapsulation protects trans-resveratrol from this rapid conversion and enhances its bioavailability in systematic circulation for prolonged activity. 68,175 PLGA-coated resveratrol nanoparticles enhance the bioavailability of resveratrol for up to 4 days in a rat model. 176 Their research group also studied sustained release of trans-resveratrol in vitro and found higher solubility and dissolubility of trans-resveratrol.…”

“…34,152,162 Resveratrol has multiple health benefits, including antiaging, anticancer, cardioprotective, and PD protective effects. 66,68,145 Resveratrol exists in cis and trans forms, in which trans-resveratrol is more stable than cis-resveratrol which is pharmacologically less active. 66 Trans-resveratrol is readily converted to cis-resveratrol when exposed to sunlight for 1 hour; therefore, protecting these compounds is biologically more important for a sustained effect.…”

“…Trans-resveratrol loaded nanoparticle systems and optimized self nanoemulsifying systems enhance bioavailability fivefold to various target sites because of the optimum formulation. 68,69 Recently, nanotechnology-based approach of treatment gained more importance for the enhanced crossing blood-brain barrier through its unique nanosize to various brain diseases, such as PD, brain cancer, and Alzheimer's disease. 70 The role of nanotechnology in reducing oxidative stress in PD Nanotechnology plays a very significant role in reducing oxidative stress that occurs in various diseases, including cancers, Alzheimer's disease, and PD.…”

“…16,29,35 Nanosized bioactive compounds vary in the size from 10 to 1,000 nm, which increases bioactivity and target specificity, reduces toxicity, and enhances safety. 17,29,33,34,68,72,73 The most important characteristics of nanoparticles delivered to the PD brain include the size of the bioactive compound, surface activity, and carrier toxicity. 17,33,73 Figure 1 Nano phytobioactive compounds mechanism of action against Parkinson's disease pathway.…”