in vitro experiments and in vivo implants to evaluate a new silicone-based polyurethane material for replacement of small vessels

Abstract

the idea underscoring our proposed development is to take advantage of the good properties of both polyurethanes (pu) and silicones (pdms). the attributes which make polyurethanes attractive as materials for biomedical applications are their excellent physical–chemical properties, and their relatively good biocompatibility. against their use is the phenomenon of biodegradation that occurs after long-term implantation. silicones, on the other end, are known to have long-term biostability and good haemocompatibility subsequent to their use in several biomedical settings.

A Combined Synthetic-Fibrin Scaffold Supports Growth and Cardiomyogenic Commitment of Human Placental Derived Stem Cells

“…The first approach for the selection of a suitable scaffold for tissue engineering should be the evaluation of its in vitro cell culture biocompatibility as well as its cytotoxicity [20], [21], [53], [54]. We found no evidence of cellular toxicity, but on the contrary the results of our study confirmed the biocompatibility and cell-friendly property of this scaffold.…”

“…Afterwards, the thrombin incorporated in the deposited material reacts with fibrinogen to form a nanostructured fibrin layer firmly attached on the top of the synthetic layer, as previously demonstrated by peel-out test [22]. The s-IPN PEtU-PDMS/fibrin combined scaffold can be tailored with elastic modulus and mechanical strength matching approximately those of the human myocardium at the end of diastole [22]; it is biocompatible and evokes a limited inflammatory response, as already demonstrated by in vitro and in vivo experiments [21], [22], [53], [54].…”

Biomimetic Materials and Scaffolds for Myocardial Tissue Regeneration

“…Lisi et al produced composite scaffolds based on a poly(ether)urethane‐polydimethylsiloxane and fibrin (PEtU‐PDMS/fibrin) by simultaneous deposition of the synthetic component and a thrombin solution on a rotating mandrel, followed by thrombin reaction with fibrinogen to form a thin, nanostructured fibrin layer, composed of randomly oriented fibers firmly attached to the synthetic layer below. On the base of previous studies demonstrating the biocompatibility of this substrate, Lisi at al. used it to develop a potential construct to be applied as a delivery system of stem cells to the infarcted regions of the heart, able to support cell proliferation and differentiation and showing suitable mechanical properties and handiness to withstand the continuous contraction/relaxation of cardiac tissue.…”

Effect of intraluminal pillars on particle motion in bifurcated microchannels

“…It should be noted, however, that there are many approaches to modifying the PDMS for use in biological applications (Fuji 2002; Shevkoplyas et al 2005; Simpson et al 1998; Soldani et al 2004; Squires and Quake 2005; Stone et al 2004). Finally, the photolithography technique produces random irregularities (rugosities) that must be a considered in developing appropriate sampling techniques and rigorous experimental design (Fuji 2002; Roberts et al 1997).…”