In vitro Fertilization with Single-nucleotide Polymorphism Microarray-based Preimplantation Genetic Testing for Aneuploidy Significantly Improves Clinical Outcomes in Infertile Women with Recurrent Pregnancy Loss: A Randomized Controlled Trial

Preimplantation Genetic Testing for Aneuploidy With Comprehensive Chromosome Screening in Patients Undergoing In Vitro Fertilization

“…The search resulted in 9,373 hits. After screening titles, abstracts, and full texts, a total of nine studies 19,28,[30][31][32][33][34][35][36] with 3,334 participants met all inclusion criteria and were included in this systematic review (Fig. 1).…”

“…In another large trial, 19 live birth was defined as a live birth at 28 or more weeks of gestation after transfers of all euploid embryos. In four other trials, 28,31,33,36 live birth was not clearly defined (Appendix 2, available online at http://links.lww.com/AOG/C885). Rates of aneuploidy diagnosed by PGT-A are shown in Appendix 3, available online at http://links.lww.com/AOG/C885.…”

“…In this review, we included only randomized controlled trials and only those that used PGT-A with comprehensive chromosome screening. We included two recent trials, 19,36 accounting for 42.6% (1,419/ 3,334) of the total number of participants.…”

The Effects of Preimplantation Genetic Testing for Aneuploidy (PGT-A) on Patient-Important Outcomes in Embryo Transfer Cases: A Meta-Analysis

“…The study selection process and reasons for exclusion are summarized in figure 1 . Most studies included patients with good prognosis with overall ages ranging from 25 to 42 years ( 8 , 16 , 33 – 40 ).…”

“…The technologies used for PGT-A included array-based comparative genomic hybridization (aCGH) in four studies ( 33 , 36 , 38 , 39 ), next generation sequencing (NGS) in three studies, ( 34 , 35 , 37 ) real-time quantitative polymerase chain reaction (qPCR) in two studies, ( 8 , 16 ) and single nucleotide polymorphism (SNP)-based microarray in one study ( 40 ). Most of the authors reported performing frozen/thawed embryo transfer (FET) for both groups, except two studies where they reported a combination of fresh embryo transfer (ET) and FET ( 8 , 38 ).…”