In vitro, in vivo and in silico antiulcer activity of ferulic acid

Umre, Ratika; Ganeshpurkar, Aditya; Ganeshpurkar, Ankit; Pandey, Stuti; Pandey, Vikas; Shrivastava, Abhishek; Dubey, Nazneen

doi:10.1016/j.fjps.2018.08.001

Cited by 36 publications

(18 citation statements)

References 23 publications

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“…It was reported that ferulic acid has antidiabetic, hepatoprotective, anticancer, anti-apoptotic, and anti-aging properties [24]. Phthalides are considered to be major bioactive compounds, possessing various activities with anti-tumor, neuroprotective, nephroprotective, analgesic, and anti-angiogenic effects [25].…”

Section: Resultsmentioning

confidence: 99%

Identification of Chemical Markers for the Discrimination of Radix Angelica sinensis Grown in Geoherb and Non-Geoherb Regions Using UHPLC-QTOF-MS/MS Based Metabolomics

et al. 2019

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This research aimed to discover chemical markers for discriminating radix Angelica sinensis (RAS) from different regions and to explore the differences of RAS in the content of four active compounds and anti-inflammatory activities on lipopolysacchride (LPS)-induced RAW264.7 cells and calcium antagonists on the HEK 293T cells of RAS. Nine compounds were selected as characteristic chemical markers by ultra-high-performance liquid chromatography-quadrupole/time-of-flight mass spectrometry (UHPLC-QTOF-MS/MS), based on metabolomics, in order to rapidly discriminate RAS from geoherb and non-geoherb regions. The contents of senkyunolide I and butylidenephthalide in geoherb samples were higher than those in non-geoherb samples, but the contents of ferulic acid and levistolide A were lower in the geoherb samples. Furthermore, the geoherbs showed better nitric oxide (NO) inhibitory and calcium antagonistic activities than the non-geoherbs. These results demonstrate the diversity in quality of RAS between geoherbs and non-geoherbs.

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Section: Resultsmentioning

confidence: 99%

Identification of Chemical Markers for the Discrimination of Radix Angelica sinensis Grown in Geoherb and Non-Geoherb Regions Using UHPLC-QTOF-MS/MS Based Metabolomics

et al. 2019

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“…[ 1 , 2 ]. FA is known as an antiaging [ 3 ], anti-inflammatory [ 4 ], antithrombotic [ 5 ], antidiabetic [ 6 ], antiulcerigen [ 7 ], antihemolitic [ 8 ], antiviral [ 9 ] and even anti-carcinogenic agent [ 10 ]. Due to the antibacterial effect, it may also be used in certain implants [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Development of a Novel Electrochemical Biosensor Based on Carbon Nanofibers–Gold Nanoparticles–Tyrosinase for the Detection of Ferulic Acid in Cosmetics

Bounegru

Apetrei

2020

Sensors

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The present paper deals with the electrochemical behavior of three types of sensors based on modified screen-printed electrodes (SPEs): a sensor based on carbon nanofibers (CNF/SPE), a sensor based on nanofibers of carbon modified with gold nanoparticles (CNF-GNP/SPE) and a biosensor based on nanofibers of carbon modified with gold nanoparticles and tyrosinase (CNF-GNP-Ty/SPE). To prepare the biosensor, the tyrosinase (Ty) was immobilized on the surface of the electrode already modified with carbon nanofibers and gold nanoparticles, by the drop-and-dry technique. The electrochemical properties of the three electrodes were studied by cyclic voltammetry in electroactive solutions, and the position and shape of the active redox peaks are according to the nature of the materials modifying the electrodes. In the case of ferulic acid, a series of characteristic peaks were observed, the processes being more intense for the biosensor, with the higher sensitivity and selectivity being due to the immobilization of tyrosinase, a specific enzyme for phenolic compounds. The calibration curve was subsequently created using CNF-GNP-Ty/SPE in ferulic acid solutions of various concentrations in the range 0.1–129.6 μM. This new biosensor allowed low values of the detection threshold and quantification limit, 2.89 × 10−9 mol·L−1 and 9.64 × 10−9 mol·L−1, respectively, which shows that the electroanalytical method is feasible for quantifying ferulic acid in real samples. The ferulic acid was quantitatively determined in three cosmetic products by means of the CNF-GNP-Ty/SPE biosensor. The results obtained were validated by means of the spectrometric method in the infrared range, the differences between the values of the ferulic acid concentrations obtained by the two methods being under 5%.

