in vitro genotoxic and mutagenic evaluation of the aqueous extract of Codiaeum variegatum and its amoebicidal sub-fraction

Njoya, Emmanuel Mfotie; Moundipa, Paul Fewou; Stopper, Helga

doi:10.1016/j.jep.2014.06.038

Cited by 8 publications

(1 citation statement)

References 23 publications

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“…Our COMET assay showed that the plant extract did not cause any deleterious effect on the cell DNA. Previous studies assessing the genotoxicity of medicinal plants showed great variability in their genotoxic potential, depending on the plants and types of extracts tested [45,46,47,48]. We demonstrated that P. mauritianum did not exert a high cytotoxicity regardless of the cell lines tested.…”

Section: Discussionmentioning

confidence: 52%

The Polyphenol-Rich Extract from Psiloxylon mauritianum, an Endemic Medicinal Plant from Reunion Island, Inhibits the Early Stages of Dengue and Zika Virus Infection

Clain

Haddad

Koishi

et al. 2019

IJMS

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The recent emergence and re-emergence of viral infections transmitted by vectors, such as the Zika virus (ZIKV) and Dengue virus (DENV), is a cause for international concern. These highly pathogenic arboviruses represent a serious health burden in tropical and subtropical areas of the world. Despite the high morbidity and mortality associated with these viral infections, antiviral therapies are missing. Medicinal plants have been widely used to treat various infectious diseases since millenaries. Several compounds extracted from plants exhibit potent effects against viruses in vitro, calling for further investigations regarding their efficacy as antiviral drugs. Here, we demonstrate that an extract from Psiloxylon mauritianum, an endemic medicinal plant from Reunion Island, inhibits the infection of ZIKV in vitro without exhibiting cytotoxic effects. The extract was active against different ZIKV African and Asian strains, including an epidemic one. Time-of-drug-addition assays revealed that the P. mauritianum extract interfered with the attachment of the viral particles to the host cells. Importantly, the P. mauritianum extract was also able to prevent the infection of human cells by four dengue virus serotypes. Due to its potency and ability to target ZIKV and DENV particles, P. mauritianum may be of value for identifying and characterizing antiviral compounds to fight medically-important flaviviruses.

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