In vitro genotoxicity of Melaleuca alternifolia essential oil in human lymphocytes

Pereira, Taís Susane; Sant’Anna, Juliane Rocha de; Silva, Expedito Leite; Pinheiro, Antônio Lelis; Castro-Prado, Marialba Avezum Alves de

doi:10.1016/j.jep.2013.11.045

Cited by 30 publications

(16 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The composition of EOs (Table 1) purchased from By Samia Aromaterapia are in agreement with those reported in literature, and the major compounds of M. alternifolia, P. graveolens and C. martinii essential oils are terpinen-4-ol, citronellol and geraniol, respectively (23)(24)(25)(26)(27)(28).…”

Section: Resultssupporting

confidence: 88%

The antibacterial effects ofMelaleuca alternifolia,Pelargonium graveolensandCymbopogon martiniiessential oils and major compounds on liquid and vapor phase

Andrade

Barbosa

Alves

et al. 2015

Journal of Essential Oil Research

View full text Add to dashboard Cite

without requiring direct contact, and ease of application (11), in a addition, EO vapors could be used in the disinfecting air process (12). However, in fumigation processes with medical purposes, the efficacy and safety of EOs in their gaseous state should be checked, although their antimicrobial and cytotoxicity activities have been measured in their liquid phase. Thus, standard procedures for evaluating their antimicrobial activities in liquid phase have already been established, while few studies with EOs at vapor phase have been performed (13). Infectious diseases constitute a worldwide problem, and bacterial controls are usually by disinfection with liquid disinfectants. However, liquid disinfectants have an antibacterial effect in topical use (e.g., liquid phenol disinfectants) and aseptic environments, such as surgical rooms, clinical and food microbiology laboratories and the pharmaceutical industry require special attention (14). Community and nosocomial pathogens, including Staphylococcus aureus, Salmonella, Enterococcus sp.,

show abstract

Section: Resultssupporting

confidence: 88%

The antibacterial effects ofMelaleuca alternifolia,Pelargonium graveolensandCymbopogon martiniiessential oils and major compounds on liquid and vapor phase

Andrade

Barbosa

Alves

et al. 2015

Journal of Essential Oil Research

View full text Add to dashboard Cite

show abstract

“…The oil was obtained by the steam distillation technique. The oil sample contained the following major components: terpinen-4-ol (42.8%), γ-terpinene (20.4%), p -cymene (9.6%), α-terpinene (7.9%), 1,8-cineole (3%), α-terpineol (2,8%) and α-pinene (2.4%) as determined by gas chromatography mass spectrometry [ 21 ].…”

Section: Methodsmentioning

confidence: 99%

Essential oil of Melaleuca alternifolia for the treatment of oral candidiasis induced in an immunosuppressed mouse model

Rasteiro

Costa

Araújo

et al. 2014

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundThe search for alternative therapies for oral candidiasis is a necessity and the use of medicinal plants seems to be one of the promising solutions. The objective of this study was to evaluate the in vitro and in vivo effects of the essential oil of Melaleuca alternifolia on Candida albicans.MethodsThe minimum inhibitory concentration (MIC) and minimum biofilm eradication concentration (MBEC) of M. alternifolia were determined by the broth microdilution assay. For the in vivo study, twelve immunosuppressed mice with buccal candidiasis received topical applications of M. alternifolia with MBEC. After treatment, yeasts were recovered from the mice and quantified (CFU/mL). Mice were killed for morphologic analysis of the tongue dorsum by optical and scanning electron microscopy. Data were analyzed using Student’s t test or Mann-Whitney test.ResultsThe MIC of M. alternifolia was 0.195% and the MBEC was 12.5%. Treatment with M. alternifolia achieved a 5.33 log reduction in C. albicans and reduced the microscopic lesions of candidiasis.ConclusionsM. alternifolia oil at a 12.5% was effective to eradicate a C. albicans biofilm formed in vitro and to reduce yeasts of C. albicans in an immunosuppressed mouse model.

show abstract

“…Its composition shows terpinen-4-ol, γ-terpinene, p -cymene, α-terpinene, 1,8-cineole, α-terpineol, and α-pinene. [ 27 ]…”

Section: Methodsmentioning

confidence: 99%

Essential oils, their therapeutic properties, and implication in dentistry: A review

Dagli

Mahmoud

et al. 2015

J Int Soc Prevent Communit Dent

122

View full text Add to dashboard Cite

Background:Antibacterial treatments currently used for treatment cause several side effects, and bacterial resistance to the antibiotics is also increasing. Therefore, there is need to find better alternatives. Essential oils (EOs) have been used for treatment of various ailments since ancient times and have gained popularity over the years. Safety and efficacy of EOs have been proved by several clinical trials. This review gives an overview on the EOs, their uses, and adverse effects.Materials and Methods:A literature search was performed in the PubMed for clinical trial studies and review articles on EOs published up to February 2015. The search was performed during March 2015. The following keywords were used: “Lavender essential oil,” “cinnamon oil,” “clove oil,” “eucalyptus oil,” “peppermint oil,” “lemon EOs,” and “tea tree oil.”Results:Total 70 relevant articles were found in PubMed database. After screening of abstracts, 52 articles were selected to be included in the present review.Conclusion:On the basis of the available information, it can be concluded that EOs have the potential to be developed as preventive or therapeutic agents for various oral diseases, but further clinical trials are required to establish their safety and efficacy.

show abstract

In vitro genotoxicity of Melaleuca alternifolia essential oil in human lymphocytes

Abstract: Results demonstrate that TTO, in the tested concentrations, is not genotoxic in in vitro mammalian cells.

Cited by 30 publications

References 29 publications

The antibacterial effects ofMelaleuca alternifolia,Pelargonium graveolensandCymbopogon martiniiessential oils and major compounds on liquid and vapor phase

The antibacterial effects ofMelaleuca alternifolia,Pelargonium graveolensandCymbopogon martiniiessential oils and major compounds on liquid and vapor phase

Essential oil of Melaleuca alternifolia for the treatment of oral candidiasis induced in an immunosuppressed mouse model

Essential oils, their therapeutic properties, and implication in dentistry: A review

Contact Info

Product

Resources

About