In vitro fertilization increases the odds of gestational diabetes: a nationwide register-based cohort study

Vaajala, Matias; Liukkonen, Rasmus; Ponkilainen, Ville; Mattila, Ville M.; Kekki, Maiju; Kuitunen, Ilari

doi:10.1007/s00592-022-01975-z

Cited by 5 publications

(4 citation statements)

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“…The model was adjusted for covariates that were found to be risk factors for GDM based on the previous studies. The selected covariates included the following: maternal age, categorized maternal body mass index (BMI) using the WHO classification, maternal smoking status, IVF [ 4 ] and multiple pregnancies [ 5 ].…”

Section: Statisticsmentioning

confidence: 99%

Previous induced abortion or miscarriage is associated with increased odds for gestational diabetes: a nationwide register-based cohort study in Finland

et al. 2023

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Aims The aim of this study was to investigate the association between previous induced abortion or miscarriage and the development of gestational diabetes mellitus (GDM) using high-quality register data. Methods In this retrospective nationwide register-based cohort study, data from the national medical birth register (MBR) were used to evaluate the association between a history of miscarriage or induced abortion and GDM. We included all first pregnancies ending in delivery in which the oral glucose tolerance test was performed between 2004 and 2018. A logistic regression model was used to assess the development of GDM in the first pregnancy ending in delivery. Adjusted odds ratios (aOR) with 95% confidence intervals (Cis) were compared between groups. Results In total, 15,873 nulliparous women with a history of induced abortions, 22,337 with a history of miscarriages and 3594 with a history of both were found. The reference group consisted of 138,869 women without a history of induced abortions or miscarriages. Women with a history of induced abortions (24.7%, aOR 1.15 [CI 1.11–1.20]), a history of miscarriages (24.8%, aOR 1.14 [CI 1.10–1.18]) and a history of both (27.7% aOR 1.18 [CI 1.09–1.28]) had higher odds for the development of GDM when compared to the reference group (20.8%). The odds for GDM increased along with the increasing number of previous induced abortions and miscarriages. Conclusion Women with a history of induced abortions or miscarriages had higher odds for GDM in their first pregnancy leading to birth. Knowledge of this association will be helpful in the prevention and screening of GDM.

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Section: Statisticsmentioning

confidence: 99%

Previous induced abortion or miscarriage is associated with increased odds for gestational diabetes: a nationwide register-based cohort study in Finland

et al. 2023

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“…The model was adjusted for covariates that were found to be risk factors for GDM based on the previous studies and these were included in our data. The selected covariates included the following: maternal age, continuous maternal body mass index (BMI; calculated as weight in kilograms divided by the square of height in meters), maternal smoking status, in vitro fertilization, and multiple pregnancies 6–10 . An α of 0.05 was used as the cut‐off for significance.…”

Section: Methodsmentioning

confidence: 99%

“…The selected covariates included the following: maternal age, continuous maternal body mass index (BMI; calculated as weight in kilograms divided by the square of height in meters), maternal smoking status, in vitro fertilization, and multiple pregnancies. [6][7][8][9][10] An α of 0.05 was used as the cut-off for significance. Statistical…”

Section: Statisticsmentioning

confidence: 99%

The association between interpregnancy interval and gestational diabetes mellitus: A nationwide register‐based study in Finland

Vaajala,

Liukkonen,

Tarkiainen

et al. 2024

Intl J Gynecology & Obste

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ObjectivePrevious results on the association between interpregnancy interval (IPI) and gestational diabetes mellitus (GDM) have been contradictory. Hence, the aim of this study was to examine the association between IPI and GDM using high‐quality nationwide register data.MethodsAll women with first and second pregnancies during our study period from the National Medical Birth Register during 2004–2018 were considered. A logistic regression model was used to assess the association between the length of the IPI and development of the GDM in the second pregnancy. Women were divided into three groups based on the length of the IPI: short IPI (0–11 months), normal IPI (12–47 months), and long IPI (48+ months). Adjusted odds ratios (aOR) with 95% CI were compared between the groups.ResultsA total of 47 078 women were included in the study. We found no evidence of difference when women with short IPI were compared with women with normal IPI (aOR 0.99, 95% CI 0.93–1.05). Women with long IPI had increased odds for the development of GDM when compared with women with normal IPI (aOR 1.28, 95% CI 1.19–1.38). In the logistic regression model for continuous IPI, the total odds for the development of GDM increased as the IPI increased (aOR 1.05 per year, 95% CI 1.03–1.06).ConclusionThe odds for the development of GDM increased as the IPI increased. This study's results serve as a clarion call for proactive measures in GDM prevention. Moreover, they advocate for intensified investigation into the underlying factors contributing to GDM among women with extended IPI. It is imperative that these insights inform both clinical practice and further research agendas, as we strive to safeguard maternal health and well‐being.

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“…IVF-achieved pregnancies are associated with a higher risk for both obstetric and perinatal complications compared to spontaneous pregnancies [ 1 , 2 ]. Although several studies have reported an increased prevalence of GDM among IVF pregnancies, further investigations are needed to determine the exact time for GDM screening and the management of GDM in IVF pregnancies [ 3 – 5 ].…”

Section: Introductionmentioning

confidence: 99%

Potential risk of gestational diabetes mellitus in females undergoing in vitro fertilization: a pilot study

Ghanem,

El Kassar,

Magdy

et al. 2024

Clin Diabetes Endocrinol

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Background Most of the cases of hyperglycemia during pregnancy are attributed to gestational diabetes mellitus (GDM) (75–90%). Women diagnosed with GDM are at an increased risk for complications during pregnancy and delivery. This observational prospective study aimed to investigate the potential risk of GDM among Egyptian females following in vitro fertilization (IVF) pregnancies compared to spontaneous pregnancies (SC). Methods This prospective cohort study included normoglycemic females without any history of dysglycemia before this conception. Subjects were divided according to the type of conception into two age and BMI-matched groups: (IVF group): 55 pregnant females conceived by IVF, and (SC group) spontaneous pregnancy: 55 pregnant females conceived spontaneously. A one-step oral glucose tolerance test (OGTT) was performed at gestational weeks 20 and 28 for all study subjects. Results The incidence of GDM was statistically significantly higher in the IVF group compared to the spontaneous pregnancy (SC) group (20 and 5.5%, respectively), p = 0.022 at week 28. On comparing the incidence of GDM on early screening at week 20 in both groups, the incidence of GDM in the IVF group was significantly higher (16.4%) compared to (3.6%) in the spontaneous pregnancy (SC) group, p = 0.026. Conclusions IVF may have an increased potential risk for GDM. Moreover, the diagnosis of GDM may occur early (week 20), highlighting the need for precise and early screening for GDM in IVF pregnancies.

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In vitro fertilization increases the odds of gestational diabetes: a nationwide register-based cohort study

Cited by 5 publications

References 5 publications

Previous induced abortion or miscarriage is associated with increased odds for gestational diabetes: a nationwide register-based cohort study in Finland

Previous induced abortion or miscarriage is associated with increased odds for gestational diabetes: a nationwide register-based cohort study in Finland

The association between interpregnancy interval and gestational diabetes mellitus: A nationwide register‐based study in Finland

Potential risk of gestational diabetes mellitus in females undergoing in vitro fertilization: a pilot study

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