In vitro hydrolysis of poly(l-lactide) crystalline residues as extended-chain crystallites. Part I: long-term hydrolysis in phosphate-buffered solution at 37°C

Tsuji, Hideto; Ikarashi, Kensaku

doi:10.1016/j.biomaterials.2003.12.053

Cited by 86 publications

(71 citation statements)

References 43 publications

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“…With increase in hydrolytic degradation, PLLA tends to show a decrease in average molecular weight, a slow rise in melting point, and an increase in degree of crystallization 7,8,13,15 . In this study, a decrease in average molecular weight and an increase in degree of crystallization also occurred over time, indicating on increase in hydrolytic degradation and embrittlement.…”

Section: Discussionmentioning

confidence: 99%

“…Some have evaluated the stability of bone segments after employment of PLLA in oral and maxillofacial surgery 1,17,18 . Others have evaluated the dynamic and chemical properties of these materials 2,8,13 , or changes in their physical properties with hydrolytic degradation 7,8,13,15 .…”

Section: Introductionmentioning

confidence: 99%

“…Some found that PLLA retains about 80% of its original bending strength for 12 weeks after hydrolytic degradation sets in, quickly decreasing in strength thereafter 7,8,13,15 .…”

Section: Introductionmentioning

confidence: 99%

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Changes in mechanical properties of poly-l-lactic acid mini-plate under functional load simulating sagittal splitting ramus osteotomy

Mizuhashi

Suga

Uchiyama

et al. 2008

International Journal of Oral and Maxillofacial Surgery

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The purpose of this study was to investigate how the characteristics of a poly-L-lactic acid mini-plate changed with dynamic loading in an environment with hydrolytic degradation.We prepared a mandible osteosynthesis model with specimen poly-L-lactic acid mini-plates to simulate sagittal splitting ramus osteotomy. The model was then subjected to dynamic loading, and changes in specimen shape and surface quality were observed. Specimen bending strength was then measured, and degree of hydrolytic degradation estimated. Statistical studies included an analysis of variance (ANOVA).Neither dynamic loading nor degree of load clearly affected degree of hydrolytic degradation. The specimens maintained their original shape and bending strength for up to 4 weeks with dynamic loading of 40 N or less in an environment with hydrolytic degradation. However, at 8 weeks, under the same conditions, the specimens showed cracks or fractures, or both, together with a clear decrease in bending strength.The results suggest that dynamic loading causes cracking in a poly-L-lactic acid mini-plate, and that growth of those cracks decreases bending strength over time, leading to fatigue fracture.--2

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Changes in mechanical properties of poly-l-lactic acid mini-plate under functional load simulating sagittal splitting ramus osteotomy

Mizuhashi

Suga

Uchiyama

et al. 2008

International Journal of Oral and Maxillofacial Surgery

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“…It is well-known that crystalline regions in the polymer structure are highly resistant to hydrolytic degradation in regard to amorphous regions. Thus, the degradation and reabsorption rates of the homopolymers are relatively slow due to their high crystallinity [25][26][27]. In order to reduce the crystallinity of PLLA or PDLA, accelerate the degradation rate and avoid the formation of highly-resistant crystalline fragments, the copolymerization of L- PLAs obtained by ring-opening polymerization (ROP) are the most commonly studied examples due to the possibility of an accurate control of the chemistry and production of high molecular weight polymers, compared to the other polymerization strategy (polycondensation).…”

Section: Polylactide and Its Copolyesters: Towards Tunable Mechanicalmentioning

confidence: 99%

Poly(α-hydroxy Acids)-Based Cell Microcarriers

Larrañaga

Sarasua

2016

Applied Sciences

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Biodegradable poly(α-hydroxyacids) have gained increasing interest in the biomedical field for their use as cell microcarriers thanks to their biodegradability, biocompatibility, tunable mechanical properties/degradation rates and processability. The synthesis of these poly(α-hydroxyacids) can be finely controlled to yield (co)polymers of desired mechanical properties and degradation rates. On the other hand, by simple emulsion-solvent evaporation techniques, microspheres of controlled size and size distribution can be fabricated. The resulting microspheres can be further surface-modified to enhance cell adhesion and proliferation. As a result of this process, biodegradable microcarriers with advanced functionalities and surface properties that can be directly employed as injectable cell microcarriers are obtained.

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“…It can be seen that the PLLA degrades by hydrolysis through the presence of esters where scissions take place. In the crystallized PLLA materials the chains in the amorphous regions are predominantly hydrolysed (180,181). However, an increase of the elastic modulus is observed for the scaffolds with filler immersed 14 and 21 days in SBF.…”

Section: Effect Of the Filler Content On The Scaffold's Propertiesmentioning

confidence: 96%

Scaffold design and characterisation for osteochondral tissue regeneration

Deplaine¹

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In vitro hydrolysis of poly(l-lactide) crystalline residues as extended-chain crystallites. Part I: long-term hydrolysis in phosphate-buffered solution at 37°C

Cited by 86 publications

References 43 publications

Changes in mechanical properties of poly-l-lactic acid mini-plate under functional load simulating sagittal splitting ramus osteotomy

Changes in mechanical properties of poly-l-lactic acid mini-plate under functional load simulating sagittal splitting ramus osteotomy

Poly(α-hydroxy Acids)-Based Cell Microcarriers

Scaffold design and characterisation for osteochondral tissue regeneration

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