In Vitro, In Vivo and In Silico Analysis of the Anticancer and Estrogen-like Activity of Guava Leaf Extracts

Rizzo, Larissa Yokota; Longato, Giovanna Barbarini; Ruiz, Amalia; Tinti, Sirlene Valério; Possenti, Ana; Vendramini–Costa, Débora Barbosa; Sartoratto, Adilson; Figueira, Glyn Mara; Silva, F.L.N.; Eberlin, Marcos N.; Souza, T.A.C.B.; Murakami, Mami; Rizzo, Elizete; Foglio, Mary Ann; Kießling, Fabian; Lammers, Twan; Carvalho, J.C.T.

doi:10.2174/0929867321666140120120031

Cited by 29 publications

(24 citation statements)

References 12 publications

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“…The results suggested that these compounds may act as phytoestrogens, presenting tissue-specific antagonistic and agonistic activity on estrogen receptors [43]. These data partially confirmed the results in vitro obtained by Ryu et al [47].…”

Section: Pharmacological Propertiessupporting

confidence: 81%

“…Regarding the bioactivity of terpenes from guava, an enriched mixture of guajadial, psidial A, and psiguadial A and B proved anti-proliferative effect for nine human cancer lines: leukemia (K-562), breast (MCF-7), resistant ovarian cancer (NCI/ADR-RES), lung (NCI-H460), melanoma (UACC-62), prostate (PC-3), colon (HT-29), ovarian (OVCAR-3), and kidney (786-0) [43]. The apoptotic effect of β-caryophyllene oxide (CPO) on MCF-7 and PC-3 cell lines was also demonstrated because of its ability to interfere with multiple signaling cascades involved in tumor genesis [44].…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

See 1 more Smart Citation

Health Effects of Psidium guajava L. Leaves: An Overview of the Last Decade

Díaz‐de‐Cerio

Verardo

Gómez-Caravaca

et al. 2017

IJMS

118

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Today, there is increasing interest in discovering new bioactive compounds derived from ethnomedicine. Preparations of guava (Psidium guajava L.) leaves have traditionally been used to manage several diseases. The pharmacological research in vitro as well as in vivo has been widely used to demonstrate the potential of the extracts from the leaves for the co-treatment of different ailments with high prevalence worldwide, upholding the traditional medicine in cases such as diabetes mellitus, cardiovascular diseases, cancer, and parasitic infections. Moreover, the biological activity has been attributed to the bioactive composition of the leaves, to some specific phytochemical subclasses, or even to individual compounds. Phenolic compounds in guava leaves have been credited with regulating blood-glucose levels. Thus, the aim of the present review was to compile results from in vitro and in vivo studies carried out with guava leaves over the last decade, relating the effects to their clinical applications in order to focus further research for finding individual bioactive compounds. Some food applications (guava tea and supplementary feed for aquaculture) and some clinical, in vitro, and in vivo outcomes are also included.

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Section: Pharmacological Propertiessupporting

confidence: 81%

Section: Pharmacological Propertiesmentioning

confidence: 99%

Health Effects of Psidium guajava L. Leaves: An Overview of the Last Decade

Díaz‐de‐Cerio

Verardo

Gómez-Caravaca

et al. 2017

IJMS

118

View full text Add to dashboard Cite

show abstract

“…The ability of the meroterpene-enriched fraction to reduce tumor growth and stimulate uterus proliferation, suggest that these compounds may act as Selective Estrogen Receptors Modulators. 97 Kim et al 98 also isolated β-caryophyllene oxide from the essential oils of P. guajava and O. vulgare. β-caryophyllene oxide suppressed constitutive STAT3 activation in multiple myeloma, prostate cancer and breast cancer cell lines.…”

mentioning

confidence: 99%

Phytopharmacological overview of Psidium guajava Linn.

Anand¹,

Manikandan²,

Kumar³

et al. 2016

Phcogj

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Psidium guajava Linn. possesses useful medicinal benefits. It has been recognized as the medicinally essential phytoconstituents, such as phenolic, flavonoid and carotenoid. Numerous pharmacological investigation have confirmed that the ability of this plant is to exhibit antimicrobial, antidiabetic, cardioprotective, neuroprotective, hepatoprotective, antioxidant and anticancer activities and it supports the traditional uses. This is a comprehensive of the phytoconstituents and pharmacological benefits.

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“…Our research group have demonstrated that guava's dichloromethane leaves extract and the mixture of guajadial (1), psidial A (2), psiguadial A and B presented significant in vitro antiproliferative effect against nine human cancer lines [16]. More, this in vitro effect was translated into tumor growth inhibition in Ehrlich's solid tumor model besides anti-estrogenic activity evidenced by the uterotrophic model where animals were treated through the intraperitoneal route.…”

Section: Introductionmentioning

confidence: 94%

Anti-Estrogenic Activity of Guajadial Fraction, from Guava Leaves (Psidium guajava L.)

et al. 2020

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The research of natural products has allowed for the discovery of biologically relevant compounds inspired by plant secondary metabolites, which contributes to the development of many chemotherapeutic drugs used in cancer treatment. Psidium guajava leaves present a diverse phytochemical composition including flavonoids, phenolics, meroterpenoids, and triterpenes as the major bioactive constituents. Guajadial, a caryophyllene-based meroterpenoid, has been studied for potential anticancer effects tested in tumor cells and animal experimental models. Moreover, guajadial has been reported to have a mechanism of action similar to tamoxifen, suggesting this compound as a promisor phytoestrogen-based therapeutic agent. Herein, the anti-estrogenic action and anti-proliferative activity of guajadial is reported. The enriched guajadial fraction was obtained by sequential chromatographic techniques from the crude P. guajava dichloromethane extract showing promising anti-proliferative activity in vitro with selectivity for human breast cancer cell lines MCF-7 and MCF-7 BUS (Total Growth Inhibition = 5.59 and 2.27 µg·mL−1, respectively). Furthermore, evaluation of anti-estrogenic activity in vivo was performed demonstrating that guajadial enriched fraction inhibited the proliferative effect of estradiol on the uterus of pre-pubescent rats. These results suggest a relationship between anti-proliferative and anti-estrogenic activity of guajadial, which possibly acts in tumor inhibition through estrogen receptors due to the compounds structural similarity to tamoxifen.

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In Vitro, In Vivo and In Silico Analysis of the Anticancer and Estrogen-like Activity of Guava Leaf Extracts

Cited by 29 publications

References 12 publications

Health Effects of Psidium guajava L. Leaves: An Overview of the Last Decade

Health Effects of Psidium guajava L. Leaves: An Overview of the Last Decade

Phytopharmacological overview of Psidium guajava Linn.

Anti-Estrogenic Activity of Guajadial Fraction, from Guava Leaves (Psidium guajava L.)

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