In vitro flow investigations in the aortic arch during cardiopulmonary bypass with stereo-PIV

Büsen, Martin; Kaufmann, Tim; Neidlin, Michael; Steinseifer, Ulrich; Sonntag, Simon J.

doi:10.1016/j.jbiomech.2015.03.030

Cited by 23 publications

(6 citation statements)

References 29 publications

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“…The circulating fluid was a solution of 42% water and 58% glycerol to match the refractive index of the silicone model (n = 1.41) while keeping a density of 1.14 g/cm 3 and a dynamic viscosity of 0.01017 Pa•s at room temperature. Index matching is required for the PIV techniques to achieve optical transparency, minimizing errors due to the optical distortions of the model and the liquid interface.…”

Section: Continuous Flow-mentioning

confidence: 99%

“…5,6 Recently, PIV has been applied to biomedical applications to capture physiological and pathological flows in multiple cardiovascular areas such as heart valves, aneurysms and vascular stenosis. 3,9,11,13,16 PIV can assess complex velocities in entire flow fields with up to 4 Mpixel resolution and hundreds of frames per second. There are currently three PIV techniques that are appropriate for comparative velocity measurements: 2D PIV, stereoscopic PIV (stereo-PIV) and tomographic PIV (tomo-PIV).…”

Section: Introductionmentioning

confidence: 99%

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Comparison of 4D Flow MRI and Particle Image Velocimetry Using an In Vitro Carotid Bifurcation Model

2018

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Four-dimensional (4D) Flow magnetic resonance imaging (MRI) enables the acquisition and assessment of complex hemodynamics in vivo from different vascular territories. This study investigated the viability of stereoscopic and tomographic particle image velocimetry (stereo- and tomo-PIV, respectively) as experimental validation techniques for 4D Flow MRI. The experiments were performed using continuous and pulsatile flows through an idealized carotid artery bifurcation model. Transverse and longitudinal planes were extracted from the acquired velocity data sets at different regions of interest and were analyzed with a point-by-point comparison. An overall root-mean-square error (RMSE) was calculated resulting in errors as low as 0.06 and 0.03 m/s when comparing 4D Flow MRI with stereo- and tomo-PIV, respectively. Quantitative agreement between techniques was determined by evaluating the relationship for individual velocity components and their magnitudes. These resulted in correlation coefficients (R) of 4D Flow MRI with stereo- and tomo-PIV, as low as 0.76 and 0.73, respectively. The 3D velocity measurements from PIV showed qualitative agreement when compared to 4D Flow MRI, especially with tomo-PIV due to the addition of volumetric velocity measurements. These results suggest that tomo-PIV can be used as a validation technique for 4D Flow MRI, serving as the basis for future validation protocols.

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Section: Continuous Flow-mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of 4D Flow MRI and Particle Image Velocimetry Using an In Vitro Carotid Bifurcation Model

2018

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“…After the fabrication process, in vitro velocity fields of blood flow can be measured using several techniques [18,30,[35][36][37][38][39]. However, in the present study, blood flow measurements and visualizations were performed using a high-speed video microscopy system.…”

Section: Introductionmentioning

confidence: 99%

3D Printed Biomodels for Flow Visualization in Stenotic Vessels: An Experimental and Numerical Study

Carvalho

Rodrigues

Ribeiro³

et al. 2020

Micromachines

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Atherosclerosis is one of the most serious and common forms of cardiovascular disease and a major cause of death and disability worldwide. It is a multifactorial and complex disease that promoted several hemodynamic studies. Although in vivo studies more accurately represent the physiological conditions, in vitro experiments more reliably control several physiological variables and most adequately validate numerical flow studies. Here, a hemodynamic study in idealized stenotic and healthy coronary arteries is presented by applying both numerical and in vitro approaches through computational fluid dynamics simulations and a high-speed video microscopy technique, respectively. By means of stereolithography 3D printing technology, biomodels with three different resolutions were used to perform experimental flow studies. The results showed that the biomodel printed with a resolution of 50 μm was able to most accurately visualize flow due to its lowest roughness values (Ra = 1.8 μm). The flow experimental results showed a qualitatively good agreement with the blood flow numerical data, providing a clear observation of recirculation regions when the diameter reduction reached 60%.

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“…In addition, recent advances in 3D modeling and printing techniques facilitate the fabrication of patient-specific flow phantoms. While in vivo studies do not predict hemodynamic changes due to various vascular modifications, vascular flow phantoms facilitate in-depth fluid-dynamic experiments with various modifications for vascular geometries1516.…”

mentioning

confidence: 99%

The influence of the aortic valve angle on the hemodynamic features of the thoracic aorta

Kim

Kweon

et al. 2016

Sci Rep

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Since the first observation of a helical flow pattern in aortic blood flow, the existence of helical blood flow has been found to be associated with various pathological conditions such as bicuspid aortic valve, aortic stenosis, and aortic dilatation. However, an understanding of the development of helical blood flow and its clinical implications are still lacking. In our present study, we hypothesized that the direction and angle of aortic inflow can influence helical flow patterns and related hemodynamic features in the thoracic aorta. Therefore, we investigated the hemodynamic features in the thoracic aorta and various aortic inflow angles using patient-specific vascular phantoms that were generated using a 3D printer and time-resolved, 3D, phase-contrast magnetic resonance imaging (PC-MRI). The results show that the rotational direction and strength of helical blood flow in the thoracic aorta largely vary according to the inflow direction of the aorta, and a higher helical velocity results in higher wall shear stress distributions. In addition, right-handed rotational flow conditions with higher rotational velocities imply a larger total kinetic energy than left-handed rotational flow conditions with lower rotational velocities.

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In vitro flow investigations in the aortic arch during cardiopulmonary bypass with stereo-PIV

Cited by 23 publications

References 29 publications

Comparison of 4D Flow MRI and Particle Image Velocimetry Using an In Vitro Carotid Bifurcation Model

Comparison of 4D Flow MRI and Particle Image Velocimetry Using an In Vitro Carotid Bifurcation Model

3D Printed Biomodels for Flow Visualization in Stenotic Vessels: An Experimental and Numerical Study

The influence of the aortic valve angle on the hemodynamic features of the thoracic aorta

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