In vitro fermentation behaviors of fucosylated chondroitin sulfate from Pearsonothuria graeffei by human gut microflora

Wei, Chaoyang; Liao, Ningbo; Zhang, Yu; Ye, Xingqian; Li, Shan; Hu, Yaqin; Liu, Donghong; Linhardt, Robert J.; Wang, Xin

doi:10.1016/j.ijbiomac.2017.04.036

Cited by 25 publications

(17 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, we found a significant increase in genera associated with SCFA-production including Anaerostipes, Lachnospira, and other uncultured Lachnospiraceae. Others have shown enrichment in butyrogenic bacteria associated with increased fecal butyrate after C enrichment [10,30]. Our data also suggest that several different pathways of butyrate production may be enriched in C disaccharide fermentation [43].…”

Section: Discussionsupporting

confidence: 70%

“…Finally, we found that Christensenella and Bifidobacteria were lower after the G&C treatment, although other studies have shown that these taxa are involved in GAG degradation [10,44] and that they play a beneficial role in human health [48]. Christensellaceae, a recently described family [49], often co-occurs with Methanobrevibacter [50] and together they produce SCFAs from GAGs, starch, chitin [51], and hemicellulose [52].…”

Section: Discussionmentioning

confidence: 62%

“…The study protocol was approved by the Fred Hutch Institutional Review Board, registered in ClinicalTrials.Gov (NCT03827161 and NCT03963323), and all participants provided written informed consent. metabolism of C in vitro [10][11][12]. Only one study was conducted in vivo, and found decreased trends in abundances of Staphylococcus, Enterococcus and Clostridium in OA patients after oral administration of G [13].…”

Section: Methodsmentioning

confidence: 99%

“…A few recent small-scale studies have evaluated G and/or C and the gut microbiome in humans and have reported changes in microbial abundances [9]. Three studies assessed fecal microbial metabolism of C in vitro [10][11][12]. Only one study was conducted in vivo, and found decreased trends in abundances of Staphylococcus, Enterococcus and Clostridium in OA patients after oral administration of G [13].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Modulation of Gut Microbiota by Glucosamine and Chondroitin in a Randomized, Double-Blind Pilot Trial in Humans

et al. 2019

View full text Add to dashboard Cite

Glucosamine and chondroitin (G&C), typically taken for joint pain, are among the most frequently used specialty supplements by US adults. More recently, G&C have been associated with lower incidence of colorectal cancer in human observational studies and reduced severity of experimentally-induced ulcerative colitis in rodents. However, little is known about their effects on colon-related physiology. G&C are poorly absorbed and therefore metabolized by gut microbiota. G&C have been associated with changes in microbial structure, which may alter host response. We conducted a randomized, double-blind, placebo-controlled crossover trial in ten healthy adults to evaluate the effects of a common dose of G&C compared to placebo for 14 days on gut microbial community structure, measured by 16S rRNA gene sequencing. Linear mixed models were used to evaluate the effect of G&C compared to placebo on fecal microbial alpha and beta diversity, seven phyla, and 137 genera. Nine genera were significantly different between interventions (False Discovery Rate < 0.05). Abundances of four Lachnospiraceae genera, two Prevotellaceae genera, and Desulfovibrio were increased after G&C compared to placebo, while Bifidobacterium and a member of the Christensenellaceae family were decreased. Our results suggest that G&C affect the composition of the gut microbiome which may have implications for therapeutic efficacy.

show abstract

Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 62%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Modulation of Gut Microbiota by Glucosamine and Chondroitin in a Randomized, Double-Blind Pilot Trial in Humans

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Bacteroides, Bidobacterium and Clostridium mainly helped to ferment FCS-pg, which increased the content of probiotic bacteria; this is slightly different from most sulfated polysaccharides procured from marine animals. The study also provided useful information about the mechanism of absorption and the functional activity of FCS-pg within the gastrointestinal tract of the human body 45. 3.31 Novel biological roles of fucosylated chondroitin sulfates isolated from the sea cucumber Apostichopus japonicus exhibit neurite outgrowth promoting activityFig.…”

mentioning

confidence: 99%

Chondroitin: a natural biomarker with immense biomedical applications

Pal

Saha²

2019

RSC Adv.

View full text Add to dashboard Cite

show abstract

The interaction between dietary marine components and intestinal flora

Lin

Xue

Zhang

et al. 2020

Mar Life Sci Technol

View full text Add to dashboard Cite

The intestine is the natural habitat for a large and dynamic bacterial community, which perform vital metabolic and immune functions that significantly effect the nutritional and health status of the host. The major physiological functions of intestinal flora include metabolic activities that lead to important trophic effects on immune structure and function as well as protection of the colonized host against invasion by transient microbes. The intestinal flora is both a target for nutritional intervention and a factor influencing the biological activity of food compounds acquired orally. Marine environments, as a source of diverse organic compounds, can supply us with a number of beneficial and health-promoting ingredients. This review focuses on the physiological functions of intestinal flora and reciprocal interactions between intestinal flora and dietary marine components including polysaccharides, lipids, protein, taurine, carotenoids, minerals, and polyphenols. This review can serve as a valuable reference regarding the consumption of seafood and marine nutraceuticals.

show abstract

In vitro fermentation behaviors of fucosylated chondroitin sulfate from Pearsonothuria graeffei by human gut microflora

Cited by 25 publications

References 47 publications

Modulation of Gut Microbiota by Glucosamine and Chondroitin in a Randomized, Double-Blind Pilot Trial in Humans

Modulation of Gut Microbiota by Glucosamine and Chondroitin in a Randomized, Double-Blind Pilot Trial in Humans

Chondroitin: a natural biomarker with immense biomedical applications

The interaction between dietary marine components and intestinal flora

Contact Info

Product

Resources

About