In vitro importance of probiotic Lactobacillus plantarum related to medical field

Abstract

Lactobacillus plantarum is a Gram positive lactic acid bacterium commonly found in fermented food and in the gastro intestinal tract and is commonly used in the food industry as a potential starter probiotic. Recently, the consumption of food together with probiotics has tremendously increased. Among the lactic acid bacteria, L. plantarum attracted many researchers because of its wide applications in the medical field with antioxidant, anticancer, anti-inflammatory, antiproliferative, anti-obesity and antidiabetic properties. The present study aimed to investigate the in vitro importance of L. plantarum toward medical applications. Moreover, this report short listed various reports related to the applications of this promising strain. In conclusion, this study would attract the researchers in commercializing this strain toward the welfare of humans related to medical needs.

Lactobacillus plantarum and Lactobacillus fermentum alone or in combination regulate intestinal flora composition and systemic immunity to alleviate obesity syndrome in high‐fat diet rat

“…This led us suppose that the change of intestinal flora artificially may have some effects on high‐fat diet rat. Studies showed that LP has some effects in regulating humoral immunity and cholesterol‐lowering effects (Ushakova et al ., ; Yoo et al ., ; Arasu et al ., ), while LF has lipid‐lowing function and can alter the intestinal microflora (Tomaro‐Duchesneau et al ., ; Liu et al ., ). So it is our purpose to use these two strains in combination to study their effects on high‐fat diet rats.…”

“…Lactobacillus Plantarum (LP) has been studied extensively for its antioxidation, anticancer, antiobesity, etc. Therefore, this strain has been used extensively (Costilow & Humphreys, 1955;Yoo et al, 2013;Arasu et al, 2016). Lactobacillus fermentum (LF) has also been used to alter the intestinal flora and thus showing its healthy effects (Liu et al, 2014).…”

In vitro antifungal, probiotic, and antioxidant functional properties of a novel Lactobacillus paraplantarum isolated from fermented dates in Saudi Arabia

“…The growth pattern of the strain was measured intermittently, and extracellular metabolites, such as acetic acid, succinic acid, lactic acid, and ethanol, were quantified by HPLC. 16,17 Cultivation and purification of antimicrobial components The initial antimicrobial screening results confirmed that the Lactobacillus strain D-3 exhibited promising activity with stability for a wide range of hydrolytic enzymes, acids, and organic solvents. 18 Therefore, after cultivation, the supernatant was mixed with different organic solvents, such as hexane, chloroform, ethyl acetate, and methanol, to improve antimicrobial component yields.…”

“…Similarly, the metabolite production ability of the strains using date syrup was also investigated. The growth pattern of the strain was measured intermittently, and extracellular metabolites, such as acetic acid, succinic acid, lactic acid, and ethanol, were quantified by HPLC …”

“…Moreover, LAB are approved by the food authorities as a generally safe component for use in food . Interestingly, LAB also have other biological applications, such as reducing hypertension, stimulating the production of pro‐inflammatory cytokines for the treatment of cancer, degrading kidney stones, minimizing cholesterol level in adipose tissues, inducing humoral and mucosal immune responses in the human brain, maintaining postmenopausal hormones in women, enhancing the expression of human keratinocytes, and acting as anti‐obesity and antioxidant agents . However, the importance of LAB is strain specific .…”