In vitro Generated Megakaryocytes for the Detection of Human Platelet Antigen-Specific Alloantibodies
Günalp Uzun,
Josip Lucic,
Irene Marini
et al.
Abstract:<b><i>Introduction:</i></b> Serologic characterization of antihuman platelet antigen (HPA) alloantibodies is crucial in fetal neonatal alloimmune thrombocytopenia. The gold standard MAIPA assay requires fresh platelets from HPA-genotyped donors, which is challenging for some laboratories. Megakaryocytes express HPA epitopes and offer an alternative source for detecting anti-HPA antibodies. The objective of this study was to assess the efficacy of a novel assay called monoclonal antibody… Show more
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