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“… Blood Glucose Level (Using Digital Glucometer, One touch select, LifeScan Scotland Ltd, UK), Serum Insulin, Pancreatic Insulin (Sandwich ELISA Assay), C-peptide, Hb1Ac (Span Diagnostic), and Lipid Profile (DELTA LABS Kit, Bangalore, India)  Measurement of Pro-Inflammatory Cytokines, Markers of disease severity; Il-6, IL-1beta, and TNF-alpha by Sandwich ELISA Assay (Commercial Available kit, Mercodia, Sweden) [33][34][35][36][37].  Antioxidant Enzyme Studies: Lipid Peroxidation (LPO) [38,39], Reduced Glutathione (GSH) [40,41], Superoxide dismutase (SOD) [42], and Catalase (CAT) [43].  Histopathology Study: Pancreas [44]…”

Section: Acute Oral Toxicity Studymentioning

confidence: 99%

Anti-Type I Diabetic Activity of the Methanolic Extract of Aegle marmelos on Streptozotocin Induced Rat Model

Haimed¹,

Sharma²,

Jha³

2022

JPRI

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Aegle marmelos, generally acknowledged as Bael, is being ancient in Ayurveda for the therapy of a number of disorders. All the components on it tree along with stem, bark, root, leaves, fruit and seeds at all stages of maturity have medicinal virtues and have been recorded in Ethno-medicine. Aims: The present investigation study the Anti-Type I diabetic activity of the methanolic extract of Aegle marmelos on STZ induced rat model. Study Design: In-vivo study in rat model Place and Duration of Study: Department of Pharmacology, Karnataka college of Pharmacy, Bangalore, India, between Jan 2021 to Dec 2021. Methodology: Extracted Aegle marmelos was to be evaluated the toxicity as per the OECD guidelines and biochemical, hematological and gross pathological analysis has been assessed. Type I Diabetes has been induced in Wistar rats through STZ 65mg/kg/b.w. I.P. During the experiment, Rat’s BW and FBS level were monitored. At the end of study, animals among all groups namely Group I: Normal control, Group II: STZ 65mg/kg, Group III: STZ + Insulin 4Ukg/b.w., Group IV: Aegle marmelos 250mg/kg and Group V: Aegle marmelos 500mg/kg were sacrificed and biochemical parameters like Lipid profile, C-Peptide, HbA1c, Serum insulin, pancreatic insulin, and histology of pancreas had been observed. Aegle marmelos was also screened for pro-inflammatory cytokines viz., IL-1β, IL-6 and TNF-α were assessed by ELISA test. Furthermore, Antioxidant Enzyme like SOD, CAT, LPO and GSH were performed. Results: The observed extract Aegle marmelos was shown safe in the toxicity data; B.W, Lipid Profile, RFT, LFT, hematological parameters were shown in the limit range and the vital organ tissue histology were not shown any anatomical and structural abnormalities. The findings of the other parameters have been shown significant impact in vivo to manage the diabetic markers like weight gain, blood glucose, lipid profile, C-Peptide, HbA1c, secretion of insulin, and pancreatic insulin. Diabetic pancreas of rats confirmed fall of beta cell density and disruption of normal architecture. But treated group were found to restore the mass of beta cells. Mediator of inflammatory cytokines like increased in STZ group and was inhibited by test chemicals. Elevated oxidative enzymes also have been seen to control upon the treatment with Aegle marmelos. Conclusion: All this findings and phytoconstituents present within the extract should be the possible chemical substances concerned in the prevention of diabetes.

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In vitro, in vivo and in silico antiulcer activity of ferulic acid

Cited by 36 publications

References 23 publications

Identification of Chemical Markers for the Discrimination of Radix Angelica sinensis Grown in Geoherb and Non-Geoherb Regions Using UHPLC-QTOF-MS/MS Based Metabolomics

Identification of Chemical Markers for the Discrimination of Radix Angelica sinensis Grown in Geoherb and Non-Geoherb Regions Using UHPLC-QTOF-MS/MS Based Metabolomics

Development of a Novel Electrochemical Biosensor Based on Carbon Nanofibers–Gold Nanoparticles–Tyrosinase for the Detection of Ferulic Acid in Cosmetics

Anti-Type I Diabetic Activity of the Methanolic Extract of Aegle marmelos on Streptozotocin Induced Rat Model

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