In vitro fertilization and autoimmunity: Evidence from an observational study

Rosa, Roberta; Ferrero, S.; Cifani, Noemi; Ferri, Livia; Proietta, Maria; Diamanti, Andrea Picchianti; Porto, Flavia Del

doi:10.1016/j.ejogrb.2018.12.042

Cited by 7 publications

(8 citation statements)

References 21 publications

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“…The relationship between autoantibodies, with or without a systemic disease, with infertility and RM is not well established in the literature. Antithyroid antibodies (anti‐thyroglobulin and anti‐thyroperoxidase), antiphospholipid antibodies (anti‐cardiolipin, anti‐β2‐glycoprotein‐I, and lupus anticoagulant), antispermatozoa antibodies, anti‐endomysium, anti‐DNA, and antinuclear antibodies (ANA) are the most studied autoimmune markers, which are related to reproductive problems …”

Section: Introductionmentioning

confidence: 99%

Antinuclear antibodies and recurrent miscarriage: Systematic review and meta‐analysis

Cavalcante

Sarno

et al. 2019

American J Rep Immunol

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Studies have investigated the relationship between antinuclear antibodies (ANA) and recurrent miscarriage (RM). The objective of this paper is to evaluate the presence of ANA as a risk factor for spontaneous abortion in patients with RM. By considering the guidelines of Preferred Reporting Items for Systematic Reviews and Meta‐Analysis, the authors performed systematic review and meta‐analysis by searching the databases of PubMed/Medline and SCOPUS. Review Manager, Version 5.3 performed the statistical analysis. Binary variables were analyzed by odds ratio (ORs) and 95% confidence interval (CI). The subgroup analysis compared the effect of different ANA titers. The authors analyzed the ANA patterns of immunofluorescence staining. Seven case‐control studies were selected. The frequency of positive ANA was statistically higher in the RM group (20.6%, 288/1400) as compared to the control group (6.7%, 72/1080). The meta‐analysis of the positive ANA showed a statistical difference between the two groups (OR 3.30, 95% CI 1.41‐7.73; I2 = 87%, P = .006). Studies have revealed different frequencies of ANA patterns of immunofluorescence. This meta‐analysis suggested that positive ANA might increase the risk of RM. However, it was not possible to conclude which ANA pattern of immunofluorescence staining is more frequent in the RM group.

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Section: Introductionmentioning

confidence: 99%

Antinuclear antibodies and recurrent miscarriage: Systematic review and meta‐analysis

Cavalcante

Sarno

et al. 2019

American J Rep Immunol

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“…This agrees with the literature that reports a higher prevalence of aPL, in infertile women in comparison with 2% observed in the general population. 4,6,7,11,18,19 Moreover, we observed a high prevalence of patients fulfilling classification criteria for systemic autoimmune diseases. This suggests that the persistence of autoantibodies can identify a subset of infertile women affected by immune disorders targeting above all reproduction.…”

Section: Discussionmentioning

confidence: 80%

“…4,23 It has been reported that their prevalence is higher in infertile women, ranging from 10-30%. 4,6,7,11,18,19 Moreover, it has been demonstrated that aPL can affect oocyte and placental development, implantation, and endometrial receptivity potentially impairing reproduction from conception to delivery. [4][5][6]24,32 Accordingly, in our results, 31.25% of women with persistently positive aPL showed infertility as the sole obstetrical feature and about half of them also suffered from recurrent ART failures.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, recurrent very early miscarriages can represent the reason why a woman attends to ART later in life, when fertility is reduced. 10,11 Despite evaluation of aPL is strongly recommended in women with obstetrical pathology, no consensus was reached about their role in infertility. 4 Based on such premises, the aim of our study was to evaluate the behavior of aPL in a population of women affected by idiopathic infertility undergoing intra-cytoplasmic sperm injection (ICSI) and to assess pregnancy progress from implantation to delivery.…”

