In vitro immune responses of human peripheral blood mononuclear cells to silk fibroin: IL-10 stimulated anti-inflammatory and hypoallergenic properties

Chancheewa, Bussabong; Buranapraditkun, Supranee; Laomeephol, Chavee; Rerknimitr, Pawinee; Kanokpanont, Sorada; Damrongsakkul, Siriporn; Klaewsongkram, Jettanong

doi:10.1016/j.mtcomm.2020.101044

Cited by 4 publications

(4 citation statements)

References 34 publications

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“…Recently, silk fibroin was also shown to promote the release of IL‐10 from peripheral blood mononuclear cells (PBMCs). [ 125 ] Interestingly, silk fibroin possesses intrinsic ability to accelerate the wound healing via NF‐ κβ signaling. In view of this, extensive studies have been performed in various types of injures to manage the wound healing process using silk fibroin.…”

Section: Immunomodulatory Hydrogels For Chronic Skin Woundsmentioning

confidence: 99%

Rational Design of Immunomodulatory Hydrogels for Chronic Wound Healing

2021

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With all the advances in tissue engineering for construction of fully functional skin tissue, complete regeneration of chronic wounds is still challenging. Since immune reaction to the tissue damage is critical in regulating both the quality and duration of chronic wound healing cascade, strategies to modulate the immune system are of importance. Generally, in response to an injury, macrophages switch from pro‐inflammatory to an anti‐inflammatory phenotype. Therefore, controlling macrophages’ polarization has become an appealing approach in regenerative medicine. Recently, hydrogels‐based constructs, incorporated with various cellular and molecular signals, have been developed and utilized to adjust immune cell functions in various stages of wound healing. Here, the current state of knowledge on immune cell functions during skin tissue regeneration is first discussed. Recent advanced technologies used to design immunomodulatory hydrogels for controlling macrophages’ polarization are then summarized. Rational design of hydrogels for providing controlled immune stimulation via hydrogel chemistry and surface modification, as well as incorporation of cell and molecules, are also dicussed. In addition, the effects of hydrogels’ properties on immunogenic features and the wound healing process are summarized. Finally, future directions and upcoming research strategies to control immune responses during chronic wound healing are highlighted.

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Section: Immunomodulatory Hydrogels For Chronic Skin Woundsmentioning

confidence: 99%

Rational Design of Immunomodulatory Hydrogels for Chronic Wound Healing

2021

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“…On the other hand, anti-inflammatory reactions are also integral to the wound-healing process, working in a cycle with pro-inflammatory responses to maintain a balanced and controlled environment. Certain biomaterials are crafted to foster an anti-inflammatory environment by engaging with pathways like TGF-β/Smad [ 133 ], peroxisome proliferator-activated receptor-γ (PPAR-γ) [ 134 ], Janus kinase- signal transducers activators of transcription (JAK-STAT) [ 126 ], promoting the release of anti-inflammatory cytokines, such as IL-4 [ 135 ], IL-10 [ 136 ] and IL-13 [ 137 ], and facilitating the transition to tissue repair. For example, the incorporation of curcumin nanoparticles into collagen-chitosan scaffolds significantly enhances cutaneous wound healing in a rat model, as evidenced by accelerated vessel formation, greater granulation tissue density and enhanced collagen content, with a simultaneous regulation of TGF-β1 and Smad7 mRNA expression, emphasizing the anti-inflammatory and regulatory effects of the biomaterials on the wound-healing process [ 133 ].…”

Section: Modulating Innate Immunity In the New Generation Of Wound-he...mentioning

confidence: 99%

Biomaterials for immunomodulation in wound healing

Wang,

Vizely,

et al. 2024

Regenerative Biomaterials

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The substantial economic impact of nonhealing wounds, scarring, and burns stemming from skin injuries is evident, resulting in a financial burden on both patients and the healthcare system. This review paper provides an overview of the skin's vital role in guarding against various environmental challenges as the body's largest protective organ and associated developments in biomaterials for wound healing. We first introduce the composition of skin tissue and intricate processes of wound healing, with special attention to the crucial role of immunomodulation in both acute and chronic wounds. This highlights how the imbalance in the immune response, particularly in chronic wounds associated with underlying health conditions such as diabetes and immunosuppression, hinders normal healing stages. Then, this review distinguishes between traditional wound healing strategies that create an optimal microenvironment and recent peptide-based biomaterials that modulate cellular processes and immune response to facilitate wound closure. Additionally, we highlight the importance of considering the stages of wounds in the healing process. By integrating advanced materials engineering with an in-depth understanding of wound biology, this approach holds promise for reshaping the field of wound management and ultimately offering improved outcomes for patients with acute and chronic wounds.

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“…[ [23][24][25][26] Antibacterial SF naturally lacks inherent antibacterial activity, requiring the combination of anti-bacterial agents. [27,28] Metabolic regulation activity (anti-diabetic) SF exerts anti-diabetic effects by increasing pancreatic β cell mass in a non-insulin dependent diabetes mellitus mouse model and enhances insulin secretion.…”

Section: Properties Observations Referencesmentioning

confidence: 99%

Sustainable Silk-Based Particulate Systems for the Controlled Release of Pharmaceuticals and Bioactive Agents in Wound Healing and Skin Regeneration

Bernardes,

Veiga,

Barros

et al. 2024

IJMS

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The increasing demand for innovative approaches in wound healing and skin regeneration has prompted extensive research into advanced biomaterials. This review focuses on showcasing the unique properties of sustainable silk-based particulate systems in promoting the controlled release of pharmaceuticals and bioactive agents in the context of wound healing and skin regeneration. Silk fibroin and sericin are derived from well-established silkworm production and constitute a unique biocompatible and biodegradable protein platform for the development of drug delivery systems. The controlled release of therapeutic compounds from silk-based particulate systems not only ensures optimal bioavailability but also addresses the challenges associated with conventional delivery methods. The multifaceted benefits of silk proteins, including their inherent biocompatibility, versatility, and sustainability, are explored in this review. Furthermore, the intricate mechanisms by which controlled drug release takes place from silk-based carriers are discussed.

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In vitro immune responses of human peripheral blood mononuclear cells to silk fibroin: IL-10 stimulated anti-inflammatory and hypoallergenic properties

Cited by 4 publications

References 34 publications

Rational Design of Immunomodulatory Hydrogels for Chronic Wound Healing

Rational Design of Immunomodulatory Hydrogels for Chronic Wound Healing

Biomaterials for immunomodulation in wound healing

Sustainable Silk-Based Particulate Systems for the Controlled Release of Pharmaceuticals and Bioactive Agents in Wound Healing and Skin Regeneration

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