In-vitro heat-generating and apatite-forming abilities of PMMA bone cement containing TiO2 and Fe3O4

Kubota, Moe; Yokoi, Taishi; Ogawa, Tomoyuki; Saito, Shin; Furuya, Maiko; Yokota, Katsushi; Kanetaka, Hiroyasu; Jeyadevan, Balachandran; Kawashita, Masakazu

doi:10.1016/j.ceramint.2021.01.080

Cited by 16 publications

(9 citation statements)

References 25 publications

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“…Besides, PSF is biocompatible and has been used for bio-related applications such as bone prosthetic material in orthopedics and implants, with promising results in animal models [22] or in dentistry applications [23]. However, in certain cases, polysulfone by itself cannot accomplish some mechanical, aesthetic, and optical properties that allow it to be an adequate substitute for bone-like tissues; therefore, its modification by the addition of fillers may be a good solution [24].…”

Section: Introductionmentioning

confidence: 99%

Airbrushed Polysulfone (PSF)/Hydroxyapatite (HA) Nanocomposites: Effect of the Presence of Nanoparticles on Mechanical Behavior

2022

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Nanocomposite films of polysulfone (PSF)—hydroxyapatite (HA) were prepared with a commercial airbrush. Structural, thermal, and mechanical characterization allows obtaining new information to understand the role of the nanofiller–polymer matrix interphase in the final performance of these materials in relation to its possible applications in the restoration of bones. Fourier-transform infrared spectroscopy shows that there are hardly any structural changes in the polymer when adding HA particles. From thermal analysis (differential scanning calorimetry and thermogravimetry), it can be highlighted that the presence of HA does not significantly affect the glass transition temperature of the PSF but decelerates its thermal degradation. All this information points out that any change in the PSF performance because of the addition of HA particles cannot be due to specific interactions between the filler and the polymer. Results obtained from uniaxial tensile tests indicate that the addition of small amounts of HA particles (1% wt) leads to elastic moduli higher than the upper bound predicted by the rule of mixtures suggesting there must be a high contribution of the interphase. A simple model of the nanocomposite is proposed for which three contributions must be considered, particles, interphase and matrix, in such a way that interphases arising from different particles can interact by combining with each other thus leading to a decrease in its global contribution when the amount of particles is high enough. The mechanical behavior can be explained considering a balance between the contribution of the interphase and the number of particles. Finally, a particular mechanism is proposed to explain why in certain nanocomposites relatively high concentrations of nanoparticles may substantially increase the strain to failure.

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Section: Introductionmentioning

confidence: 99%

Airbrushed Polysulfone (PSF)/Hydroxyapatite (HA) Nanocomposites: Effect of the Presence of Nanoparticles on Mechanical Behavior

2022

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“…Therefore, different additions to the base material were proposed as discussed below. Besides, to improve the effectiveness of the treatment for bone defects caused by metastatic bone tumors, the formulation of PMMA cement containing titania and magnetite that offers high bone affinity, making the cement suitable for use in magnetic hyperthermia, was developed [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of Different Nanometals Implemented in PMMA Bone Cement on Biological and Mechanical Properties

et al. 2022

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Cemented arthroplasty is a common process to fix prostheses when a patient becomes older and his/her bone quality deteriorates. The applied cements are biocompatible, can transfer loads, and dampen vibrations, but do not provide antibacterial protection. The present work is aimed at the development of cement with antibacterial effectivity achieved with the implementation of nanoparticles of different metals. The powders of Ag, Cu with particles size in a range of 10–30 nm (Cu10) and 70–100 nm (Cu70), AgCu, and Ni were added to PMMA cement. Their influence on compression strength, wettability, and antibacterial properties of cement was assessed. The surface topography of samples was examined with biological and scanning electron microscopy. The mechanical properties were determined by compression tests. A contact angle was observed with a goniometer. The biological tests included an assessment of cytotoxicity (XTT test on human cells Saos-2 line) and bacteria viability exposure (6 months). The cements with Ag and Cu nanopowders were free of bacteria. For AgCu and Ni nanoparticles, the bacterial solution became denser over time and, after 6 months, the bacteria clustered into conglomerates, creating a biofilm. All metal powders in their native form in direct contact reduce the number of eukaryotic cells. Cell viability is the least limited by Ag and Cu particles of smaller size. All samples demonstrated hydrophobic nature in the wettability test. The mechanical strength was not significantly affected by the additions of metal powders. The nanometal particles incorporated in PMMA-based bone cement can introduce long-term resistance against bacteria, not resulting in any serious deterioration of compression strength.

