In vitro fertilization with personalized blastocyst transfer versus frozen or fresh blastocyst transfer: a multicenter, randomized clinical trial

Abstract

EBL). Spearman's correlation was used to evaluate the correlation between leiomyomata volume and operative outcomes. Receiver-operator-characteristic (ROC) curves were constructed for outcomes showing statistical significance.RESULTS: A total of 117 patients were included; there was no difference in the demographics or leiomyomata characteristics of patients undergoing MRI or US in the AM (n¼69), LM (n¼13) or RALM (n¼35) groups. The mean age and leiomyomata volume of patients undergoing LM was 36.7AE7.1 years and 152.1AE90.9 mL, respectively. The was a strong positive correlation between MRI leiomyomata volume and operating time (rho¼0.90; P<0.001) and leiomyomata weight (rho¼0.89; P¼0.02). Patients in the RALM group had a mean age and leiomyomata volume of 36.9AE4.1 years and 242.4AE136.1 mL, respectively. A significant positive correlation between MRI leiomyomata volume and operating time (rho¼0.83; P¼0.03) and leiomyomata weight (rho¼0.79; P¼0.01) was noted in the RM group as well. These correlations were non-significant in the LM and RALM groups when using US leiomyomata volume. MRI leiomyomata volume was also predictive of LM and RALM conversion to laparotomy (area-under-the-curve¼0.92).

Role of Endometrial Receptivity Array for Implantation failure in In-Vitro Fertilization &amp; Intracytoplasmic Sperm Injection

“…A total of 75% of our patient's ERA results showed that endometrium was found to be receptive which is comparable with the study of Patel et al 7 ERA helps finding out a personalized WOI for majority of these patients with previous implantation failure. In addition, the results of positive beta HCG in our 12 patients, as a marker of receptivity, are comparable to the study of Simon et al 12 and Mahajan et al 16 ERA test is accurate and sensitive in identifying genetic expressions of the endometrium to pinpoint embryo transfer timing. 19,20 PET guided by ERA significantly improves pregnancy rates in patients with unexplained repeated implantation failure.…”

“…Total RNA is obtained from endometrial biopsy and used for genomic expression to check receptivity. 12 ERA evaluates 238 genes expressed during WOI using RNA sequencing. 13 Following analysis, endometrium is classified as receptive or nonreceptive (NR).…”

The impact of an endometrial receptivity array on personalizing embryo transfer for patients with infertility: a meta-analysis

“…Hence, we suggested that blinding of participants in this circumstance was not applicable. When excluding the blinding criteria as in Figures 4 and 5 (11,16,26,27), the 2 studies of Simon et al (11,26) achieved a moderate level of quality. However, the remaining 2 RCTs still had a high risk of bias because of the incomplete data outcomes and lack of selective reporting (16,27).…”

“…The detailed characteristics of the included studies, such as the study design, country, year, patient characteristic, sample size, mean age, and primary outcome, are shown in Table 1 (26)(27)(28)(29)(30)(31)(32)(33). In general, the 17 studies (4 RCTs and 13 cohort studies) included data from 7,052 patients who underwent PET and standard embryo transfer (SET).…”

“…A summary of the quality assessment of the 4 RCTs is shown in Figures 2 and 3 (11,16,26,27). No study described the blinding of participants and outcomes, leading to a high risk of bias in all 4 RCTs.…”