In vitro genotoxicity of dimethyl terephthalate

Monarca, Silvano; Pool‐Zobel, Beatrice L.; Rizzi, R.; Klein, Philipp; Schmezer, Peter; Piatti, E.; Pasquini, Rossana; Fusco, R. De; Biscardi, D

doi:10.1016/0165-7992(91)90112-h

Cited by 12 publications

(3 citation statements)

References 22 publications

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“…Undifferentiated HepaRG human hepatoma cell line (HPR101) was obtained from Biopredic International (Saint Grégoire, France). Cells were (David et al, 2018;Dertinger et al, 2012;Habas et al, 2017;Kirkland et al, 2016;Le Hegarat et al, 2014;Seo et al, 2019;Seo et al, 2020;Bemis et al, 2018 (Habas et al, 2017;Liu et al, 2019;Kirkland et al, 2016;Seo et al, 2019;Seo et al, 2020;Dertinger et al, 2012;Bemis et al (Le Hegarat et al, 2014;Severin et al, 2005;Seo et al, 2019;Seo et al, 2020;Kirkland et al, 2016;Guo et al, 2020) 2 (Fowler et al, 2012;Eichenbaum et al, 2009;Hartmann and Speit, 1997;Hu et al, 2009;NTP, 1993) Ethyl (Monarca et al, 1991;Goncharova et al, 1988;Shelby et al, 1993 (Nohmi, 2018;Morita et al, 2016;Ding et al, 2015;Martins et al, 2012;Schulte-Hubbert et al, 2020;Muller et al, 1994;Villarini et al, 2014 cultured and differentiated at 37 °C in a humidified atmosphere with 5% CO2 according to the supplier's protocol with minor modifications. Briefly, 0.65-0.7 million undifferentiated HepaRG cells were seeded in a 100-mm tissue culture dish and cultured in 10 ml growth medium for 14 days.…”

Section: Cell Culturementioning

confidence: 99%

Evaluation of an in vitro three-dimensional HepaRG spheroid model for genotoxicity testing using the high-throughput CometChip platform

Seo

Muskhelishvili³

et al. 2022

ALTEX

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Section: Cell Culturementioning

confidence: 99%

Evaluation of an in vitro three-dimensional HepaRG spheroid model for genotoxicity testing using the high-throughput CometChip platform

Seo

Muskhelishvili³

et al. 2022

ALTEX

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“…DMSO was used as the solvent in that study, a fact that might possibly have contributed to the difference in results. This chemical was reported to be negative in four in vitro genetic toxicity assays by Tennant et al [1987] and, more recently in a larger battery of in vitro genetic toxicity tests by Monarca et al [1991].…”

Section: Dimethyl Terephthalate (Nc) Negativementioning

confidence: 99%

Evaluation of a three‐exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals

Shelby

Erexson

Hook

et al. 1993

Environ and Mol Mutagen

250

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Forty-nine chemicals were tested in a mouse bone marrow micronucleus test that employed three daily exposures by intraperitoneal injection. Bone marrow samples were obtained 24 hr following the final exposure. Twenty-five rodent carcinogens and 24 noncarcinogens were selected randomly from the 44 carcinogens and 29 noncarcinogens used by Tennant et al. (Science 236:933-941, 1987) to evaluate the performance of four in vitro genetic toxicity tests. As in that study of in vitro tests, the micronucleus tests were conducted with coded chemicals and test results (positive or negative) were determined prior to decoding. This study was conducted as part of an effort to assess the ability of the micronucleus test to discriminate between rodent carcinogens and noncarcinogens and to determine its potential role, in combination with other short-term tests, in identifying genotoxic chemicals that present a carcinogenic hazard. Nine chemicals were judged to be positive in the micronucleus test. This relatively low number of positive results, along with published and unpublished results from rodent micronucleus and chromosome aberration assays on several of these 49 chemicals, contributed to the conclusion that a single micronucleus test protocol is not adequate to detect all chemicals capable of inducing chromosomal damage in the bone marrow. However, a combination of two relatively simple assays such as the Salmonella and micronucleus tests can provide important information on the genetic toxicity of test chemicals and may provide guidance on the need for and the nature and extent of future toxicity studies.

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“…Due to its high demand and utilization, detection of this class of chemicals and its derivatives in the ambient environments has been well documented (Giam et al 1978;Peterson and Freeman 1982). Its potential impact on the living organisms of the ecosystem prompted toxicological investigations to elucidate its effects on animals (Krasavage et al 1973;Goud et al 1990; Monarca et al 1991;Sivamurthy et al 1991;Shah et al 1998;Rahman et al 2003;Mahood et al 2005). DMTP has been implicated to a number of symptoms including irritation of skin, eyes and respiratory tract, skin rash, tearing and blurred vision in human (Rahman et al 2003).…”

Section: Introductionmentioning

confidence: 98%

Degradability of dimethyl terephthalate by Variovorax paradoxus T4 and Sphingomonas yanoikuyae DOS01 isolated from deep-ocean sediments

Wang

2006

Ecotoxicology

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Two strains of bacteria were isolated from deep-ocean sediments of the South China Sea using enrichment culturing technique and they were identified as Sphingomonas yanoikuyae DOS01 (AY878409) and Variovorax paradoxus T4 (AY878410) based on 16S rRNA gene sequences. S. yanoikuyae DOS01 was only capable of transforming dimethyl terephthalate (DMTP) to monomethyl terephthalate (MMTP) without further degradation while V. paradoxus T4 exhibited ability in mineralizing DMTP as the sole source of carbon and energy. The biochemical pathway of DMTP degradation was through MMTP and terephthalic acid (TA) as major detectable degradation intermediates in the culture media by both microorganisms. V. paradoxus T4 utilized DMTP and MMTP via hydrolysis of diester and monoester in the initial steps in degradation as confirmed by total organic carbon analysis of the culture medium and esterase activity assay of the lysed cells and fraction. The specific hydrolysis activity of esterase induced by DMTP or MMTP showed that greater hydrolysis of p-nitrophenyl acetate by esterase induced by DMTP-grown cells than that induced by MMTP. Results of this research suggest that the cleavage of the two identical carboxylic ester groups of phthalate diester are carried out by highly specific esterases of the same bacteria in the environment.

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In vitro genotoxicity of dimethyl terephthalate

Cited by 12 publications

References 22 publications

Evaluation of an in vitro three-dimensional HepaRG spheroid model for genotoxicity testing using the high-throughput CometChip platform

Evaluation of an in vitro three-dimensional HepaRG spheroid model for genotoxicity testing using the high-throughput CometChip platform

Evaluation of a three‐exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals

Degradability of dimethyl terephthalate by Variovorax paradoxus T4 and Sphingomonas yanoikuyae DOS01 isolated from deep-ocean sediments

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