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“…In this study, two cement samples of F25T15-3/2-42 and F30T15-3/2-42 were subjected to SEM and TF-XRD analyses as shown in Figure 2, since we confirmed that these samples show both heat-generating ability and apatiteforming ability in our previous studies. 25,26 The surface morphology of the samples was very similar when observed using SEM, as shown in Figure 2(a). The TF-XRD peaks ascribed to TiO 2 (rutile and anatase) and Fe 3 O 4 (magnetite) were clearly observed for cement samples F25T15-3/2-42 and F30T15-3/2-42 (Figure 2(b)), and they were almost identical to powder XRD peaks of original Fe 3 O 4 and TiO 2 powders.…”

Section: Resultsmentioning

confidence: 61%

“…In previous studies, we prepared PMMA-type cements containing 20-45 mass% of Fe 3 O 4 and TiO 2 and evaluated their setting behavior, mechanical properties, apatiteforming ability, and heat-generation characteristics. 25,26 The results revealed that as the content of Fe 3 O 4 and TiO 2 increases, the setting time increases while the maximum temperature decreases. Further, the compressive strength of the PMMA cement containing 20-45 mass% of Fe 3 O 4 and TiO 2 satisfied the ISO5833 standard (>70 MPa).…”

Section: Introductionmentioning

confidence: 99%

Proliferation and differentiation of MC3T3‐E1 cells on polymethyl methacrylate cements containing Fe₃O₄ and TiO₂ for hyperthermic treatment of metastatic bone tumors

Kubota,

Furuya,

Yokota

et al. 2023

J Biomater Appl

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Polymethyl methacrylate (PMMA) bone cement is widely used to relieve pain caused by metastatic bone tumors. We previously found that PMMA bone cement containing 15 mass% or more of TiO2 showed good apatite-forming ability, and 25 mass% or more of Fe3O4 generated sufficient heat for hyperthermia under an alternating current (AC) magnetic field. In this study, the cytocompatibility of PMMA bone cement with Fe3O4:TiO2 weight ratios of 25:15 (F25T15-3/2-42) and 30:15 (F30T15-3/2-42) was evaluated using osteoblastic cells (MC3T3-E1). The proliferation and differentiation of MC3T3-E1 cells were suppressed for F25T15-3/2-42 and F30T15-3/2-42 compared to PMMA bone cement without Fe3O4 and TiO2 (F0T0-3/2-42). The release of methyl methacrylate (MMA) monomers from F25T15-3/2-42 and F30T15-3/2-42 at 7 days was about 33 and 50 times higher than that from F0T0-3/2-42, respectively. The remarkable release of MMA monomers from F25T15-3/2-42 and F30T15-3/2-42 may be responsible for the suppressed proliferation and differentiation of MC3T3-E1 cells. The release of MMA monomers was not reduced when the MMA/PMMA weight ratio was decreased from 3/2 to 1/1, however, it was significantly reduced by increasing the content of benzoyl peroxide (BPO) and N, N-dimethyl- p-toluidine (DMPT) to 8 and 4 mass% against MMA, respectively. Proliferation and differentiation of MC3T3-E1 cells on PMMA-type cements containing Fe3O4 and TiO2 with increased BPO and DMPT contents need to be investigated in the future; however, our findings will be useful for designing PMMA cements for the hyperthermic treatment of metastatic bone tumors.

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In-vitro heat-generating and apatite-forming abilities of PMMA bone cement containing TiO2 and Fe3O4

Cited by 16 publications

References 25 publications

Airbrushed Polysulfone (PSF)/Hydroxyapatite (HA) Nanocomposites: Effect of the Presence of Nanoparticles on Mechanical Behavior

Airbrushed Polysulfone (PSF)/Hydroxyapatite (HA) Nanocomposites: Effect of the Presence of Nanoparticles on Mechanical Behavior

Influence of Different Nanometals Implemented in PMMA Bone Cement on Biological and Mechanical Properties

Proliferation and differentiation of MC3T3‐E1 cells on polymethyl methacrylate cements containing Fe₃O₄ and TiO₂ for hyperthermic treatment of metastatic bone tumors

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In-vitro heat-generating and apatite-forming abilities of PMMA bone cement containing TiO2 and Fe3O4

Cited by 16 publications

References 25 publications

Airbrushed Polysulfone (PSF)/Hydroxyapatite (HA) Nanocomposites: Effect of the Presence of Nanoparticles on Mechanical Behavior

Airbrushed Polysulfone (PSF)/Hydroxyapatite (HA) Nanocomposites: Effect of the Presence of Nanoparticles on Mechanical Behavior

Influence of Different Nanometals Implemented in PMMA Bone Cement on Biological and Mechanical Properties

Proliferation and differentiation of MC3T3‐E1 cells on polymethyl methacrylate cements containing Fe3O4 and TiO2 for hyperthermic treatment of metastatic bone tumors

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Product

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Proliferation and differentiation of MC3T3‐E1 cells on polymethyl methacrylate cements containing Fe₃O₄ and TiO₂ for hyperthermic treatment of metastatic bone tumors