Section: Introductionmentioning

confidence: 99%

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Antiphospholipid antibodies and idiopathic infertility

Porto

Ferrero²,

Cifani

et al. 2022

Lupus

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Objective The aim of our study was to evaluate obstetric outcome of women affected by idiopathic infertility showing persistently positive antiphospholipid antibodies (aPL). Methods : From 2000 consecutive patients undergoing ART, we selected 151 (7.55%) clinical records of patients affected by idiopathic infertility undergoing ICSI and showing positive aPL. Results Persistently positive aPL were found in 64/151 (42.38%) of the patients: in 34/64 (53.12%) at medium/high titers (group A) and in 30/64 (46.87%) at low titers (group B). Primary or secondary antiphospholipid syndrome (APS) was diagnosed in 25% of the patients, whereas 37.5% women showed clinical and/or laboratory features suggestive of APS, but not fulfilling clinical or laboratory classification criteria. Idiopathic infertility was the sole symptom in 31.25%. In 55% of these infertile patients, a history of recurrent failures of assisted reproductive techniques (ART) was also observed. Eighty-eight percent (88.88%) of women became pregnant and 77.77% gave birth. During pregnancy, an increase of aPL values was observed in 29.41% women of group B. Conclusions A careful selection of patients allowed us to confirm that women affected by idiopathic infertility show a high prevalence of aPL, suggesting that these autoantibodies can also affect conception. Considering pregnancy complications and thrombotic risk related to ovarian stimulation, measuring aPL can represent a valid tool to identify among infertile women undergoing ART those at higher risk of pregnancy complications potentially life-threatening for mother and the fetus. In such patients, an accurate diagnosis and an adequate therapy are related to a better ART outcome.

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“…Several autoimmune factors have been implicated in influencing implantation failure. Recent studies have investigated the contribution of autoimmune factors in implantation in women undergoing in-vitro fertilization [5][6][7]. Antiphospholipid antibodies more frequently identified in women planing in-vitro fertilization; their presence appears to affect the outcome of live birth rates, miscarriage, or pregnancy [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

An Overview of Autoimmunity in Implantation Failure: A Literature Review

Berestoviy

Mahmood

Berestoviy³

et al. 2021

Wiad Lek

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The aim: This review was aimed to understand the role of different types of autoantibodies like antiphospholipid, antithyroid, antisperm, antinuclear, anti-ovarian autoantibodies and heat shock protein HSP 60 in the process of implantation in the normal way of conceiving and IVF and also to estimate that how the presence of these autoantibodies affect the normal pregnancy outcome. Materials and methods: This review process performed in the obstetrics and gynaecology postgraduate department, Bogomolets national medical university, Kyiv, Ukraine. It was a review of already published papers not to need the ethical board committee's approval. By following the literature review guidelines, this paper was written and searched for relevant studies regarding autoantibodies and implantation, published in medical literature till 2020 were included in this review process. The search is done for studies published till 2020 in the English language from the Medline database, including Google Scholar, PubMed, Web of Science and Cochrane library database. Conclusions: Our recent work found that the involvement of APA, ANA and/or ATA in recipients of oocyte donations did not affect their pregnancy outcomes. Some researchers did not give any clear conclusion about these risks, and some stated that the use of some immunodepressant agents could be useful to reduce the harmful effects of these autoantibodies associated with implantation failure. Each autoantibody has a different mechanism of action to create the pathological state, some have direct effect, and some indirectly impact implantation. In future, further high-quality studies need to be performed for better understanding.

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In vitro fertilization and autoimmunity: Evidence from an observational study

Cited by 7 publications

References 21 publications

Antinuclear antibodies and recurrent miscarriage: Systematic review and meta‐analysis

Antinuclear antibodies and recurrent miscarriage: Systematic review and meta‐analysis

Antiphospholipid antibodies and idiopathic infertility

An Overview of Autoimmunity in Implantation Failure: A Literature Review

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